ES316390A1 - Procedimiento para la obtencion de péptidos con efecto acth - Google Patents
Procedimiento para la obtencion de péptidos con efecto acthInfo
- Publication number
- ES316390A1 ES316390A1 ES0316390A ES316390A ES316390A1 ES 316390 A1 ES316390 A1 ES 316390A1 ES 0316390 A ES0316390 A ES 0316390A ES 316390 A ES316390 A ES 316390A ES 316390 A1 ES316390 A1 ES 316390A1
- Authority
- ES
- Spain
- Prior art keywords
- boc
- lys
- pro
- val
- otbu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 239000000275 Adrenocorticotropic Hormone Substances 0.000 title abstract 2
- 101800000414 Corticotropin Proteins 0.000 title abstract 2
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 title abstract 2
- 229960000258 corticotropin Drugs 0.000 title abstract 2
- 102400000739 Corticotropin Human genes 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 108010015792 glycyllysine Proteins 0.000 abstract 22
- 108010071207 serylmethionine Proteins 0.000 abstract 9
- 108010053725 prolylvaline Proteins 0.000 abstract 5
- 125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 3
- 125000000539 amino acid group Chemical group 0.000 abstract 3
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 3
- VVQIIIAZJXTLRE-QMMMGPOBSA-N (2s)-2-amino-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid Chemical compound CC(C)(C)OC(=O)NCCCC[C@H](N)C(O)=O VVQIIIAZJXTLRE-QMMMGPOBSA-N 0.000 abstract 2
- 108010060035 arginylproline Proteins 0.000 abstract 2
- LHHCSNFAOIFYRV-DOVBMPENSA-N boceprevir Chemical class O=C([C@@H]1[C@@H]2[C@@H](C2(C)C)CN1C(=O)[C@@H](NC(=O)NC(C)(C)C)C(C)(C)C)NC(C(=O)C(N)=O)CC1CCC1 LHHCSNFAOIFYRV-DOVBMPENSA-N 0.000 abstract 2
- FHOAKXBXYSJBGX-RXMQYKEDSA-N (2r)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Chemical compound CC(C)(C)OC(=O)N[C@H](CO)C(O)=O FHOAKXBXYSJBGX-RXMQYKEDSA-N 0.000 abstract 1
- CNBUSIJNWNXLQQ-NSHDSACASA-N (2s)-3-(4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Chemical compound CC(C)(C)OC(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 CNBUSIJNWNXLQQ-NSHDSACASA-N 0.000 abstract 1
- RWQCKACYKKSOKK-AWEZNQCLSA-N (2s)-5-[(2-methylpropan-2-yl)oxycarbonylamino]-2-(phenylmethoxycarbonylamino)pentanoic acid Chemical compound CC(C)(C)OC(=O)NCCC[C@@H](C(O)=O)NC(=O)OCC1=CC=CC=C1 RWQCKACYKKSOKK-AWEZNQCLSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 108010068380 arginylarginine Proteins 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 108010017391 lysylvaline Proteins 0.000 abstract 1
- 108010056582 methionylglutamic acid Proteins 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- -1 p-nitrophenyl ester Chemical class 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 108010090894 prolylleucine Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 108010020532 tyrosyl-proline Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/695—Corticotropin [ACTH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Feeding And Watering For Cattle Raising And Animal Husbandry (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1058364A CH499497A (de) | 1964-08-13 | 1964-08-13 | Verfahren zur Herstellung neuer Polypeptide |
| CH1550964 | 1964-12-02 | ||
| CH303765A CH548986A (de) | 1964-08-13 | 1965-03-04 | Verfahren zur herstellung neuer peptide mit acth-wirkung. |
| CH831665 | 1965-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES316390A1 true ES316390A1 (es) | 1966-04-01 |
Family
ID=27428551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0316390A Expired ES316390A1 (es) | 1964-08-13 | 1965-08-11 | Procedimiento para la obtencion de péptidos con efecto acth |
Country Status (12)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3503951A (en) * | 1965-06-15 | 1970-03-31 | Ciba Geigy Corp | Complexes of a.c.t.h. peptides with polyglutamic and polyaspartic acid |
| BE758206A (fr) * | 1969-10-31 | 1971-04-29 | Hoechst Ag | Peptides a activite adrenocorticotrope et medicaments qui en contiennent |
| US4130514A (en) * | 1978-02-10 | 1978-12-19 | Armour Pharmaceutical Company | Synthesis of peptides |
| CN117106057B (zh) * | 2022-08-19 | 2024-11-01 | 南京汉欣医药科技有限公司 | 一种高纯的人促肾上腺皮质激素或其类似物及其规模化制备方法 |
-
0
- BE BE668249D patent/BE668249A/xx unknown
- BE BE668250D patent/BE668250A/xx unknown
-
1964
- 1964-08-13 CH CH1058364A patent/CH499497A/de not_active IP Right Cessation
-
1965
- 1965-03-04 CH CH303765A patent/CH548986A/xx not_active IP Right Cessation
- 1965-08-06 GB GB3384665A patent/GB1119353A/en not_active Expired
- 1965-08-11 ES ES0316390A patent/ES316390A1/es not_active Expired
- 1965-08-12 NO NO15932765A patent/NO124831B/no unknown
- 1965-08-12 CS CS502165A patent/CS150525B2/cs unknown
- 1965-08-12 NL NL6510560A patent/NL6510560A/xx unknown
- 1965-08-12 AT AT745665A patent/AT295050B/de not_active IP Right Cessation
- 1965-08-12 SE SE1056865A patent/SE348464B/xx unknown
- 1965-08-12 NL NL6510562A patent/NL6510562A/xx unknown
- 1965-08-13 BR BR17212265A patent/BR6572122D0/pt unknown
- 1965-11-10 FR FR37967A patent/FR4902M/fr not_active Expired
- 1965-11-10 FR FR37968A patent/FR5091M/fr not_active Expired
- 1965-11-10 FR FR37965A patent/FR4900M/fr not_active Expired
- 1965-11-10 FR FR37966A patent/FR4901M/fr not_active Expired
-
1969
- 1969-12-31 MY MY6900354A patent/MY6900354A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE1493559B2 (de) | 1976-01-15 |
| DE1493559A1 (de) | 1970-10-29 |
| NL6510562A (enrdf_load_stackoverflow) | 1966-02-14 |
| CH499497A (de) | 1970-11-30 |
| AT295050B (de) | 1971-12-27 |
| BR6572122D0 (pt) | 1973-08-02 |
| CS150525B2 (enrdf_load_stackoverflow) | 1973-09-04 |
| FR4902M (enrdf_load_stackoverflow) | 1967-03-13 |
| MY6900354A (en) | 1969-12-31 |
| SE348464B (enrdf_load_stackoverflow) | 1972-09-04 |
| GB1119353A (en) | 1968-07-10 |
| CH548986A (de) | 1974-05-15 |
| BE668249A (enrdf_load_stackoverflow) | |
| FR4901M (enrdf_load_stackoverflow) | 1967-03-13 |
| FR4900M (enrdf_load_stackoverflow) | 1967-03-13 |
| NO124831B (enrdf_load_stackoverflow) | 1972-06-12 |
| FR5091M (enrdf_load_stackoverflow) | 1967-05-22 |
| NL6510560A (enrdf_load_stackoverflow) | 1966-02-14 |
| BE668250A (enrdf_load_stackoverflow) |
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