ES2930029T3 - Péptidos de unión a integrina pegilados biterminales y métodos para su uso - Google Patents

Péptidos de unión a integrina pegilados biterminales y métodos para su uso Download PDF

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Publication number
ES2930029T3
ES2930029T3 ES15779171T ES15779171T ES2930029T3 ES 2930029 T3 ES2930029 T3 ES 2930029T3 ES 15779171 T ES15779171 T ES 15779171T ES 15779171 T ES15779171 T ES 15779171T ES 2930029 T3 ES2930029 T3 ES 2930029T3
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ES
Spain
Prior art keywords
peg
peptide
conjugate
integrin
avp6
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Active
Application number
ES15779171T
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English (en)
Spanish (es)
Inventor
Sven H Hausner
Julie L Sutcliffe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California Berkeley
University of California San Diego UCSD
Original Assignee
University of California Berkeley
University of California San Diego UCSD
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Application filed by University of California Berkeley, University of California San Diego UCSD filed Critical University of California Berkeley
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Publication of ES2930029T3 publication Critical patent/ES2930029T3/es
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ES15779171T 2014-04-15 2015-04-14 Péptidos de unión a integrina pegilados biterminales y métodos para su uso Active ES2930029T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461979997P 2014-04-15 2014-04-15
PCT/US2015/025700 WO2015160770A1 (en) 2014-04-15 2015-04-14 Bi-terminal pegylated integrin-binding peptides and methods of use thereof

Publications (1)

Publication Number Publication Date
ES2930029T3 true ES2930029T3 (es) 2022-12-05

Family

ID=54324485

Family Applications (1)

Application Number Title Priority Date Filing Date
ES15779171T Active ES2930029T3 (es) 2014-04-15 2015-04-14 Péptidos de unión a integrina pegilados biterminales y métodos para su uso

Country Status (8)

Country Link
US (3) US10919932B2 (cg-RX-API-DMAC7.html)
EP (1) EP3131566B1 (cg-RX-API-DMAC7.html)
JP (1) JP6789823B2 (cg-RX-API-DMAC7.html)
CN (1) CN106573031B (cg-RX-API-DMAC7.html)
AU (2) AU2015247833B2 (cg-RX-API-DMAC7.html)
CA (1) CA2945945C (cg-RX-API-DMAC7.html)
ES (1) ES2930029T3 (cg-RX-API-DMAC7.html)
WO (1) WO2015160770A1 (cg-RX-API-DMAC7.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
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CA2945945C (en) * 2014-04-15 2023-10-03 The Regents Of The University Of California Bi-terminal pegylated integrin-binding peptides and methods of use thereof
WO2016134164A1 (en) * 2015-02-18 2016-08-25 Memorial Sloan Kettering Cancer Center Methods of enhancing cerenkov luminescence using nanoparticles, and compositions related thereto
US11634470B2 (en) * 2015-10-23 2023-04-25 Jai Prakash Integrin binding peptides and uses thereof
JP7081832B2 (ja) * 2016-06-13 2022-06-07 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア α（Ｖ）β（６）インテグリン結合ペプチドおよびその使用方法
EP3471697B1 (en) * 2016-06-16 2024-09-04 The University of Liverpool Chemical composition
GB201613166D0 (en) 2016-07-29 2016-09-14 Vectura Ltd Polymer
KR102498068B1 (ko) * 2016-10-07 2023-02-09 도오쿄 인스티튜드 오브 테크놀로지 분기형 헤테로 단분산 폴리에틸렌 글리콜, 그 제조 방법, 및 그 결합체
JP7291624B2 (ja) * 2016-11-01 2023-06-15 アローヘッド ファーマシューティカルズ インコーポレイテッド アルファ－ｖベータ－６インテグリンリガンド及びその使用
GB201706472D0 (en) * 2017-04-24 2017-06-07 Cancer Res Tech Ltd Tumour-targeting peptide variants
BR112020006901A2 (pt) 2017-11-01 2020-10-13 Arrowhead Pharmaceuticals, Inc. ligantes de integrina e usos dos mesmos
EP3749416A1 (en) * 2018-02-06 2020-12-16 Klinikum rechts der Isar der Technischen Universität München Compound for intraoperative molecular bioimaging, method of making the same, use thereof in intraoperative molecular bioimaging and surgical method comprising intraoperative molecular bioimaging
WO2020051549A1 (en) 2018-09-07 2020-03-12 The Regents Of The University Of California Alpha(v)beta(6) integrin-binding peptides and methods of use thereof
WO2020093055A2 (en) 2018-11-02 2020-05-07 Indi Molecular, Inc. Peptide libraries with non-canonical amino acids
CN114206906B (zh) * 2019-07-10 2024-02-20 香港大学 Peg化的合成kl4肽、其组合物和方法
CN110522923A (zh) * 2019-09-19 2019-12-03 四川大学 果糖和rgd肽共修饰的双重靶向三阴性乳腺癌的脂质材料
WO2021067825A1 (en) * 2019-10-02 2021-04-08 Sirnaomics, Inc. Oligonucleotides with nucleoside analogs
CA3153354A1 (en) * 2019-10-25 2021-04-29 Anindya Roy Computational design of alpha(v) beta (6) integrin binding proteins
WO2021226432A2 (en) * 2020-05-08 2021-11-11 The Regents Of The University Of California Methods of detecting and treating lung damage in respiratory-related viral infections
US20230277490A1 (en) * 2020-07-31 2023-09-07 Cedars-Sinai Medical Center Glutamine as an anticancer therapy in solid tumors
EP4232093A4 (en) * 2020-10-20 2025-03-12 The Board Of Regents Of The University Of Texas System Proinflammatory prodrugs
WO2022098745A1 (en) * 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, delivery systems, and methods useful in tumor therapy
EP4319765A1 (en) 2021-04-08 2024-02-14 Arrowhead Pharmaceuticals, Inc. Rnai agents for inhibiting expression of receptor for advanced glycation end-products, compositions thereof, and methods of use
WO2024263637A1 (en) 2023-06-20 2024-12-26 The Regents Of The University Of California Combination therapy with peptide receptor radionuclide and dna repair inhibitor

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Also Published As

Publication number Publication date
AU2019232847B2 (en) 2020-08-27
WO2015160770A1 (en) 2015-10-22
US20170174723A1 (en) 2017-06-22
US11485758B2 (en) 2022-11-01
JP2017513859A (ja) 2017-06-01
AU2015247833B2 (en) 2019-10-10
JP6789823B2 (ja) 2020-11-25
US20240101601A1 (en) 2024-03-28
US10919932B2 (en) 2021-02-16
AU2019232847A1 (en) 2019-10-10
EP3131566A4 (en) 2017-11-08
CN106573031B (zh) 2021-05-28
CA2945945C (en) 2023-10-03
CN106573031A (zh) 2017-04-19
EP3131566B1 (en) 2022-10-05
AU2015247833A1 (en) 2016-11-10
US20210206804A1 (en) 2021-07-08
EP3131566A1 (en) 2017-02-22
CA2945945A1 (en) 2015-10-22

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