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Merck KGaA
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E Merck AG
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Application filed by E Merck AGfiledCriticalE Merck AG
Publication of ES295478A1publicationCriticalpatent/ES295478A1/en
Procedure for the preparation of 17alpha-alkoxy-steroids, from the pregnane series of formula I **(See formula)** in which R1 signifies H, methyl, F or Cl, and R2 signifies methyl, ethyl or propyl, which may be unsaturated in the 6.7 and/or 1,2 position. characterized in that a corresponding 17-alpha-hydroxy-steroid is etherified or the functionally altered keto group (s) in position 3 and/or 20 of a corresponding substituted steroid or the 3beta-group is released. hydroxy-5-ene or 3-keto-5-ene of an steroid otherwise substituted as indicated in formula I is transformed oxidatively or according to usual methods of acid or alkaline isomerization in the 3-keto-4- group ene, to which effect, in the case of acid isomerization, the keto groups may also exist in functionally altered form in the starting group and that eventually, according to usual isomerization methods, a radical present in the 6beta position in a final product of formula I is transferred to the 6alpha position and/or the 17alpha-alkoxy-steroid of formula I is dehydrogenated in the 6.7 position and/or in the 1,2 position, according to microbiological or chemical methods. (Machine-translation by Google Translate, not legally binding)
ES0295478A1963-01-191964-01-18Procedure for the preparation of 17alfa-alcoxy-steroids (Machine-translation by Google Translate, not legally binding)
ExpiredES295478A1
(en)
A procedure for preparing the 21-hydroxy steroids of the pregnan series esterified in the position 21. (Machine-translation by Google Translate, not legally binding)