ES297265A1 - Procedure for obtaining pyrimide- (5,4-d) -pirimidines replaced basically (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for obtaining substantially substituted pyrimido [5,4-d] pyrimidines of the general formula ** (See formula) ** where the substituents A represent hydrogen or, each time two to each other, a double bond, 1 to 3 of the substituents R1 to R3 represent a free or substituted amino group, a nitrogen atom member of an optionally substituted heterocyclic ring, hydrazino groups or free or substituted guanidino, and the remaining 0 to 2 of the radicals R1 to R3 represent a free or substituted hydroxyl group, an optionally substituted alkyl, aryl or aralkyl group, wherein R1 and R3 may also be hydrogen and R1 or R3 also be halogen- and its salts, characterized by being treated with reducing agents pyrimido [5,4-d] pyrimidines of the formula ** (See formula) ** where R1 to R3 have the meaning indicated above and R4 represents a free or substituted amino group, a nitrogen atom member of an optionally substituted heterocyclic ring, a free or substituted hydrazino or guanidino group, a free or substituted hydroxyl or mercapto group, no R 4 being any free hydroxyl group if at least one of the radicals R.sub.1 or R.sub.3 does not represent one of the above-mentioned basic groups, and the tetrahydrocompounds thus obtained of the general formula I, with oxidizing agents, can be converted to the aromatic compounds of the formula I, and the free compounds eventually become their salts. (Machine-translation by Google Translate, not legally binding)