ES2964340T3 - Métodos para generar anticuerpos portadores de péptidos bioactivos y composiciones que comprenden los mismos - Google Patents
Métodos para generar anticuerpos portadores de péptidos bioactivos y composiciones que comprenden los mismos Download PDFInfo
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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| US201361962289P | 2013-03-15 | 2013-03-15 | |
| US201361823964P | 2013-05-16 | 2013-05-16 | |
| PCT/US2014/028999 WO2014144542A2 (en) | 2013-03-15 | 2014-03-14 | Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same |
Publications (1)
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| ES2964340T3 true ES2964340T3 (es) | 2024-04-05 |
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| EP (1) | EP2968546B1 (Direct) |
| JP (2) | JP2016514456A (Direct) |
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| CA (1) | CA2906096C (Direct) |
| ES (1) | ES2964340T3 (Direct) |
| NZ (2) | NZ729747A (Direct) |
| WO (1) | WO2014144542A2 (Direct) |
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| US20140363433A1 (en) * | 2013-03-15 | 2014-12-11 | Omeros Corporation | Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same |
| WO2014144542A2 (en) * | 2013-03-15 | 2014-09-18 | Omeros Corporation | Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same |
| CN107208315A (zh) * | 2014-12-01 | 2017-09-26 | 斯克利普斯研究院 | 涉及嵌入异源蛋白质支架中的功能性多肽的方法和组合物 |
| KR102528260B1 (ko) * | 2016-01-05 | 2023-05-04 | 유니버시티 오브 레스터 | 필요로 하는 대상체에서 섬유증의 억제 방법 |
| JOP20190068A1 (ar) * | 2016-10-13 | 2019-04-01 | Omeros Corp | طرق لتقليل البول البروتيني في خاضع بشري يعاني من الاعتلال الكلوي a الناتج عن الجلوبيولين المناعي |
| WO2018186322A1 (en) * | 2017-04-03 | 2018-10-11 | Chugai Seiyaku Kabushiki Kaisha | Anti-masp-1 antibodies and methods of use |
| EP3606952A1 (en) | 2017-04-07 | 2020-02-12 | Miltenyi Biotec GmbH | POLYPEPTIDES WITH MUTANT HUMAN IgG4 |
| KR20210008027A (ko) * | 2018-05-10 | 2021-01-20 | 미라바이오로직스 가부시키가이샤 | 항체의 항원 결합 영역을 포함하고, 생리 활성 펩티드를 융합하는 인공 단백질 |
| WO2020225095A1 (en) | 2019-05-07 | 2020-11-12 | Bayer Aktiengesellschaft | Masp inhibitory compounds and uses thereof |
| TWI867422B (zh) | 2020-03-06 | 2024-12-21 | 美商奥默羅斯公司 | 用於治療和/或預防流感病毒誘導的急性呼吸窘迫症候群、肺炎或者流感病毒感染的一些其它肺部表現的抑制masp-2的方法 |
| EP4240750A1 (en) | 2020-11-04 | 2023-09-13 | Bayer Aktiengesellschaft | Masp inhibitory compounds and uses thereof |
| EP4011904A1 (en) | 2020-12-14 | 2022-06-15 | Bayer Aktiengesellschaft | Masp inhibitory compounds and uses thereof |
| TW202305010A (zh) * | 2021-04-25 | 2023-02-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 抗ｍａｓｐ２抗體、其抗原結合片段及醫藥用途 |
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| US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5211657A (en) | 1988-11-07 | 1993-05-18 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US6765087B1 (en) | 1992-08-21 | 2004-07-20 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| US5837242A (en) | 1992-12-04 | 1998-11-17 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
| AU6796094A (en) | 1993-04-29 | 1994-11-21 | Raymond Hamers | Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of (camelidae) |
| US20050033033A1 (en) * | 1998-05-04 | 2005-02-10 | Heinz Kohler | Trans-membrane-antibody induced inhibition of apoptosis |
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| CA2490409A1 (en) * | 2002-06-28 | 2004-01-08 | Centocor, Inc. | Mammalian ch1 deleted mimetibodies, compositions, methods and uses |
| KR101101261B1 (ko) | 2002-07-19 | 2012-01-04 | 인스티튜트 오브 머티어리얼스 리서치 & 엔지니어링 | 생체분해성 삼블럭 공중합체, 이의 합성 방법, 및이로부터 제조된 하이드로겔 및 생체물질 |
| CA2518119A1 (en) * | 2003-03-05 | 2004-09-16 | Innexus Biotechnology Inc. | Trans-membrane-antibody induced inhibition of apoptosis |
| ES2541134T3 (es) * | 2003-05-12 | 2015-07-16 | Helion Biotech Aps | Anticuerpos de MASP-2 |
| US20130266559A1 (en) | 2004-06-10 | 2013-10-10 | University Of Leicester | Methods for Treating Conditions Associated with MASP-2 Dependent Complement Activation |
| US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| US7919094B2 (en) | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| EP1844073A1 (en) | 2005-01-31 | 2007-10-17 | Ablynx N.V. | Method for generating variable domain sequences of heavy chain antibodies |
| WO2007048022A2 (en) * | 2005-10-21 | 2007-04-26 | Alexion Pharmaceuticals, Inc. | Antibody-polypeptide fusion proteins and methods for producing and using same |
| PE20070684A1 (es) * | 2005-11-14 | 2007-08-06 | Amgen Inc | MOLECULAS QUIMERICAS DE ANTICUERPO RANKL-PTH/PTHrP |
| KR20080090406A (ko) | 2005-11-28 | 2008-10-08 | 젠맵 에이/에스 | 재조합 １가 항체 및 그의 제조 방법 |
| ES2628973T3 (es) | 2007-05-31 | 2017-08-04 | University Of Washington | Mutagénesis inducible de genes diana |
| US10369204B2 (en) | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
| WO2010136483A2 (en) * | 2009-05-28 | 2010-12-02 | Glaxo Group Limited | Antigen-binding proteins |
| EP2488203B1 (en) | 2009-10-16 | 2016-12-07 | Omeros Corporation | Methods for treating disseminated intravascular coagulation by inhibiting masp-2 dependent complement activation |
| WO2012000777A1 (en) | 2010-07-01 | 2012-01-05 | Thomson Licensing | Method for calibrating a band rejection filter of a terminal and multistandard terminal with calibrated band rejection filter |
| HUP1000366A2 (en) * | 2010-07-13 | 2012-03-28 | Mta Enzimologiai Intezet | Novel proteins, their production process and use tereof |
| CN110075294A (zh) * | 2011-04-08 | 2019-08-02 | 莱斯特大学 | 用于治疗与masp-2依赖性补体活化相关的状况的方法 |
| US9644035B2 (en) | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| EP3725811A3 (en) | 2011-05-04 | 2021-01-27 | Omeros Corporation | Compositions for inhibiting masp-2 dependent complement activation |
| CN103826659A (zh) * | 2011-06-20 | 2014-05-28 | 圣路易斯大学 | 用于治疗的靶向神经肌肉接头 |
| ES2894944T3 (es) * | 2012-04-06 | 2022-02-16 | Omeros Corp | Composiciones y métodos para inhibir la MASP-1 y/o la MASP-2 y/o la MASP-3 para el tratamiento de la hemoglobinuria nocturna paroxísmica |
| KR102339315B1 (ko) | 2012-06-18 | 2021-12-15 | 오메로스 코포레이션 | 다양한 질환 및 장애의 치료를 위해 masp-1 및/또는 masp-2 및/또는 masp-3를 억제하는 조성물 및 방법 |
| WO2014144542A2 (en) * | 2013-03-15 | 2014-09-18 | Omeros Corporation | Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same |
| US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
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2014
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- 2014-03-14 US US14/213,630 patent/US20150017162A1/en not_active Abandoned
- 2014-03-14 JP JP2016502958A patent/JP2016514456A/ja not_active Withdrawn
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- 2014-03-14 EP EP14764165.8A patent/EP2968546B1/en active Active
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- 2014-03-14 CA CA2906096A patent/CA2906096C/en active Active
- 2014-03-14 NZ NZ629682A patent/NZ629682A/en unknown
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2017
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2019
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2020
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2024
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| JP6615854B2 (ja) | 2019-12-04 |
| AU2017276336A1 (en) | 2018-01-18 |
| EP2968546B1 (en) | 2023-09-20 |
| EP2968546A2 (en) | 2016-01-20 |
| JP2018093875A (ja) | 2018-06-21 |
| WO2014144542A2 (en) | 2014-09-18 |
| AU2019226184A1 (en) | 2019-09-26 |
| NZ729747A (en) | 2020-03-27 |
| US20210079117A1 (en) | 2021-03-18 |
| AU2019226184B2 (en) | 2021-08-12 |
| CA2906096C (en) | 2022-03-15 |
| CA2906096A1 (en) | 2014-09-18 |
| JP2016514456A (ja) | 2016-05-23 |
| AU2014229020B2 (en) | 2017-09-28 |
| WO2014144542A3 (en) | 2014-12-31 |
| EP2968546A4 (en) | 2016-11-02 |
| AU2014229020A1 (en) | 2015-10-29 |
| US20250122309A1 (en) | 2025-04-17 |
| NZ629682A (en) | 2017-03-31 |
| US20150017162A1 (en) | 2015-01-15 |
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