ES2907714T3 - Antagonistas de EP4 - Google Patents

Antagonistas de EP4 Download PDF

Info

Publication number
ES2907714T3
ES2907714T3 ES16790486T ES16790486T ES2907714T3 ES 2907714 T3 ES2907714 T3 ES 2907714T3 ES 16790486 T ES16790486 T ES 16790486T ES 16790486 T ES16790486 T ES 16790486T ES 2907714 T3 ES2907714 T3 ES 2907714T3
Authority
ES
Spain
Prior art keywords
trifluoromethyl
pyrazole
imidazo
dihydro
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES16790486T
Other languages
English (en)
Spanish (es)
Inventor
Wanjun Zheng
Xiaojie Zhu
Hong Du
Maarten Postema
Yimin Jiang
Jing Li
Robert Yu
Hyeong-Wook Choi
Jaemoon Lee
Frank Fang
Daniel Custar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai R&D Management Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co Ltd filed Critical Eisai R&D Management Co Ltd
Priority claimed from PCT/US2016/057135 external-priority patent/WO2017066633A1/en
Application granted granted Critical
Publication of ES2907714T3 publication Critical patent/ES2907714T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES16790486T 2015-10-16 2016-10-14 Antagonistas de EP4 Active ES2907714T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562242748P 2015-10-16 2015-10-16
US201562242734P 2015-10-16 2015-10-16
BD2522016 2016-10-13
PCT/US2016/057135 WO2017066633A1 (en) 2015-10-16 2016-10-14 Ep4 antagonists

Publications (1)

Publication Number Publication Date
ES2907714T3 true ES2907714T3 (es) 2022-04-26

Family

ID=79174569

Family Applications (1)

Application Number Title Priority Date Filing Date
ES16790486T Active ES2907714T3 (es) 2015-10-16 2016-10-14 Antagonistas de EP4

Country Status (2)

Country Link
ES (1) ES2907714T3 (ru)
RU (1) RU2761341C2 (ru)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004277337A (ja) * 2003-03-14 2004-10-07 Sumitomo Pharmaceut Co Ltd ピラゾロ［１，５−ａ］ピリミジン誘導体
WO2007121578A1 (en) * 2006-04-24 2007-11-01 Merck Frosst Canada Ltd. Indole amide derivatives as ep4 receptor antagonists
CA2733247C (en) * 2008-08-14 2018-04-03 Beta Pharma Canada Inc. Heterocyclic amide derivatives as ep4 receptor antagonists
ES2540867T3 (es) * 2010-02-26 2015-07-14 Mitsubishi Tanabe Pharma Corporation Compuestos de pirazolopirimidina y su uso como inhibidores de PDE10

Also Published As

Publication number Publication date
RU2761341C2 (ru) 2021-12-07
RU2018117887A (ru) 2019-11-18
RU2018117887A3 (ru) 2020-02-19

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