ES287587A1 - A procedure for the synthetic manufacture of 2odeoxi-5-fluoro-pure citidine or its anode alpha pure (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the synthetic manufacture of 2odeoxi-5-fluoro-pure citidine or its anode alpha pure (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES287587A1 ES287587A1 ES287587A ES287587A ES287587A1 ES 287587 A1 ES287587 A1 ES 287587A1 ES 287587 A ES287587 A ES 287587A ES 287587 A ES287587 A ES 287587A ES 287587 A1 ES287587 A1 ES 287587A1
- Authority
- ES
- Spain
- Prior art keywords
- pure
- fluoro
- anomer
- translation
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A process for the synthetic manufacture of pure 2'-deoxy-5-fluoro-cytisine or its pure alpha anomer, respectively, characterized in that it comprises reacting 5-fluoro-cytosine with an acylating agent, reacting the -N-mono-acyl-5-fluoro-cytosine produced with a mercury salt to form the monomercurial salt of said 4-N-mono-acyl-5-fluoro-cytosine, reacting said monomercurial salt with a halide of 3, 5-diaroyl-2-deoxy-D-ribofuranosyl to produce a mixture containing the alpha anomer and the beta anomer of 4-N-mono-acyl-1- (3 ', 5'-di-O-aroyl-2 '-deoxy-D-ribofuranosyl) -5-fluoro-cytosine, separating said beta anomer from said alpha anomer and hydrolyzing said beta anomer and/or said alpha anomer separately by treating them with an alkali. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19143862A | 1962-05-01 | 1962-05-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES287587A1 true ES287587A1 (en) | 1963-11-01 |
Family
ID=22705512
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES287587A Expired ES287587A1 (en) | 1962-05-01 | 1963-04-30 | A procedure for the synthetic manufacture of 2odeoxi-5-fluoro-pure citidine or its anode alpha pure (Machine-translation by Google Translate, not legally binding) |
Country Status (6)
Country | Link |
---|---|
BR (1) | BR6348745D0 (en) |
CH (1) | CH421973A (en) |
DK (1) | DK115916B (en) |
ES (1) | ES287587A1 (en) |
FR (1) | FR1514917A (en) |
GB (3) | GB989456A (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA106889C2 (en) * | 2009-08-07 | 2014-10-27 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | N1-ACYL-5-FLORPYRIMIDINONE DERIVATIVES |
WO2014105844A1 (en) | 2012-12-28 | 2014-07-03 | Dow Agrosciences Llc | N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1 (2h)-carboxylate derivatives |
UA117123C2 (en) | 2012-12-28 | 2018-06-25 | Адама Махтешім Лтд. | 1-(substituted-benzoyl)-5-fluoro-4-imino-3-methyl-3,4-dihydropyrimidin-2(1h)-one derivatives |
KR20150100869A (en) | 2012-12-28 | 2015-09-02 | 다우 아그로사이언시즈 엘엘씨 | N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1 (2h)-carboxamides derivatives |
WO2014105845A1 (en) | 2012-12-31 | 2014-07-03 | Dow Agrosciences Llc | 3-alkyl-5-fluoro-4-substituted-imino-3,4-dihydropyrimidin-2(1h)-one derivatives as fungicides |
-
1963
- 1963-04-19 CH CH500663A patent/CH421973A/en unknown
- 1963-04-29 BR BR14874563A patent/BR6348745D0/en unknown
- 1963-04-30 FR FR933131A patent/FR1514917A/en not_active Expired
- 1963-04-30 ES ES287587A patent/ES287587A1/en not_active Expired
- 1963-05-01 GB GB5220164A patent/GB989456A/en not_active Expired
- 1963-05-01 GB GB1706363A patent/GB989455A/en not_active Expired
- 1963-05-01 GB GB5220264A patent/GB1002278A/en not_active Expired
- 1963-05-01 DK DK206163A patent/DK115916B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CH421973A (en) | 1966-10-15 |
GB989456A (en) | 1965-04-22 |
GB1002278A (en) | 1965-08-25 |
GB989455A (en) | 1965-04-22 |
BR6348745D0 (en) | 1973-07-03 |
FR1514917A (en) | 1968-03-01 |
DK115916B (en) | 1969-11-24 |
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