ES305791A1 - Procedure for the preparation of sulfur piridine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of sulfur piridine derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES305791A1
ES305791A1 ES0305791A ES305791A ES305791A1 ES 305791 A1 ES305791 A1 ES 305791A1 ES 0305791 A ES0305791 A ES 0305791A ES 305791 A ES305791 A ES 305791A ES 305791 A1 ES305791 A1 ES 305791A1
Authority
ES
Spain
Prior art keywords
formula
acid addition
compound
salt
meaning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0305791A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck KGaA
Original Assignee
E Merck AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E Merck AG filed Critical E Merck AG
Publication of ES305791A1 publication Critical patent/ES305791A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Process for the preparation of sulfuric derivatives of pyridine, of the formula I ** (See formula) ** where R1 and R2 mean hydrogen or acyl, and R3 means an optionally substituted alkyl radical, an alkenyl or alkynyl radical or an optionally substituted aryl or aralkyl radical, and their acid addition salts, characterized by: a) reacting a 3-mercaptomethyl-pyridine derivative of the formula II ** (See formula) ** where R1 and R2 have the meaning stated above, and R4 means hydrogen, ammonium or an equivalent of a metal atom, preferably sodium, or a salt thereof of acid addition, with a sulfurous compound of formula III ** (See formula) ** where Y means -SO3R4, -S02R3, -SOR3, bromine, chlorine or -S-CM and R3, and R4 have the meaning stated above, or b) Reacting a sulphurous pyridine derivative of the formula IV ** (See formula) ** where Z means -SO3R4, chloro or bromo and * R1, R2 and R4 have the meaning already stated, or a salt thereof of acid addition, with a mercaptanic derivative of the formula ** (See formula) ** wherein R3 and R4 have the meaning set forth above, and, optionally, treat a compound of the formula I wherein R1 and/or R2 mean hydrogen with an addictive agent, or a compound of the formula I in which R1 and/or R2 they mean an acyl radical with a saponification agent; as well as optionally converting a compound of the formula I into an acid addition salt thereof or, from an acid addition salt of the formula I, in the already ordinary manner, releasing the base. (Machine-translation by Google Translate, not legally binding)
ES0305791A 1963-11-09 1964-11-07 Procedure for the preparation of sulfur piridine derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES305791A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEM0058865 1963-11-09

Publications (1)

Publication Number Publication Date
ES305791A1 true ES305791A1 (en) 1965-04-16

Family

ID=7309364

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0305791A Expired ES305791A1 (en) 1963-11-09 1964-11-07 Procedure for the preparation of sulfur piridine derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (12)

Country Link
US (1) US3324140A (en)
BE (1) BE655454A (en)
BR (1) BR6464084D0 (en)
CH (1) CH463502A (en)
DE (1) DE1470054A1 (en)
DK (1) DK111750B (en)
ES (1) ES305791A1 (en)
FR (1) FR4036M (en)
GB (1) GB1032377A (en)
IL (1) IL22280A (en)
NL (1) NL146159B (en)
SE (1) SE315894B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5137877B1 (en) * 1990-05-14 1996-01-30 Bristol Myers Squibb Co Bifunctional linking compounds conjugates and methods for their production
US7282590B2 (en) * 2004-02-12 2007-10-16 The Research Foundation Of State University Of New York Drug conjugates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1915334A (en) * 1930-10-16 1933-06-27 Du Pont Fluosilicate of organic heterocyclic bases and process of making it
US2075359A (en) * 1930-10-16 1937-03-30 Du Pont Insecticide
BE633927A (en) * 1958-03-21
US3039930A (en) * 1960-04-06 1962-06-19 Irwin Neisler And Co Pyridyl carbamyl lower alkane derivatives: analgesic process

Also Published As

Publication number Publication date
SE315894B (en) 1969-10-13
DE1470054A1 (en) 1969-05-29
BR6464084D0 (en) 1973-07-26
GB1032377A (en) 1966-06-08
US3324140A (en) 1967-06-06
IL22280A (en) 1968-12-26
BE655454A (en) 1965-05-10
DK111750B (en) 1968-10-07
NL146159B (en) 1975-06-16
FR4036M (en) 1966-03-28
NL6412891A (en) 1965-05-10
CH463502A (en) 1968-10-15

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