ES2992031T3 - Péptidos de arginasa inmunógenos - Google Patents
Péptidos de arginasa inmunógenos Download PDFInfo
- Publication number
- ES2992031T3 ES2992031T3 ES17786870T ES17786870T ES2992031T3 ES 2992031 T3 ES2992031 T3 ES 2992031T3 ES 17786870 T ES17786870 T ES 17786870T ES 17786870 T ES17786870 T ES 17786870T ES 2992031 T3 ES2992031 T3 ES 2992031T3
- Authority
- ES
- Spain
- Prior art keywords
- arginase
- seq
- peptide
- cells
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 247
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 124
- 108700024123 Arginases Proteins 0.000 title claims abstract description 106
- 102000004452 Arginase Human genes 0.000 title claims abstract description 105
- 230000002163 immunogen Effects 0.000 title claims abstract description 36
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 80
- 201000011510 cancer Diseases 0.000 claims abstract description 59
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- 239000012634 fragment Substances 0.000 claims abstract description 38
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- 235000001014 amino acid Nutrition 0.000 claims description 83
- 150000001413 amino acids Chemical class 0.000 claims description 76
- 101710129000 Arginase-1 Proteins 0.000 claims description 74
- 102100021723 Arginase-1 Human genes 0.000 claims description 74
- 239000000203 mixture Substances 0.000 claims description 54
- 239000002671 adjuvant Substances 0.000 claims description 51
- 238000000034 method Methods 0.000 claims description 48
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- 150000007523 nucleic acids Chemical class 0.000 claims description 42
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 23
- 210000004443 dendritic cell Anatomy 0.000 claims description 20
- 201000010099 disease Diseases 0.000 claims description 17
- 238000002560 therapeutic procedure Methods 0.000 claims description 15
- 230000000118 anti-neoplastic effect Effects 0.000 claims description 14
- 102100030356 Arginase-2, mitochondrial Human genes 0.000 claims description 11
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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Landscapes
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16192794 | 2016-10-07 | ||
| PCT/EP2017/075443 WO2018065563A1 (en) | 2016-10-07 | 2017-10-06 | Immunogenic arginase peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2992031T3 true ES2992031T3 (es) | 2024-12-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17786870T Active ES2992031T3 (es) | 2016-10-07 | 2017-10-06 | Péptidos de arginasa inmunógenos |
Country Status (18)
| Country | Link |
|---|---|
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| PL3522905T3 (pl) | 2016-10-07 | 2025-01-07 | Io Biotech Aps | Immunogenne peptydy arginazowe |
| GB201815549D0 (en) * | 2018-09-24 | 2018-11-07 | Io Biotech Aps | Arginase1 polypeptides |
| GB201818576D0 (en) * | 2018-11-14 | 2018-12-26 | Io Biotech Aps | Arginase 2 polypeptides |
| GB201912030D0 (en) * | 2019-08-21 | 2019-10-02 | Cancer Research Tech Ltd | Binding molecules |
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| US20250161422A1 (en) | 2022-02-24 | 2025-05-22 | Io Biotech Aps | Arginase 2 vaccine |
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| US58767A (en) | 1866-10-16 | John brougjbton | ||
| US5554372A (en) | 1986-09-22 | 1996-09-10 | Emory University | Methods and vaccines comprising surface-active copolymers |
| US5780286A (en) * | 1996-03-14 | 1998-07-14 | Smithkline Beecham Corporation | Arginase II |
| US20110111424A1 (en) | 2001-06-21 | 2011-05-12 | Cell Signaling Technology, Inc. | Analysis of ubiquitinated polypeptides |
| WO2003038444A2 (en) | 2001-10-31 | 2003-05-08 | Pfizer Products Inc. | Biomarkers of liver function |
| CA2836155A1 (en) | 2004-10-29 | 2006-05-11 | Board Of Trustees Of Michigan State University | Protection against herbivores |
| PL3064579T3 (pl) | 2008-10-31 | 2021-07-05 | Aerase, Inc. | Kompozycje farmaceutyczne i zastosowania medyczne uzyskanych metodami inżynierii ludzkich arginaz |
| CA2766039A1 (en) * | 2009-06-29 | 2011-01-20 | The Board Of Regents Of The University Of Texas System | Arginase formulations and methods |
| EP3137103B1 (en) | 2014-04-29 | 2021-10-20 | Bio-Cancer Treatment International Ltd. | Methods and compositions for modulating the immune system with arginase i |
| GB201501017D0 (en) * | 2014-12-23 | 2015-03-04 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
| PL3522905T3 (pl) * | 2016-10-07 | 2025-01-07 | Io Biotech Aps | Immunogenne peptydy arginazowe |
| CN109890838A (zh) * | 2016-10-27 | 2019-06-14 | Io生物技术公司 | 新的pdl2化合物 |
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| JP2019537562A (ja) | 2019-12-26 |
| MX2019003970A (es) | 2019-12-05 |
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| SI3522905T1 (sl) | 2025-02-28 |
| PL3522905T3 (pl) | 2025-01-07 |
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| EP3522905B1 (en) | 2024-09-25 |
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| EP3522905A1 (en) | 2019-08-14 |
| EP4406613A2 (en) | 2024-07-31 |
| US20190338270A1 (en) | 2019-11-07 |
| US20240167013A1 (en) | 2024-05-23 |
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| LT3522905T (lt) | 2024-11-11 |
| IL265805A (en) | 2019-06-30 |
| US10858642B2 (en) | 2020-12-08 |
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