ES2911016T3 - Dispositivo de separación de fluidos biológicos - Google Patents
Dispositivo de separación de fluidos biológicos Download PDFInfo
- Publication number
- ES2911016T3 ES2911016T3 ES19734193T ES19734193T ES2911016T3 ES 2911016 T3 ES2911016 T3 ES 2911016T3 ES 19734193 T ES19734193 T ES 19734193T ES 19734193 T ES19734193 T ES 19734193T ES 2911016 T3 ES2911016 T3 ES 2911016T3
- Authority
- ES
- Spain
- Prior art keywords
- collection
- blood
- chamber
- separation device
- phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000926 separation method Methods 0.000 title claims abstract description 238
- 239000013060 biological fluid Substances 0.000 title description 4
- 239000008280 blood Substances 0.000 claims abstract description 294
- 210000004369 blood Anatomy 0.000 claims abstract description 294
- 230000004913 activation Effects 0.000 claims abstract description 57
- 238000004891 communication Methods 0.000 claims abstract description 38
- 239000012530 fluid Substances 0.000 claims abstract description 21
- 238000005192 partition Methods 0.000 claims abstract description 9
- 238000007789 sealing Methods 0.000 claims abstract description 5
- 239000012528 membrane Substances 0.000 claims description 10
- 230000001413 cellular effect Effects 0.000 claims description 4
- 230000036772 blood pressure Effects 0.000 description 14
- 238000000034 method Methods 0.000 description 14
- 230000008569 process Effects 0.000 description 12
- 206010018910 Haemolysis Diseases 0.000 description 7
- 230000008588 hemolysis Effects 0.000 description 7
- 230000005484 gravity Effects 0.000 description 6
- 230000017531 blood circulation Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000002405 diagnostic procedure Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000012123 point-of-care testing Methods 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 239000012491 analyte Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 208000004476 Acute Coronary Syndrome Diseases 0.000 description 2
- 206010051055 Deep vein thrombosis Diseases 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 238000009534 blood test Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000009295 crossflow filtration Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 208000010378 Pulmonary Embolism Diseases 0.000 description 1
- 206010047249 Venous thrombosis Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 230000005499 meniscus Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/15003—Source of blood for venous or arterial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150213—Venting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150251—Collection chamber divided into at least two compartments, e.g. for division of samples
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150351—Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
- A61B5/154—Devices using pre-evacuated means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Ecology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- External Artificial Organs (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Sampling And Sample Adjustment (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862681894P | 2018-06-07 | 2018-06-07 | |
| PCT/US2019/035761 WO2019236822A1 (en) | 2018-06-07 | 2019-06-06 | Biological fluid separation device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2911016T3 true ES2911016T3 (es) | 2022-05-17 |
Family
ID=67106145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES19734193T Active ES2911016T3 (es) | 2018-06-07 | 2019-06-06 | Dispositivo de separación de fluidos biológicos |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12076146B2 (https=) |
| EP (2) | EP4001916B1 (https=) |
| JP (2) | JP7671144B2 (https=) |
| KR (1) | KR102512973B1 (https=) |
| CN (1) | CN112400111B (https=) |
| AU (1) | AU2019282329B2 (https=) |
| BR (1) | BR112020024796A2 (https=) |
| CA (1) | CA3102269C (https=) |
| ES (1) | ES2911016T3 (https=) |
| MX (1) | MX2020013202A (https=) |
| WO (1) | WO2019236822A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2026006069A1 (en) * | 2024-06-26 | 2026-01-02 | Becton, Dickinson And Company | System for point-of-care blood sampling and centrifuge-free plasma or serum separation |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3678946D1 (de) * | 1985-08-27 | 1991-05-29 | Seovac Ab | Verfahren und vorrichtung zur trennung von serum und plasma aus blut. |
| US20020049391A1 (en) * | 1997-04-08 | 2002-04-25 | Kuracina Thomas C. | Method and apparatus for collecting blood |
| CN2442270Y (zh) * | 2000-09-12 | 2001-08-08 | 淄博中保康医疗器具有限公司 | 血浆单采离心分离器 |
| US6755802B2 (en) * | 2002-05-06 | 2004-06-29 | Beckman Coulter, Inc. | Whole blood sampling device |
| CN100492006C (zh) * | 2002-11-19 | 2009-05-27 | 积水医疗株式会社 | 过滤仪及血液检测容器 |
| JP4113464B2 (ja) * | 2003-06-16 | 2008-07-09 | 積水化学工業株式会社 | 血液検査用容器及び血液検査方法 |
| TW200519382A (en) * | 2003-11-21 | 2005-06-16 | Vasogen Ireland Ltd | Medical material handling systems |
| EP1697743B1 (en) * | 2003-12-24 | 2009-03-11 | Becton, Dickinson and Company | Plasma on demand tube |
| JP3890066B2 (ja) * | 2005-06-27 | 2007-03-07 | 積水化学工業株式会社 | 血液分離器具及び血液分離装置 |
| JP2007000537A (ja) | 2005-06-27 | 2007-01-11 | Sekisui Chem Co Ltd | 真空検体採取器具 |
| US20080017577A1 (en) * | 2006-07-21 | 2008-01-24 | Becton, Dickinson And Company | Membrane-based Double-layer Tube for Sample Collections |
| JP2008059888A (ja) | 2006-08-31 | 2008-03-13 | Ushio Inc | エキシマランプ |
| KR100843339B1 (ko) * | 2006-12-07 | 2008-07-03 | 한국전자통신연구원 | 혈액 중의 혈장 분리를 위하여 마이크로채널을 이용한혈장분리기 및 이에 의한 혈장분리방법 |
| JP2008279195A (ja) * | 2007-05-14 | 2008-11-20 | Sekisui Chem Co Ltd | 血液分離フィルタ装置 |
| US8562908B2 (en) | 2007-06-29 | 2013-10-22 | Baxter International Inc. | Devices, systems, and methods for cleaning, disinfecting, rinsing, and priming blood separation devices and associated fluid lines |
| CA2784287C (en) * | 2009-12-22 | 2017-07-18 | Evonik Degussa Corporation | Emulsion-based process for preparing microparticles and workhead assembly for use with same |
| US9162186B2 (en) * | 2011-07-22 | 2015-10-20 | Chromedx Corp. | Sample filtration assembly |
| US8741234B2 (en) * | 2011-12-27 | 2014-06-03 | Honeywell International Inc. | Disposable cartridge for fluid analysis |
| EP2695655A1 (de) * | 2012-08-09 | 2014-02-12 | F. Hoffmann-La Roche AG | Mehrteilige Vorrichtung zur Gewinnung von Plasma aus Vollblut |
| EP2695652A1 (de) * | 2012-08-09 | 2014-02-12 | F. Hoffmann-La Roche AG | System zur Abtrennung von Plasma aus Vollblut |
| US9427707B2 (en) | 2012-08-10 | 2016-08-30 | Jean I. Montagu | Filtering blood |
| US10772548B2 (en) * | 2012-12-04 | 2020-09-15 | Magnolia Medical Technologies, Inc. | Sterile bodily-fluid collection device and methods |
| CA2909233C (en) * | 2013-04-15 | 2019-10-22 | Becton, Dickinson And Company | Biological fluid separation device and biological fluid separation and testing system |
| CA2909229C (en) | 2013-04-15 | 2020-08-18 | Becton, Dickinson And Company | Biological fluid collection device and biological fluid separation and testing system |
| ES2654897T3 (es) * | 2013-04-15 | 2018-02-15 | Becton, Dickinson And Company | Sistema de separación y de análisis de fluidos biológicos |
| CA3005826C (en) | 2013-04-15 | 2021-11-23 | Becton, Dickinson And Company | Biological fluid collection device and biological fluid separation and testing system |
| DE102013012676A1 (de) | 2013-07-31 | 2015-02-05 | Mann + Hummel Gmbh | Vorrichtung zur Querstromfiltration |
| MY188120A (en) | 2014-06-13 | 2021-11-22 | Michael Ryan Mcneely | Capillary pressure re-set mechanism and applications |
| CN106604780B (zh) * | 2015-03-10 | 2019-06-25 | 贝克顿·迪金森公司 | 生物流体微样本管理装置 |
| WO2016205779A2 (en) * | 2015-06-19 | 2016-12-22 | Becton, Dickinson And Company | Biological fluid collection device |
| PL3311160T3 (pl) * | 2015-06-20 | 2021-09-13 | Capitainer Ab | Urządzenie mikroprzepływowe do rozdzielania osocza |
| ES2796491T3 (es) | 2015-08-06 | 2020-11-27 | Becton Dickinson Co | Dispositivo de recogida de fluidos biológicos |
| EP3469358B1 (en) * | 2016-06-09 | 2025-10-22 | Becton, Dickinson and Company | Biological fluid separation device |
| CN106108920A (zh) * | 2016-08-23 | 2016-11-16 | 郭小兵 | 一种适用于医学试验的负压抽滤式血浆采集装置 |
| CN107702973B (zh) * | 2017-09-08 | 2024-07-26 | 深圳市太赫兹科技创新研究院有限公司 | 一种全血血浆分离系统及方法 |
| EP3681384B1 (en) * | 2017-09-12 | 2022-12-28 | Magnolia Medical Technologies, Inc. | A system |
-
2019
- 2019-06-06 AU AU2019282329A patent/AU2019282329B2/en active Active
- 2019-06-06 CA CA3102269A patent/CA3102269C/en active Active
- 2019-06-06 US US17/059,598 patent/US12076146B2/en active Active
- 2019-06-06 BR BR112020024796-0A patent/BR112020024796A2/pt unknown
- 2019-06-06 MX MX2020013202A patent/MX2020013202A/es unknown
- 2019-06-06 KR KR1020217000439A patent/KR102512973B1/ko active Active
- 2019-06-06 CN CN201980046904.9A patent/CN112400111B/zh active Active
- 2019-06-06 JP JP2020567792A patent/JP7671144B2/ja active Active
- 2019-06-06 WO PCT/US2019/035761 patent/WO2019236822A1/en not_active Ceased
- 2019-06-06 EP EP22151355.9A patent/EP4001916B1/en active Active
- 2019-06-06 EP EP19734193.6A patent/EP3803389B1/en active Active
- 2019-06-06 ES ES19734193T patent/ES2911016T3/es active Active
-
2022
- 2022-11-21 JP JP2022185650A patent/JP7512356B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US12076146B2 (en) | 2024-09-03 |
| WO2019236822A1 (en) | 2019-12-12 |
| AU2019282329B2 (en) | 2022-06-30 |
| US20210161448A1 (en) | 2021-06-03 |
| CA3102269A1 (en) | 2019-12-12 |
| KR20210018917A (ko) | 2021-02-18 |
| JP7512356B2 (ja) | 2024-07-08 |
| CN112400111B (zh) | 2024-10-22 |
| JP2023026421A (ja) | 2023-02-24 |
| JP2021526878A (ja) | 2021-10-11 |
| KR102512973B1 (ko) | 2023-03-22 |
| CA3102269C (en) | 2023-03-14 |
| EP4001916A1 (en) | 2022-05-25 |
| AU2019282329A1 (en) | 2021-01-28 |
| JP7671144B2 (ja) | 2025-05-01 |
| MX2020013202A (es) | 2021-02-26 |
| EP3803389B1 (en) | 2022-01-26 |
| BR112020024796A2 (pt) | 2021-03-02 |
| EP4001916B1 (en) | 2024-11-20 |
| CN112400111A (zh) | 2021-02-23 |
| EP3803389A1 (en) | 2021-04-14 |
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