ES2978375T3 - Métodos, composiciones y kits para el análisis de lípidos complejos estructuralmente diversos - Google Patents

Métodos, composiciones y kits para el análisis de lípidos complejos estructuralmente diversos Download PDF

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Publication number
ES2978375T3
ES2978375T3 ES15827995T ES15827995T ES2978375T3 ES 2978375 T3 ES2978375 T3 ES 2978375T3 ES 15827995 T ES15827995 T ES 15827995T ES 15827995 T ES15827995 T ES 15827995T ES 2978375 T3 ES2978375 T3 ES 2978375T3
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ES
Spain
Prior art keywords
lipid
mixture
fatty acids
sample
fatty acid
Prior art date
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Active
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ES15827995T
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English (en)
Spanish (es)
Inventor
Steven Watkins
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Metabolon Inc
Original Assignee
Metabolon Inc
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Filing date
Publication date
Application filed by Metabolon Inc filed Critical Metabolon Inc
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Publication of ES2978375T3 publication Critical patent/ES2978375T3/es
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N2030/042—Standards
    • G01N2030/045—Standards internal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2496/00—Reference solutions for assays of biological material
    • G01N2496/80—Multi-analyte reference solutions containing cholesterol, glucose and the like
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104165—Lipid, cholesterol, or triglyceride standard or control

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ES15827995T 2014-07-30 2015-07-30 Métodos, composiciones y kits para el análisis de lípidos complejos estructuralmente diversos Active ES2978375T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462031099P 2014-07-30 2014-07-30
PCT/US2015/042904 WO2016019140A1 (en) 2014-07-30 2015-07-30 Methods, compositions, and kits for analysis of structurally diverse complex lipids

Publications (1)

Publication Number Publication Date
ES2978375T3 true ES2978375T3 (es) 2024-09-11

Family

ID=55218314

Family Applications (1)

Application Number Title Priority Date Filing Date
ES15827995T Active ES2978375T3 (es) 2014-07-30 2015-07-30 Métodos, composiciones y kits para el análisis de lípidos complejos estructuralmente diversos

Country Status (8)

Country Link
US (1) US11181535B2 (https=)
EP (1) EP3174991B1 (https=)
JP (1) JP6810023B2 (https=)
CN (1) CN107075539B (https=)
AU (1) AU2015296304B2 (https=)
CA (1) CA2955204A1 (https=)
ES (1) ES2978375T3 (https=)
WO (1) WO2016019140A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3056254A1 (en) * 2017-03-31 2018-10-04 Metabolon, Inc. Comprehensive and quantitative lipid and tocopherol analysis
JP7306676B2 (ja) * 2019-02-26 2023-07-11 国立大学法人九州大学 脂質プロファイリングシステム、脂質プロファイリング方法、及び脂質プロファイリングプログラム
EP3980788A4 (en) * 2019-06-04 2023-12-13 Avanti Polar Lipids, LLC UNIVERSAL QUANTITATIVE LIPID STANDARDS FOR USE IN LIPIDOMICS
CN110609097A (zh) * 2019-09-12 2019-12-24 谱尼测试集团股份有限公司 一种磷脂酰丝氨酸类化合物的筛查方法
CN116106283B (zh) * 2023-02-16 2025-07-29 清华大学 缩醛磷脂的荧光分析方法与应用
CN116879415A (zh) * 2023-05-25 2023-10-13 厦门市迈理奥科技有限公司 一种脂质组学分析内标及其用途和检测方法
CN121464343A (zh) * 2023-07-03 2026-02-03 株式会社岛津制作所 使用胆碱部分含有稳定同位素的溶血磷脂酰胆碱化合物的分析方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4224031A (en) * 1977-11-15 1980-09-23 Mee John M L CI Mass spectrometric analysis of physiologically active compounds
GB0128498D0 (en) * 2001-11-28 2002-01-23 Inst Of Child Health International standards for sphingolipids
EP1490076A4 (en) 2002-03-11 2010-01-06 Lipomics Technologies Inc Novel metabolic targets and markers
US7306952B2 (en) * 2002-06-26 2007-12-11 Washington University In St. Louis Molecular fingerprinting of triglycerides in biological samples by electrospray ionization tandem mass spectrometry
EP1644474B1 (en) * 2003-07-11 2012-06-27 Tatiana A. Egorova-Zachernyuk Compositions and methods for stable isotope labelling of biological compounds
CN100567967C (zh) * 2006-08-31 2009-12-09 华南理工大学 一种定量测定纸浆树脂中甘油三酯含量的方法
US20100159540A1 (en) * 2007-03-26 2010-06-24 Ana Rodriguez Synthesis of resolvins and intermediates, compounds prepared thereby, and uses thereof
WO2009153136A2 (en) * 2008-05-28 2009-12-23 Basf Se Means and methods for assessing liver toxicity
US8263413B1 (en) * 2008-10-17 2012-09-11 Andrew S Hansen Methods for analyzing lipids and membrane proteins in biological matter using stable isotopes and mass spectrometry
SG10201405975VA (en) 2009-10-01 2014-11-27 Phenomenome Discoveries Inc Serum-based biomarkers of pancreatic cancer and uses thereof for diseasedetection and diagnosis
EP2345897A1 (en) * 2010-01-18 2011-07-20 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Improved method for the detection of polyunsaturated fatty acids
CN101824064A (zh) * 2010-01-29 2010-09-08 上海化工研究院 一种13c标记胆甾醇羧酸酯的合成方法
GB201213127D0 (en) * 2012-07-24 2012-09-05 Univ Dundee Novel isotopic labelling method
US10705100B1 (en) * 2013-09-11 2020-07-07 HB Biotech, LLC Methods for analyzing lipids and membrane proteins in biological matter using stable isotopes and mass spectrometry
CN103743851B (zh) * 2014-02-14 2015-06-17 中国农业科学院油料作物研究所 一种食用油中甘油三酯的单柱二维液相色谱-质谱分析方法及其应用

Also Published As

Publication number Publication date
EP3174991A1 (en) 2017-06-07
WO2016019140A1 (en) 2016-02-04
CN107075539B (zh) 2021-11-12
US20170192023A1 (en) 2017-07-06
CN107075539A (zh) 2017-08-18
AU2015296304B2 (en) 2019-08-29
JP6810023B2 (ja) 2021-01-06
EP3174991B1 (en) 2024-03-20
JP2017524708A (ja) 2017-08-31
CA2955204A1 (en) 2016-02-04
AU2015296304A1 (en) 2017-02-02
EP3174991A4 (en) 2018-02-14
US11181535B2 (en) 2021-11-23

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