ES295654A1 - Procedimiento para la fabricaciën de azapentanoles - Google Patents
Procedimiento para la fabricaciën de azapentanolesInfo
- Publication number
- ES295654A1 ES295654A1 ES0295654A ES295654A ES295654A1 ES 295654 A1 ES295654 A1 ES 295654A1 ES 0295654 A ES0295654 A ES 0295654A ES 295654 A ES295654 A ES 295654A ES 295654 A1 ES295654 A1 ES 295654A1
- Authority
- ES
- Spain
- Prior art keywords
- phenyl
- group
- azapentanol
- formula
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 150000003944 halohydrins Chemical class 0.000 abstract 2
- 125000005283 haloketone group Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- UJRMHKCFHTVNIY-UHFFFAOYSA-N 2-[2-(3,4-dimethoxyphenyl)ethylamino]-1-(3-methylphenyl)ethanol Chemical compound C1=C(OC)C(OC)=CC=C1CCNCC(O)C1=CC=CC(C)=C1 UJRMHKCFHTVNIY-UHFFFAOYSA-N 0.000 abstract 1
- NQPBHOQLYPMNKE-UHFFFAOYSA-N 4-[2-[[2-(3,4-dimethylphenyl)-2-hydroxyethyl]amino]ethyl]-2-methoxyphenol Chemical compound COC1=C(O)C=CC(CCNCC(O)C2=CC(C)=C(C)C=C2)=C1 NQPBHOQLYPMNKE-UHFFFAOYSA-N 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- 239000004593 Epoxy Substances 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 239000004411 aluminium Substances 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000003840 hydrochlorides Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000002440 hydroxy compounds Chemical class 0.000 abstract 1
- 230000036543 hypotension Effects 0.000 abstract 1
- 229960004592 isopropanol Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- 229940095064 tartrate Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3009/63A GB998288A (en) | 1963-01-24 | 1963-01-24 | Novel azapentanols and a process for the manufacture thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES295654A1 true ES295654A1 (es) | 1964-06-16 |
Family
ID=9750228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0295654A Expired ES295654A1 (es) | 1963-01-24 | 1964-01-23 | Procedimiento para la fabricaciën de azapentanoles |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3211792A (en, 2012) |
| BE (1) | BE642822A (en, 2012) |
| CH (1) | CH430750A (en, 2012) |
| DK (1) | DK107942C (en, 2012) |
| ES (1) | ES295654A1 (en, 2012) |
| FR (1) | FR3119M (en, 2012) |
| GB (1) | GB998288A (en, 2012) |
| NL (1) | NL302260A (en, 2012) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6401871A (en, 2012) * | 1964-02-27 | 1965-08-30 | ||
| US3335155A (en) * | 1964-06-02 | 1967-08-08 | Aerojet General Co | Nitro-containing epoxy compounds |
| DE1234707B (de) * | 1964-08-29 | 1967-02-23 | Degussa | Verfahren zur Herstellung von ungesaettigten Aminoverbindungen |
| US3883560A (en) * | 1973-07-05 | 1975-05-13 | Colgate Palmolive Co | Salicylamidophenethanolamines |
| DE3662521D1 (de) * | 1985-04-16 | 1989-04-27 | Hoffmann La Roche | Phenethanol amine derivatives |
| US6713651B1 (en) * | 1999-06-07 | 2004-03-30 | Theravance, Inc. | β2-adrenergic receptor agonists |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB789033A (en) * | 1954-10-23 | 1958-01-15 | Philips Nv | Improvements in or relating to substituted aralkyl-phenyl-alkylamines |
| US2900415A (en) * | 1954-12-14 | 1959-08-18 | Lakeside Lab Inc | Synthesized antispasmodic compounds |
| US2816059A (en) * | 1956-03-07 | 1957-12-10 | Lilly Co Eli | N-[beta-(o-chlorophenyl)-beta-(hydroxy)-ethyl] isopropyl amine, salts thereof, and compositions containing same |
| US3086021A (en) * | 1957-09-20 | 1963-04-16 | Lakeside Lab Inc | Tertiaryamino butynyl alcohols |
| US3079403A (en) * | 1960-09-19 | 1963-02-26 | Smith Kline French Lab | Process for preparing amines |
-
0
- NL NL302260D patent/NL302260A/xx unknown
-
1963
- 1963-01-24 GB GB3009/63A patent/GB998288A/en not_active Expired
- 1963-12-06 CH CH1495163A patent/CH430750A/de unknown
-
1964
- 1964-01-07 FR FR959493A patent/FR3119M/fr not_active Expired
- 1964-01-16 DK DK23264AA patent/DK107942C/da active
- 1964-01-16 US US338003A patent/US3211792A/en not_active Expired - Lifetime
- 1964-01-22 BE BE642822A patent/BE642822A/xx unknown
- 1964-01-23 ES ES0295654A patent/ES295654A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR3119M (en, 2012) | 1965-02-08 |
| GB998288A (en) | 1965-07-14 |
| CH430750A (de) | 1967-02-28 |
| NL302260A (en, 2012) | 1900-01-01 |
| BE642822A (en, 2012) | 1964-07-22 |
| US3211792A (en) | 1965-10-12 |
| DK107942C (da) | 1967-07-24 |
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