ES2881810T3 - Seguimiento de la recurrencia y progresión del cáncer - Google Patents
Seguimiento de la recurrencia y progresión del cáncer Download PDFInfo
- Publication number
- ES2881810T3 ES2881810T3 ES17784992T ES17784992T ES2881810T3 ES 2881810 T3 ES2881810 T3 ES 2881810T3 ES 17784992 T ES17784992 T ES 17784992T ES 17784992 T ES17784992 T ES 17784992T ES 2881810 T3 ES2881810 T3 ES 2881810T3
- Authority
- ES
- Spain
- Prior art keywords
- cancer
- metastasis
- superoxide
- chemiluminescence
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 119
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- 206010027476 Metastases Diseases 0.000 claims abstract description 34
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- PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 claims abstract description 24
- 239000000411 inducer Substances 0.000 claims abstract description 20
- HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 claims abstract description 18
- 230000004936 stimulating effect Effects 0.000 claims abstract description 10
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- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 1
- PHEDXBVPIONUQT-UHFFFAOYSA-N Cocarcinogen A1 Natural products CCCCCCCCCCCCCC(=O)OC1C(C)C2(O)C3C=C(C)C(=O)C3(O)CC(CO)=CC2C2C1(OC(C)=O)C2(C)C PHEDXBVPIONUQT-UHFFFAOYSA-N 0.000 description 1
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- 241000124008 Mammalia Species 0.000 description 1
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- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
- 208000006265 Renal cell carcinoma Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 230000016571 aggressive behavior Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
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- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 230000009699 differential effect Effects 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 231100000371 dose-limiting toxicity Toxicity 0.000 description 1
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- 238000001378 electrochemiluminescence detection Methods 0.000 description 1
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- 206010017758 gastric cancer Diseases 0.000 description 1
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- 201000003911 head and neck carcinoma Diseases 0.000 description 1
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- 238000002595 magnetic resonance imaging Methods 0.000 description 1
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- 208000037819 metastatic cancer Diseases 0.000 description 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 description 1
- 239000013586 microbial product Substances 0.000 description 1
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- 238000011275 oncology therapy Methods 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
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- 102000003390 tumor necrosis factor Human genes 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physiology (AREA)
- Ecology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1616640.7A GB201616640D0 (en) | 2016-09-30 | 2016-09-30 | Monitoring cancer recurrence and progression |
| PCT/GB2017/052947 WO2018060741A1 (en) | 2016-09-30 | 2017-10-02 | Monitoring cancer recurrence and progression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2881810T3 true ES2881810T3 (es) | 2021-11-30 |
Family
ID=57570942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17784992T Active ES2881810T3 (es) | 2016-09-30 | 2017-10-02 | Seguimiento de la recurrencia y progresión del cáncer |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11435341B2 (enExample) |
| EP (1) | EP3519813B1 (enExample) |
| JP (1) | JP7065862B2 (enExample) |
| CN (1) | CN109791141B (enExample) |
| DK (1) | DK3519813T3 (enExample) |
| ES (1) | ES2881810T3 (enExample) |
| GB (1) | GB201616640D0 (enExample) |
| WO (1) | WO2018060741A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2021015445A (es) * | 2019-06-27 | 2022-04-06 | Binary Llc | Ensayo de quimioluminiscencia a base de oxidasa de leucocitos fagocitica en sangre entera y en fluidos corporales aplicables a las pruebas de diagnostico de punto de cuidado (poc) la medicion de punto de cuidado (poc) de la funcion neutrofila absoluta (anf). |
| WO2022136850A1 (en) * | 2020-12-22 | 2022-06-30 | Seroxo Limited | Method for diagnosing and monitoring sepsis |
| GB2619197A (en) * | 2021-02-02 | 2023-11-29 | Seroxo Ltd | Monitoring COVID-19 progression and treatment |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6159683A (en) | 1997-12-16 | 2000-12-12 | Spectral Diagnostics, Inc. | Method of determining stage of sepsis |
| WO2002099085A2 (en) * | 2001-03-27 | 2002-12-12 | Human Genome Sciences, Inc. | Human secreted proteins |
| GB0225885D0 (en) | 2002-11-06 | 2002-12-11 | Isis Innovation | Quantifying exposure to stress |
| AU2005286663A1 (en) * | 2004-09-23 | 2006-03-30 | Vasgene Therapeutics, Inc. | Compositions and methods for detecting and treating tumors |
| AT504232A1 (de) * | 2006-10-03 | 2008-04-15 | Hans Dr Loibner | Prognostische parameter |
| WO2008074131A1 (en) * | 2006-12-20 | 2008-06-26 | Mcmaster University | Skin and salivary tests for the detection of sensitivity to oxidative stress based therapies |
| CN107085108A (zh) * | 2008-09-05 | 2017-08-22 | A&G药品公司 | 诊断癌症和确定癌症患者的总体生存和无病生存的方法 |
| US9199028B2 (en) * | 2010-01-15 | 2015-12-01 | Memorial Sloan-Kettering Cancer Center | Use of entrained neutrophils to treat metastatic and micrometastatic disease in at risk patients |
| US20140127179A1 (en) * | 2012-11-02 | 2014-05-08 | Scientific Formulations, Llc | Natural Killer Cell Formulations |
-
2016
- 2016-09-30 GB GBGB1616640.7A patent/GB201616640D0/en not_active Ceased
-
2017
- 2017-10-02 ES ES17784992T patent/ES2881810T3/es active Active
- 2017-10-02 EP EP17784992.4A patent/EP3519813B1/en active Active
- 2017-10-02 WO PCT/GB2017/052947 patent/WO2018060741A1/en not_active Ceased
- 2017-10-02 CN CN201780060988.2A patent/CN109791141B/zh active Active
- 2017-10-02 DK DK17784992.4T patent/DK3519813T3/da active
- 2017-10-02 US US16/337,035 patent/US11435341B2/en active Active
- 2017-10-02 JP JP2019538737A patent/JP7065862B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20200033327A1 (en) | 2020-01-30 |
| JP2019529959A (ja) | 2019-10-17 |
| CN109791141B (zh) | 2023-08-15 |
| EP3519813B1 (en) | 2021-06-30 |
| JP7065862B2 (ja) | 2022-05-12 |
| WO2018060741A1 (en) | 2018-04-05 |
| GB201616640D0 (en) | 2016-11-16 |
| US11435341B2 (en) | 2022-09-06 |
| EP3519813A1 (en) | 2019-08-07 |
| CN109791141A (zh) | 2019-05-21 |
| DK3519813T3 (da) | 2021-08-09 |
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