ES315655A1 - Procedure for the preparation of a new derivative of isoxazol. (Machine-translation by Google Translate, not legally binding)
- Google Patents
Procedure for the preparation of a new derivative of isoxazol. (Machine-translation by Google Translate, not legally binding)
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Novartis AG
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Ciba Geigy AG
JR Geigy AG
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Priority claimed from CH530965Aexternal-prioritypatent/CH454147A/en
Application filed by Ciba Geigy AG, JR Geigy AGfiledCriticalCiba Geigy AG
Publication of ES315655A1publicationCriticalpatent/ES315655A1/en
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms
(AREA)
Abstract
Process for the preparation of a new isoxazole derivative of the formula I ** (See formula) ** and its salts, which is characterized by reacting a reactive ester of 5- (hydroxymethyl) -3-isoxazolol of the formula II ** (See formula) ** with respect to its alpha-hydroxyl group, with a salt of hydrocyanic acid, to form the 3-hydroxy-5-isoxazolacetonitrile of the formula III ** (See formula) ** by acting bromine on this, by reacting with ammonia the product of bromination, of formula IV ** (See formula) ** by transforming, if desired, the obtained alpha-amino-3-hydroxy-5-isoxazolacetonitrile, of the formula V ** (See formula) ** by reaction with hydrogen halide and a lower alkanol and optionally consecutive treatment with water, in the corresponding lower alkyl amino ester or respectively the corresponding lower alkyl ester and by hydrolyzing the obtained nitrile or the obtained imino ester or ester, in order to obtain the acid free. (Machine-translation by Google Translate, not legally binding)
ES0315655A1964-07-221965-07-05Procedure for the preparation of a new derivative of isoxazol. (Machine-translation by Google Translate, not legally binding)
ExpiredES315655A1
(en)