ES2973874T3 - Formas sólidas de ceftolozano y procesos para su preparación - Google Patents
Formas sólidas de ceftolozano y procesos para su preparaciónInfo
- Publication number
- ES2973874T3 ES2973874T3 ES17810740T ES17810740T ES2973874T3 ES 2973874 T3 ES2973874 T3 ES 2973874T3 ES 17810740 T ES17810740 T ES 17810740T ES 17810740 T ES17810740 T ES 17810740T ES 2973874 T3 ES2973874 T3 ES 2973874T3
- Authority
- ES
- Spain
- Prior art keywords
- ceftolozane
- processes
- preparation
- solid forms
- solid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- JHFNIHVVXRKLEF-DCZLAGFPSA-N ceftolozane Chemical compound CN1C(N)=C(NC(=O)NCCN)C=[N+]1CC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)C(=N/OC(C)(C)C([O-])=O)\C=3N=C(N)SN=3)[C@H]2SC1 JHFNIHVVXRKLEF-DCZLAGFPSA-N 0.000 title 1
- 229960002405 ceftolozane Drugs 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/48—Methylene radicals, substituted by hetero rings
- C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662345936P | 2016-06-06 | 2016-06-06 | |
| PCT/US2017/035345 WO2017213944A1 (en) | 2016-06-06 | 2017-06-01 | Solid forms of ceftolozane and processes for preparing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2973874T3 true ES2973874T3 (es) | 2024-06-24 |
Family
ID=60578076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17810740T Active ES2973874T3 (es) | 2016-06-06 | 2017-06-01 | Formas sólidas de ceftolozano y procesos para su preparación |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11542279B2 (es) |
| EP (1) | EP3468968B1 (es) |
| CN (1) | CN109195967A (es) |
| ES (1) | ES2973874T3 (es) |
| WO (1) | WO2017213944A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112321610B (zh) * | 2020-09-29 | 2022-04-19 | 湖南润星制药有限公司 | 硫酸头孢洛扎及其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY108872A (en) * | 1991-09-10 | 1996-11-30 | Bristol Myers Squibb Co | Preparation of a cephalosporin antibiotic using the syn-isomer of a thiazolyl intermediate. |
| CA2504730C (en) | 2002-10-30 | 2011-04-12 | Astellas Pharma Inc. | Cephem compounds |
| IN2015DN03113A (es) * | 2012-09-27 | 2015-10-02 | Cubist Pharm Inc | |
| WO2014152763A1 (en) | 2013-03-14 | 2014-09-25 | Cubist Pharmaceuticals, Inc. | Cephalosporin compositions and methods of manufacture |
| US20160228448A1 (en) | 2013-09-27 | 2016-08-11 | Merck Sharp & Dohme Corp. | Solid Forms of Ceftolozane |
| US8906898B1 (en) | 2013-09-27 | 2014-12-09 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
| WO2016025813A1 (en) * | 2014-08-15 | 2016-02-18 | Merck Sharp & Dohme Corp. | Intermediates in the synthesis of cephalosporin compounds |
| EP3180347B1 (en) | 2014-08-15 | 2020-09-23 | Merck Sharp & Dohme Corp. | Synthesis of cephalosporin compounds |
| WO2016028670A1 (en) | 2014-08-18 | 2016-02-25 | Merck Sharp & Dohme Corp. | Salt forms of ceftolozane |
| WO2016095860A1 (en) | 2014-12-18 | 2016-06-23 | Merck Sharp & Dohme Corp. | Pyrazolyl carboxylic acid and pyrazolyl urea derivative compounds |
| WO2016109259A2 (en) | 2014-12-30 | 2016-07-07 | Merck Sharp & Dohme Corp. | Synthesis of cephalosporin compounds |
-
2017
- 2017-06-01 ES ES17810740T patent/ES2973874T3/es active Active
- 2017-06-01 EP EP17810740.5A patent/EP3468968B1/en active Active
- 2017-06-01 WO PCT/US2017/035345 patent/WO2017213944A1/en unknown
- 2017-06-01 CN CN201780034670.7A patent/CN109195967A/zh active Pending
- 2017-06-01 US US16/304,955 patent/US11542279B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US11542279B2 (en) | 2023-01-03 |
| EP3468968B1 (en) | 2024-01-10 |
| EP3468968A1 (en) | 2019-04-17 |
| WO2017213944A1 (en) | 2017-12-14 |
| EP3468968A4 (en) | 2019-11-27 |
| US20220056045A1 (en) | 2022-02-24 |
| CN109195967A (zh) | 2019-01-11 |
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