ES297246A1 - Procedure for the preparation of new derivatives of alpha-hydroxy-carboxylic acids (Machine-translation by Google Translate, not legally binding)
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Procedure for the preparation of new derivatives of alpha-hydroxy-carboxylic acids (Machine-translation by Google Translate, not legally binding)
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Novartis AG
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JR Geigy AG
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Application filed by JR Geigy AGfiledCriticalJR Geigy AG
Publication of ES297246A1publicationCriticalpatent/ES297246A1/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
Process for the preparation of new derivatives of the alpha-hydroxycarboxylic acids, of the general formula I ** (See formula) ** where R1 means hydrogen or an aliphatic, cycloaliphatic, aromatic or araliphatic radical, R2 means hydrogen or a lower alkyl radical, which may also be linked with a lower alkyl radical R1 by forming a bivalent saturated aliphatic radical with 2 to 7 chain members and 2 to 9 carbon atoms, and R3 means a lower alkyl radical, hydrogen, a monovalent cation or the normal equivalent of a polyvalent cation, characterized by reacting a reactive ester of a hydroxylic compound of the general formula II ** (See formula) ** where R3 'means a lower alkyl radical and R1 and R2 have the meaning set forth above, with a reactive salt of 1-adamantanol; hydrolyzing, if desired, the alkyl ester of alpha- (adamant-1-oxy) -carboxylic acid obtained, converting it to the free acid or to a salt; and transform, if desired, the free acid or the salt in another salt with an inorganic or organic base or, if desired, decompose a racemic acid in its antipodes. (Machine-translation by Google Translate, not legally binding)
ES297246A1963-03-061964-03-05Procedure for the preparation of new derivatives of alpha-hydroxy-carboxylic acids (Machine-translation by Google Translate, not legally binding)
ExpiredES297246A1
(en)