ES321651A1 - A procedure for the purification of preparation of precious gonadotropin by precipitation with an alcohol in acid medium. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the purification of preparation of precious gonadotropin by precipitation with an alcohol in acid medium. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES321651A1
ES321651A1 ES0321651A ES321651A ES321651A1 ES 321651 A1 ES321651 A1 ES 321651A1 ES 0321651 A ES0321651 A ES 0321651A ES 321651 A ES321651 A ES 321651A ES 321651 A1 ES321651 A1 ES 321651A1
Authority
ES
Spain
Prior art keywords
alcohol
gonadotropin
precipitation
preparation
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0321651A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Organon NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NL6500350A external-priority patent/NL6500350A/xx
Application filed by Organon NV filed Critical Organon NV
Publication of ES321651A1 publication Critical patent/ES321651A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process for the purification of a crude gonadotropin preparation by precipitation with an alcohol in an acid medium, comprising the steps of creating a clear solution of the preparation containing a molar fraction of an alcohol of at least 0.33, having a pH between approximately 6 and 9, and containing at least one salt soluble in mixtures of water and alcohol with a molar fraction of 0.016 maximum and a molar fraction of water between about 0.50 and 0.65, add to this at least an acid until the measured pH has reached a value between about 3 and 6, and simultaneously raise the alcohol concentration for the selective precipitation of the gonadotropin. (Machine-translation by Google Translate, not legally binding)
ES0321651A 1965-01-13 1966-01-12 A procedure for the purification of preparation of precious gonadotropin by precipitation with an alcohol in acid medium. (Machine-translation by Google Translate, not legally binding) Expired ES321651A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL6500350A NL6500350A (en) 1965-01-13 1965-01-13

Publications (1)

Publication Number Publication Date
ES321651A1 true ES321651A1 (en) 1966-10-01

Family

ID=19792096

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0321651A Expired ES321651A1 (en) 1965-01-13 1966-01-12 A procedure for the purification of preparation of precious gonadotropin by precipitation with an alcohol in acid medium. (Machine-translation by Google Translate, not legally binding)

Country Status (3)

Country Link
DK (1) DK115488B (en)
ES (1) ES321651A1 (en)
SE (1) SE321308B (en)

Also Published As

Publication number Publication date
SE321308B (en) 1970-03-02
DK115488B (en) 1969-10-13

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