ES2908757T3 - Instrumento electroquirúrgico para realizar la ablación o la electroporación de tejido biológico - Google Patents
Instrumento electroquirúrgico para realizar la ablación o la electroporación de tejido biológico Download PDFInfo
- Publication number
- ES2908757T3 ES2908757T3 ES18730296T ES18730296T ES2908757T3 ES 2908757 T3 ES2908757 T3 ES 2908757T3 ES 18730296 T ES18730296 T ES 18730296T ES 18730296 T ES18730296 T ES 18730296T ES 2908757 T3 ES2908757 T3 ES 2908757T3
- Authority
- ES
- Spain
- Prior art keywords
- transmission line
- electroporation
- electrosurgical instrument
- electrosurgical
- coaxial transmission
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000005540 biological transmission Effects 0.000 claims abstract description 82
- 238000004520 electroporation Methods 0.000 claims abstract description 67
- 239000004020 conductor Substances 0.000 claims abstract description 38
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- 230000005684 electric field Effects 0.000 claims abstract description 11
- 239000003989 dielectric material Substances 0.000 claims abstract description 4
- 239000002086 nanomaterial Substances 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 description 17
- 230000002427 irreversible effect Effects 0.000 description 12
- 239000011148 porous material Substances 0.000 description 8
- 238000002679 ablation Methods 0.000 description 7
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1485—Probes or electrodes therefor having a short rigid shaft for accessing the inner body through natural openings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00059—Material properties
- A61B2018/00071—Electrical conductivity
- A61B2018/00077—Electrical conductivity high, i.e. electrically conducting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/0016—Energy applicators arranged in a two- or three dimensional array
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00541—Lung or bronchi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00613—Irreversible electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00702—Power or energy
- A61B2018/00708—Power or energy switching the power on or off
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00732—Frequency
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00982—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00994—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combining two or more different kinds of non-mechanical energy or combining one or more non-mechanical energies with ultrasound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1467—Probes or electrodes therefor using more than two electrodes on a single probe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1497—Electrodes covering only part of the probe circumference
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
- A61B2018/1823—Generators therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
- A61B2018/183—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves characterised by the type of antenna
- A61B2018/1853—Monopole antennas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
- A61B2018/1861—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves with an instrument inserted into a body lumen or cavity, e.g. a catheter
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Otolaryngology (AREA)
- Plasma & Fusion (AREA)
- Electromagnetism (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Radiology & Medical Imaging (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1709134.9A GB2563386A (en) | 2017-06-08 | 2017-06-08 | Electrosurgical instrument |
| PCT/EP2018/064467 WO2018224404A1 (en) | 2017-06-08 | 2018-06-01 | Electrosurgical instrument for performing ablation or electroporation of biological tissue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2908757T3 true ES2908757T3 (es) | 2022-05-03 |
Family
ID=59358379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18730296T Active ES2908757T3 (es) | 2017-06-08 | 2018-06-01 | Instrumento electroquirúrgico para realizar la ablación o la electroporación de tejido biológico |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11969208B2 (OSRAM) |
| EP (1) | EP3634289B1 (OSRAM) |
| JP (1) | JP7188778B2 (OSRAM) |
| KR (1) | KR20200016832A (OSRAM) |
| CN (1) | CN110545744B (OSRAM) |
| AU (1) | AU2018279116A1 (OSRAM) |
| BR (1) | BR112019021878A2 (OSRAM) |
| CA (1) | CA3060148A1 (OSRAM) |
| ES (1) | ES2908757T3 (OSRAM) |
| GB (1) | GB2563386A (OSRAM) |
| PT (1) | PT3634289T (OSRAM) |
| SG (1) | SG11201909915PA (OSRAM) |
| WO (1) | WO2018224404A1 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019084317A1 (en) * | 2017-10-26 | 2019-05-02 | Boston Scientific Scimed Inc. | USE OF ELECTROMAGNETIC FIELDS IN IRREVERSIBLE ELECTROPORATION DELIVERY DEVICES AND THERAPY MONITORING |
| US11944372B2 (en) * | 2018-10-23 | 2024-04-02 | Boston Scientific Scimed, Inc. | Ablation probe system with center working channel |
| GB2579644A (en) | 2018-12-10 | 2020-07-01 | Creo Medical Ltd | A modular electrosurgical system, and modules for said system |
| GB201906172D0 (en) | 2019-05-02 | 2019-06-19 | Univ College Cardiff Consultants Ltd | Device and method to induce cell death |
| EP4427693B1 (en) | 2019-09-02 | 2026-04-15 | Mirai Medical Limited | An electroporation apparatus |
| US11660135B2 (en) * | 2019-12-05 | 2023-05-30 | Biosense Webster (Israel) Ltd. | Generating and interleaving of irreversible-electroporation and radiofrequnecy ablation (IRE/RFA) waveforms |
| EP4138696A4 (en) * | 2020-04-22 | 2024-05-08 | Boston Scientific Medical Device Limited | LACERATION SYSTEM AND DEVICE AND LACERATION METHODS |
| US12076071B2 (en) | 2020-08-14 | 2024-09-03 | Kardium Inc. | Systems and methods for treating tissue with pulsed field ablation |
| US20230338731A1 (en) * | 2020-10-07 | 2023-10-26 | Northwestern University | Integration of electrophysiology mapping systems with electroporation synchronized with pacing |
| US12290306B2 (en) * | 2020-10-19 | 2025-05-06 | Biosense Webster (Israel) Ltd. | Using unipolar configuration for irreversible-electroporation (IRE) |
| WO2025188950A1 (en) * | 2024-03-07 | 2025-09-12 | St. Jude Medical, Cardiology Division, Inc. | Systems and methods for pulsed field ablation using low voltage, long duration pulses |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4204549A (en) | 1977-12-12 | 1980-05-27 | Rca Corporation | Coaxial applicator for microwave hyperthermia |
| US5697882A (en) * | 1992-01-07 | 1997-12-16 | Arthrocare Corporation | System and method for electrosurgical cutting and ablation |
| US5788692A (en) * | 1995-06-30 | 1998-08-04 | Fidus Medical Technology Corporation | Mapping ablation catheter |
| US5800494A (en) * | 1996-08-20 | 1998-09-01 | Fidus Medical Technology Corporation | Microwave ablation catheters having antennas with distal fire capabilities |
| US20070066972A1 (en) * | 2001-11-29 | 2007-03-22 | Medwaves, Inc. | Ablation catheter apparatus with one or more electrodes |
| GB9904373D0 (en) * | 1999-02-25 | 1999-04-21 | Microsulis Plc | Radiation applicator |
| US7344532B2 (en) * | 2001-08-27 | 2008-03-18 | Gyrus Medical Limited | Electrosurgical generator and system |
| US7653438B2 (en) * | 2002-04-08 | 2010-01-26 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
| US10245098B2 (en) * | 2008-04-29 | 2019-04-02 | Virginia Tech Intellectual Properties, Inc. | Acute blood-brain barrier disruption using electrical energy based therapy |
| US8133222B2 (en) * | 2008-05-28 | 2012-03-13 | Medwaves, Inc. | Tissue ablation apparatus and method using ultrasonic imaging |
| US8679106B2 (en) * | 2008-07-01 | 2014-03-25 | Medwaves, Inc. | Angioplasty and tissue ablation apparatus and method |
| US20140358140A1 (en) * | 2008-10-21 | 2014-12-04 | Microcube, Llc | Microwave treatment devices and methods |
| US9795442B2 (en) * | 2008-11-11 | 2017-10-24 | Shifamed Holdings, Llc | Ablation catheters |
| US20100152725A1 (en) * | 2008-12-12 | 2010-06-17 | Angiodynamics, Inc. | Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation |
| US8632534B2 (en) * | 2009-04-03 | 2014-01-21 | Angiodynamics, Inc. | Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD) |
| US8934989B2 (en) * | 2009-04-15 | 2015-01-13 | Medwaves, Inc. | Radio frequency based ablation system and method with dielectric transformer |
| EP2432412A2 (en) * | 2009-05-20 | 2012-03-28 | Herlev Hospital | Electroporation device with improved tip and electrode support |
| US9061134B2 (en) * | 2009-09-23 | 2015-06-23 | Ripple Llc | Systems and methods for flexible electrodes |
| US8764744B2 (en) * | 2010-01-25 | 2014-07-01 | Covidien Lp | System for monitoring ablation size |
| WO2011161474A1 (en) * | 2010-06-24 | 2011-12-29 | Emcision Limited | Enhanced ablation apparatus |
| US9289606B2 (en) * | 2010-09-02 | 2016-03-22 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System for electroporation therapy |
| US8974450B2 (en) * | 2011-02-03 | 2015-03-10 | Covidien Lp | System and method for ablation procedure monitoring using electrodes |
| US9233241B2 (en) * | 2011-02-28 | 2016-01-12 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices and methods |
| US20130030430A1 (en) * | 2011-07-29 | 2013-01-31 | Stewart Mark T | Intracardiac tools and methods for delivery of electroporation therapies |
| WO2013028425A1 (en) * | 2011-08-19 | 2013-02-28 | Cook Medical Technologies Llc | Ablation cap |
| US10070914B2 (en) * | 2011-12-20 | 2018-09-11 | Old Dominion University Research Foundation | Electromanipulation of cells and other biological tissues by pulsed electric fields at elevated temperatures |
| US9370311B2 (en) * | 2012-08-17 | 2016-06-21 | Medtronic Ablation Frontiers Llc | Electrophysiology catheter design |
| US9801681B2 (en) * | 2012-08-17 | 2017-10-31 | Medtronic Ablation Frontiers Llc | Catheters and methods for intracardiac electrical mapping |
| US9113911B2 (en) * | 2012-09-06 | 2015-08-25 | Medtronic Ablation Frontiers Llc | Ablation device and method for electroporating tissue cells |
| US10363359B2 (en) * | 2012-12-09 | 2019-07-30 | Autonomix Medical, Inc. | Systems and methods for regulating organ and/or tumor growth rates, function, and/or development |
| US9179971B2 (en) * | 2013-02-11 | 2015-11-10 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Printed electrode catheter |
| US9675263B2 (en) * | 2013-02-25 | 2017-06-13 | Medtronic Cryocath Lp | Retractable mapping jacket |
| US10835311B2 (en) * | 2014-10-24 | 2020-11-17 | Northwestern University | Electroporation apparatus and method of using same for ablation of an arbitrary volume |
| US20160278851A1 (en) * | 2015-03-23 | 2016-09-29 | Medtronic Cryocath Lp | Steerable catheter having pull wires affixed within the distal portion of the catheter |
| JP2018509227A (ja) * | 2015-03-25 | 2018-04-05 | ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． | 治療部位を識別するための方法及びデバイス |
| WO2016193403A1 (en) * | 2015-06-02 | 2016-12-08 | Oblique Therapeutics Ab | Electroporation device |
| WO2017008020A1 (en) * | 2015-07-08 | 2017-01-12 | The Johns Hopkins University | Tissue ablation and assessment system and method of use thereof |
| US10660691B2 (en) * | 2015-10-07 | 2020-05-26 | Angiodynamics, Inc. | Multiple use subassembly with integrated fluid delivery system for use with single or dual-lumen peristaltic tubing |
| US20170105793A1 (en) * | 2015-10-15 | 2017-04-20 | Boston Scientific Scimed, Inc. | Energy delivery devices and related methods of use |
| WO2017075067A1 (en) * | 2015-10-26 | 2017-05-04 | Neuwave Medical, Inc. | Energy delivery systems and uses thereof |
| US10188449B2 (en) * | 2016-05-23 | 2019-01-29 | Covidien Lp | System and method for temperature enhanced irreversible electroporation |
| US10898262B2 (en) * | 2016-10-25 | 2021-01-26 | Biosense Webster (Israel) Ltd. | Catheter distal end made of plastic tube and flexible printed circuit boards |
-
2017
- 2017-06-08 GB GB1709134.9A patent/GB2563386A/en not_active Withdrawn
-
2018
- 2018-06-01 JP JP2019561164A patent/JP7188778B2/ja active Active
- 2018-06-01 US US16/662,889 patent/US11969208B2/en active Active
- 2018-06-01 EP EP18730296.3A patent/EP3634289B1/en active Active
- 2018-06-01 WO PCT/EP2018/064467 patent/WO2018224404A1/en not_active Ceased
- 2018-06-01 CN CN201880026791.1A patent/CN110545744B/zh active Active
- 2018-06-01 PT PT187302963T patent/PT3634289T/pt unknown
- 2018-06-01 KR KR1020197030547A patent/KR20200016832A/ko not_active Ceased
- 2018-06-01 AU AU2018279116A patent/AU2018279116A1/en not_active Abandoned
- 2018-06-01 CA CA3060148A patent/CA3060148A1/en active Pending
- 2018-06-01 ES ES18730296T patent/ES2908757T3/es active Active
- 2018-06-01 SG SG11201909915P patent/SG11201909915PA/en unknown
- 2018-06-01 BR BR112019021878-5A patent/BR112019021878A2/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN110545744A (zh) | 2019-12-06 |
| JP7188778B2 (ja) | 2022-12-13 |
| EP3634289B1 (en) | 2022-02-16 |
| GB201709134D0 (en) | 2017-07-26 |
| JP2020523048A (ja) | 2020-08-06 |
| US20200367965A1 (en) | 2020-11-26 |
| CA3060148A1 (en) | 2018-12-13 |
| AU2018279116A1 (en) | 2019-11-07 |
| BR112019021878A2 (pt) | 2020-05-26 |
| US11969208B2 (en) | 2024-04-30 |
| PT3634289T (pt) | 2022-03-18 |
| WO2018224404A1 (en) | 2018-12-13 |
| EP3634289A1 (en) | 2020-04-15 |
| SG11201909915PA (en) | 2019-11-28 |
| CN110545744B (zh) | 2022-06-10 |
| KR20200016832A (ko) | 2020-02-17 |
| GB2563386A (en) | 2018-12-19 |
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