ES3064045T3 - Compounds for treating lymphoma or a t-cell malignant disease - Google Patents
Compounds for treating lymphoma or a t-cell malignant diseaseInfo
- Publication number
- ES3064045T3 ES3064045T3 ES19835807T ES19835807T ES3064045T3 ES 3064045 T3 ES3064045 T3 ES 3064045T3 ES 19835807 T ES19835807 T ES 19835807T ES 19835807 T ES19835807 T ES 19835807T ES 3064045 T3 ES3064045 T3 ES 3064045T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- malignant disease
- cell malignant
- treating lymphoma
- tinostamustine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Primary Health Care (AREA)
- Medical Informatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a la tinostamustina para el tratamiento del linfoma o de una enfermedad maligna de células T. La tinostamustina puede causar efectos secundarios al administrarse a un paciente, por lo que es deseable minimizarlos. La presente invención define un tratamiento mejorado, en el que la dosis de tinostamustina administrada se ajusta según el recuento de plaquetas del paciente. (Traducción automática con Google Translate, sin valor legal)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1820643.3A GB201820643D0 (en) | 2018-12-18 | 2018-12-18 | Compounds for treating multiple myeloma |
| GBGB1820645.8A GB201820645D0 (en) | 2018-12-18 | 2018-12-18 | Compounds for treating lymphoma or a T-cell malignant disease |
| GBGB1903005.5A GB201903005D0 (en) | 2019-03-06 | 2019-03-06 | Compounds for treating multiple myeloma |
| GBGB1903003.0A GB201903003D0 (en) | 2019-03-06 | 2019-03-06 | Compounds for treating lymphoma or a T-cell malignant disease |
| GBGB1908434.2A GB201908434D0 (en) | 2019-06-12 | 2019-06-12 | Compounds for treating lymphoma or a t-cell malignant disease |
| GBGB1908436.7A GB201908436D0 (en) | 2019-06-12 | 2019-06-12 | Compounds for treating multiple myeloma |
| PCT/IB2019/061034 WO2020128912A1 (en) | 2018-12-18 | 2019-12-18 | Compounds for treating lymphoma or a t-cell malignant disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES3064045T3 true ES3064045T3 (en) | 2026-04-22 |
Family
ID=69159864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES19835807T Active ES3064045T3 (en) | 2018-12-18 | 2019-12-18 | Compounds for treating lymphoma or a t-cell malignant disease |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12377076B2 (es) |
| EP (2) | EP3897625B1 (es) |
| JP (2) | JP2022514048A (es) |
| KR (1) | KR20210105380A (es) |
| CN (2) | CN113365624A (es) |
| AU (2) | AU2019400983B2 (es) |
| CA (2) | CA3124005A1 (es) |
| ES (1) | ES3064045T3 (es) |
| WO (2) | WO2020128913A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201409471D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409485D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| AU2016426574B2 (en) | 2016-10-11 | 2023-07-13 | Euro-Celtique S.A. | Hodgkin lymphoma therapy |
| GB201709402D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating t-pll |
| GB201709403D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating sarcoma |
| GB201709406D0 (en) | 2017-06-13 | 2017-07-26 | Euro-Cletique S A | Compounds for treating TNBC |
| GB201709405D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating ovarian cancer |
| WO2020128913A1 (en) | 2018-12-18 | 2020-06-25 | Mundipharma International Corporation Limited | Compounds for treating multiple myeloma |
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|---|---|---|---|---|
| DE34727C (de) | Ch. H. TH. HAVEMANN in Paris, 16 rue Bleue | Verfahren zur direkten Gewinnung metallischen Bleis | ||
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US6407079B1 (en) | 1985-07-03 | 2002-06-18 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation |
| GB8926612D0 (en) | 1989-11-24 | 1990-01-17 | Erba Farmitalia | Pharmaceutical compositions |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| US5369108A (en) | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| GB9126209D0 (en) | 1991-12-10 | 1992-02-12 | Orion Yhtymae Oy | Drug formulations for parenteral use |
| US5602112A (en) | 1992-06-19 | 1997-02-11 | Supergen, Inc. | Pharmaceutical formulation |
| US5882941A (en) | 1994-05-04 | 1999-03-16 | Massachusette Institute Of Technology | Programmable genotoxic agents and uses therefor |
| US6046177A (en) | 1997-05-05 | 2000-04-04 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations |
| US5874418A (en) | 1997-05-05 | 1999-02-23 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use |
| WO1998056422A1 (en) | 1997-06-13 | 1998-12-17 | The University Of Kansas | Polar drug or prodrug compositions with extended shelf-life storage and a method of making thereof |
| US6040321A (en) | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
| US6214852B1 (en) | 1998-10-21 | 2001-04-10 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
| US6392053B2 (en) | 1999-12-15 | 2002-05-21 | Bristol-Myers Squibb Company | Process for preparing arylacetylaminothiazoles |
| US20020076409A1 (en) | 2000-07-12 | 2002-06-20 | March Carl J. | Method for treating cancer |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| WO2002026696A1 (en) | 2000-09-29 | 2002-04-04 | Prolifix Limited | Carbamic acid compounds comprising an amide linkage as hdac inhibitors |
| AU2002243231A1 (en) | 2000-11-21 | 2002-07-24 | Wake Forest University | Method of treating autoimmune diseases |
| CN1764648A (zh) | 2003-01-13 | 2006-04-26 | 安斯泰来制药有限公司 | 作为组蛋白脱乙酰酶(hdac)抑制剂的异羟肟酸衍生物 |
| WO2004076386A2 (en) | 2003-02-25 | 2004-09-10 | Topotarget Uk Limited | Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors |
| US20060270730A1 (en) | 2003-08-07 | 2006-11-30 | Andreas Katopodis | Histone deacetylase inhibitors as immunosuppressants |
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| CN102579417B (zh) | 2005-05-13 | 2014-11-26 | 托波塔吉特英国有限公司 | Hdac抑制剂的药物制剂 |
| UA95310C2 (ru) | 2006-10-20 | 2011-07-25 | Айкос Корпорейшен | Композиция, содержащая ингибитор chk1 и циклодекстрин, для лечения рака |
| GB0621160D0 (en) | 2006-10-24 | 2006-12-06 | Imp College Innovations Ltd | Compounds and uses thereof |
| DE602007009717D1 (de) | 2006-11-20 | 2010-11-18 | Cephalon Inc | Verfahren zur strahlensensibilisierung von tumoren mit einem strahlensensibilisierungsmittel |
| CN101084876A (zh) | 2007-07-11 | 2007-12-12 | 济南康泉医药科技有限公司 | 一种含苯达莫司汀的抗癌组合物 |
| TW200922564A (en) | 2007-09-10 | 2009-06-01 | Curis Inc | CDK inhibitors containing a zinc binding moiety |
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| EP2346836B1 (en) | 2008-10-08 | 2018-03-07 | Cephalon, Inc. | Processes for the preparation of bendamustine |
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| CA2753641C (en) | 2009-02-25 | 2014-09-16 | Supratek Pharma, Inc. | Bendamustine cyclopolysaccharide compositions |
| US8603521B2 (en) | 2009-04-17 | 2013-12-10 | Pharmacyclics, Inc. | Formulations of histone deacetylase inhibitor and uses thereof |
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| US9889147B2 (en) | 2010-04-16 | 2018-02-13 | Cellact Pharma Gmbh | Analogues of etoposide for the treatment of tumours |
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| US8748470B2 (en) | 2011-03-17 | 2014-06-10 | The University Of Chicago | Methods for treating ovarian cancer by inhibiting fatty acid binding proteins |
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| GB201409485D0 (en) * | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409471D0 (en) * | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409488D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| US9937174B2 (en) | 2014-12-05 | 2018-04-10 | University of Modena and Reggio Emilia | Combinations of histone deacetylase inhibitors and bendamustine |
| US20180028497A1 (en) * | 2015-02-19 | 2018-02-01 | Novartis Ag | Panobinostat dosages for multiple myeloma |
| WO2017067474A1 (zh) | 2015-10-20 | 2017-04-27 | 杭州民生药物研究院有限公司 | 一种药物组合物及其制备方法 |
| AU2016426574B2 (en) | 2016-10-11 | 2023-07-13 | Euro-Celtique S.A. | Hodgkin lymphoma therapy |
| US20180098969A1 (en) | 2016-10-11 | 2018-04-12 | Purdue Pharmaceutical Products L.P. | Hodgkin lymphoma therapy |
| GB201709403D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating sarcoma |
| GB201709406D0 (en) | 2017-06-13 | 2017-07-26 | Euro-Cletique S A | Compounds for treating TNBC |
| GB201709402D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating t-pll |
| GB201709405D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating ovarian cancer |
| WO2020128913A1 (en) | 2018-12-18 | 2020-06-25 | Mundipharma International Corporation Limited | Compounds for treating multiple myeloma |
| US20240252472A1 (en) | 2023-01-25 | 2024-08-01 | Purdue Pharma L.P. | Combinations for treating cancer |
-
2019
- 2019-12-18 WO PCT/IB2019/061035 patent/WO2020128913A1/en not_active Ceased
- 2019-12-18 ES ES19835807T patent/ES3064045T3/es active Active
- 2019-12-18 WO PCT/IB2019/061034 patent/WO2020128912A1/en not_active Ceased
- 2019-12-18 EP EP19835807.9A patent/EP3897625B1/en active Active
- 2019-12-18 CN CN201980084596.9A patent/CN113365624A/zh active Pending
- 2019-12-18 AU AU2019400983A patent/AU2019400983B2/en active Active
- 2019-12-18 CA CA3124005A patent/CA3124005A1/en active Pending
- 2019-12-18 JP JP2021535301A patent/JP2022514048A/ja active Pending
- 2019-12-18 CN CN201980084762.5A patent/CN113365625A/zh active Pending
- 2019-12-18 KR KR1020217021704A patent/KR20210105380A/ko not_active Ceased
- 2019-12-18 AU AU2019402158A patent/AU2019402158B2/en active Active
- 2019-12-18 EP EP19835808.7A patent/EP3897626B1/en active Active
- 2019-12-18 CA CA3124001A patent/CA3124001A1/en active Pending
- 2019-12-18 US US17/414,797 patent/US12377076B2/en active Active
- 2019-12-18 US US17/414,806 patent/US20220016085A1/en active Pending
- 2019-12-18 JP JP2021535307A patent/JP2022522928A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019400983B2 (en) | 2025-07-03 |
| AU2019400983A1 (en) | 2021-06-10 |
| WO2020128912A1 (en) | 2020-06-25 |
| AU2019402158A1 (en) | 2021-06-10 |
| WO2020128913A1 (en) | 2020-06-25 |
| CN113365625A (zh) | 2021-09-07 |
| EP3897626A1 (en) | 2021-10-27 |
| EP3897625B1 (en) | 2026-01-28 |
| US12377076B2 (en) | 2025-08-05 |
| EP3897625C0 (en) | 2026-01-28 |
| EP3897626B1 (en) | 2025-09-10 |
| US20220016084A1 (en) | 2022-01-20 |
| CA3124005A1 (en) | 2020-06-25 |
| AU2019402158B2 (en) | 2025-07-03 |
| US20220016085A1 (en) | 2022-01-20 |
| JP2022514048A (ja) | 2022-02-09 |
| EP3897626C0 (en) | 2025-09-10 |
| EP3897625A1 (en) | 2021-10-27 |
| CN113365624A (zh) | 2021-09-07 |
| JP2022522928A (ja) | 2022-04-21 |
| CA3124001A1 (en) | 2020-06-25 |
| KR20210105380A (ko) | 2021-08-26 |
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