ES2971073T3 - Método de distribución de líquidos y método de inmunoensayo - Google Patents
Método de distribución de líquidos y método de inmunoensayo Download PDFInfo
- Publication number
- ES2971073T3 ES2971073T3 ES19912567T ES19912567T ES2971073T3 ES 2971073 T3 ES2971073 T3 ES 2971073T3 ES 19912567 T ES19912567 T ES 19912567T ES 19912567 T ES19912567 T ES 19912567T ES 2971073 T3 ES2971073 T3 ES 2971073T3
- Authority
- ES
- Spain
- Prior art keywords
- sample
- reagent
- reactor
- reactors
- transport unit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000009826 distribution Methods 0.000 title claims abstract description 176
- 239000007788 liquid Substances 0.000 title claims abstract description 92
- 238000000034 method Methods 0.000 title claims abstract description 76
- 238000003018 immunoassay Methods 0.000 title claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 234
- 238000004140 cleaning Methods 0.000 claims abstract description 36
- 238000003860 storage Methods 0.000 claims description 79
- 238000012432 intermediate storage Methods 0.000 claims description 10
- 239000000523 sample Substances 0.000 description 349
- 238000012360 testing method Methods 0.000 description 63
- 238000002156 mixing Methods 0.000 description 40
- 230000033001 locomotion Effects 0.000 description 38
- 239000000376 reactant Substances 0.000 description 29
- 238000012546 transfer Methods 0.000 description 29
- 239000012470 diluted sample Substances 0.000 description 27
- 238000004458 analytical method Methods 0.000 description 23
- 230000008569 process Effects 0.000 description 21
- 238000012545 processing Methods 0.000 description 16
- 239000000203 mixture Substances 0.000 description 15
- 102000011923 Thyrotropin Human genes 0.000 description 13
- 108010061174 Thyrotropin Proteins 0.000 description 13
- 230000011664 signaling Effects 0.000 description 12
- 230000009471 action Effects 0.000 description 11
- 239000008280 blood Substances 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 11
- 238000000926 separation method Methods 0.000 description 10
- 238000010586 diagram Methods 0.000 description 9
- 238000011534 incubation Methods 0.000 description 9
- 239000006249 magnetic particle Substances 0.000 description 9
- 239000012898 sample dilution Substances 0.000 description 9
- 238000005406 washing Methods 0.000 description 9
- 239000003085 diluting agent Substances 0.000 description 8
- 238000003113 dilution method Methods 0.000 description 8
- 230000001965 increasing effect Effects 0.000 description 6
- 230000010355 oscillation Effects 0.000 description 6
- 238000011112 process operation Methods 0.000 description 6
- 238000005259 measurement Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 238000013461 design Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000004020 luminiscence type Methods 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 238000013019 agitation Methods 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 238000009739 binding Methods 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 1
- 230000004308 accommodation Effects 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- -1 labels Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 229940034208 thyroxine Drugs 0.000 description 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/0092—Scheduling
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00524—Mixing by agitating sample carrier
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/0092—Scheduling
- G01N2035/0094—Scheduling optimisation; experiment design
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/103—General features of the devices using disposable tips
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1032—Dilution or aliquotting
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910107418.5A CN111521772B (zh) | 2019-02-02 | 2019-02-02 | 液体分配方法和免疫分析方法 |
PCT/CN2019/082176 WO2020155388A1 (zh) | 2019-02-02 | 2019-04-11 | 液体分配方法和免疫分析方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2971073T3 true ES2971073T3 (es) | 2024-06-03 |
Family
ID=71841545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES19912567T Active ES2971073T3 (es) | 2019-02-02 | 2019-04-11 | Método de distribución de líquidos y método de inmunoensayo |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP3919914B1 (zh) |
CN (1) | CN111521772B (zh) |
ES (1) | ES2971073T3 (zh) |
WO (1) | WO2020155388A1 (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN118795127A (zh) * | 2023-04-13 | 2024-10-18 | 深圳市帝迈生物技术有限公司 | 血液分析仪 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0645631B1 (en) * | 1993-09-29 | 2001-11-28 | Becton, Dickinson and Company | Apparatus for and method of automatic sample testing |
JP3229498B2 (ja) * | 1994-09-21 | 2001-11-19 | シスメックス株式会社 | 検体の自動分析方法および装置 |
JP4593404B2 (ja) * | 2005-08-29 | 2010-12-08 | シスメックス株式会社 | 液体試料吸引監視方法及び装置、並びに液体試料分析装置 |
CN101169450B (zh) * | 2006-10-27 | 2012-06-27 | 深圳迈瑞生物医疗电子股份有限公司 | 全自动生化分析方法及装置 |
US8703492B2 (en) * | 2007-04-06 | 2014-04-22 | Qiagen Gaithersburg, Inc. | Open platform hybrid manual-automated sample processing system |
CN201429622Y (zh) * | 2009-06-29 | 2010-03-24 | 北京众驰伟业科技发展有限公司 | 全自动血凝仪四联杯装载及旋转盘加样、测试、退杯系统 |
CN102221626B (zh) * | 2010-04-14 | 2015-04-22 | 深圳迈瑞生物医疗电子股份有限公司 | 一种全自动生化分析仪及其工作方法 |
CN102335636B (zh) * | 2011-07-12 | 2013-07-31 | 英科新创(厦门)科技有限公司 | 一种非等量连续加样器 |
EP2972404B1 (en) * | 2013-03-15 | 2021-11-24 | Abbott Laboratories | Automated diagnostic analyzers having rear accessible track systems and related methods |
CN104597265A (zh) * | 2013-10-30 | 2015-05-06 | 苏州海路生物技术有限公司 | 全自动粪便分析仪 |
CN103760375B (zh) * | 2014-01-28 | 2015-03-18 | 桂林优利特医疗电子有限公司 | 改进的自动生化分析仪及其使用方法 |
ES2854880T3 (es) * | 2014-06-11 | 2021-09-23 | Hoffmann La Roche | Procedimiento y sistema para el análisis de diagnóstico in vitro |
CN105378478B (zh) * | 2014-07-01 | 2017-10-31 | 深圳迈瑞生物医疗电子股份有限公司 | 一种全血样本检测方法及血液检测仪 |
WO2016002394A1 (ja) * | 2014-07-02 | 2016-01-07 | 株式会社 日立ハイテクノロジーズ | 血液凝固検査装置 |
CN105388314B (zh) * | 2015-12-17 | 2017-09-12 | 嘉兴凯实生物科技有限公司 | 一种全自动加样仪 |
CN105618169B (zh) * | 2015-12-21 | 2017-06-16 | 安徽农业大学 | 一种等量连续点滴移液枪 |
CN106199024A (zh) * | 2016-08-17 | 2016-12-07 | 江苏英诺华医疗技术有限公司 | 全自动生化分析仪及生化检测系统 |
CN109142768B (zh) * | 2017-01-06 | 2022-12-27 | 深圳迎凯生物科技有限公司 | 自动分析装置及样本分析方法 |
CN108802408B (zh) * | 2017-04-28 | 2023-07-04 | 深圳迈瑞生物医疗电子股份有限公司 | 全自动样本分析仪的测试方法、全自动样本分析仪及存储介质 |
CN108061810A (zh) * | 2017-12-14 | 2018-05-22 | 江苏锐汗德医疗科技有限公司 | 一种全自动管式时间分辨免疫分析仪 |
CN207866715U (zh) * | 2017-12-28 | 2018-09-14 | 深圳市新产业生物医学工程股份有限公司 | 化学发光检测仪 |
CN207866714U (zh) * | 2017-12-28 | 2018-09-14 | 深圳市新产业生物医学工程股份有限公司 | 化学发光检测仪 |
CN207866716U (zh) * | 2017-12-28 | 2018-09-14 | 深圳市新产业生物医学工程股份有限公司 | 化学发光检测仪 |
-
2019
- 2019-02-02 CN CN201910107418.5A patent/CN111521772B/zh active Active
- 2019-04-11 EP EP19912567.5A patent/EP3919914B1/en active Active
- 2019-04-11 WO PCT/CN2019/082176 patent/WO2020155388A1/zh active Application Filing
- 2019-04-11 ES ES19912567T patent/ES2971073T3/es active Active
Also Published As
Publication number | Publication date |
---|---|
EP3919914A1 (en) | 2021-12-08 |
EP3919914A8 (en) | 2022-02-16 |
CN111521772A (zh) | 2020-08-11 |
EP3919914B1 (en) | 2023-11-29 |
EP3919914A4 (en) | 2022-03-30 |
WO2020155388A1 (zh) | 2020-08-06 |
CN111521772B (zh) | 2021-12-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2971073T3 (es) | Método de distribución de líquidos y método de inmunoensayo | |
ES2971958T3 (es) | Método de distribución de líquidos y método de inmunoensayo | |
WO2020155385A1 (zh) | 液体分配方法和免疫分析方法 | |
WO2020155389A1 (zh) | 样本稀释方法和免疫分析方法 | |
WO2020087238A1 (zh) | 反应装置和免疫分析仪 | |
CN111122894B (zh) | 试剂吸取方法、试剂供给装置及免疫分析仪 | |
WO2020155387A1 (zh) | 液体分配装置和免疫分析仪 | |
CN111122886B (zh) | 稀释方法、稀释装置及免疫分析仪 | |
CN111122888B (zh) | 混匀方法、混匀装置及免疫分析仪 | |
CN111122883B (zh) | 反应装置和免疫分析仪 | |
WO2020087256A1 (zh) | 试剂吸取方法、试剂供给装置及免疫分析仪 | |
WO2020087245A1 (zh) | 免疫分析方法 | |
WO2020087240A1 (zh) | 混匀方法、混匀装置及免疫分析仪 | |
WO2020087244A1 (zh) | 混匀方法、混匀装置及免疫分析仪 | |
WO2020087255A1 (zh) | 稀释方法、稀释装置及免疫分析仪 | |
WO2020087251A1 (zh) | 免疫分析仪 | |
CN111122889A (zh) | 免疫分析方法 | |
WO2020087252A1 (zh) | 反应装置和免疫分析仪 | |
CN111122884B (zh) | 反应装置和免疫分析仪 | |
CN111122887B (zh) | 混匀方法、混匀装置及免疫分析仪 | |
CN111122885A (zh) | 免疫分析仪 |