ES2856063T3 - L-serina para su uso en el tratamiento de trastornos neurodegenerativos - Google Patents

L-serina para su uso en el tratamiento de trastornos neurodegenerativos Download PDF

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Publication number
ES2856063T3
ES2856063T3 ES12851576T ES12851576T ES2856063T3 ES 2856063 T3 ES2856063 T3 ES 2856063T3 ES 12851576 T ES12851576 T ES 12851576T ES 12851576 T ES12851576 T ES 12851576T ES 2856063 T3 ES2856063 T3 ES 2856063T3
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ES
Spain
Prior art keywords
serine
proteins
bmaa
aggregation
misfolding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12851576T
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English (en)
Spanish (es)
Inventor
Kenneth Rodgers
Rachael Dunlop
Paul Cox
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute for EthnoMedicine
Original Assignee
Institute for EthnoMedicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application granted granted Critical
Publication of ES2856063T3 publication Critical patent/ES2856063T3/es
Active legal-status Critical Current
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Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Environmental Sciences (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES12851576T 2011-11-21 2012-11-21 L-serina para su uso en el tratamiento de trastornos neurodegenerativos Active ES2856063T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161562194P 2011-11-21 2011-11-21
PCT/US2012/066373 WO2013078395A1 (en) 2011-11-21 2012-11-21 L-serine compositions, methods and uses for treating neurodegenerative diseases and disorders

Publications (1)

Publication Number Publication Date
ES2856063T3 true ES2856063T3 (es) 2021-09-27

Family

ID=48470319

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12851576T Active ES2856063T3 (es) 2011-11-21 2012-11-21 L-serina para su uso en el tratamiento de trastornos neurodegenerativos

Country Status (10)

Country Link
US (5) US20130156846A1 (https=)
EP (1) EP2782566B1 (https=)
JP (1) JP6265908B2 (https=)
AU (1) AU2012340563B2 (https=)
CA (1) CA2855854C (https=)
DK (1) DK2782566T3 (https=)
ES (1) ES2856063T3 (https=)
IL (1) IL232710B (https=)
PT (1) PT2782566T (https=)
WO (1) WO2013078395A1 (https=)

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MX2017006748A (es) * 2014-11-24 2017-08-28 Entrinsic Health Solutions Inc Composiciones de aminoácidos para el tratamiento de síntomas de enfermedades.
US10960076B2 (en) 2017-01-25 2021-03-30 Church & Dwight Co. Inc. Gummy dosage forms comprising serine
KR20180101242A (ko) 2017-03-02 2018-09-12 주식회사 아스트로젠 엘­세린을 유효성분으로 포함하는 혈뇌장벽 장애의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품
AU2019282362B2 (en) * 2018-06-08 2025-04-03 The Institute For Ethnomedicine Method of enhancing glucose levels in the central nervous system
KR101952443B1 (ko) * 2018-08-23 2019-02-26 주식회사 아스트로젠 신규한 마그네슘­세리네이트 화합물 및 이의 용도
KR102022118B1 (ko) * 2019-01-07 2019-09-18 주식회사 아스트로젠 중추신경계 질환의 예방 또는 치료용 세린 유도체 화합물
AU2020334128B2 (en) * 2019-08-21 2025-10-23 Brain Chemistry Labs Compositions comprising a metal and L-serine, and uses thereof
US12578348B2 (en) * 2021-02-05 2026-03-17 The Institute For Ethnomedicine Blood indicators of Alzheimer's disease
CN112972458B (zh) * 2021-03-05 2022-10-04 北京北科华夏生物医药科技有限公司 一种组合物在制备阿尔兹海默症治疗药物中的应用
KR102522508B1 (ko) * 2022-12-16 2023-04-18 주식회사 아스트로젠 마그네슘-세리네이트의 신규한 결정형 및 이의 제조방법
WO2025014008A1 (ko) * 2023-07-07 2025-01-16 주식회사 아스트로젠 질환의 치료 방법
KR20250081156A (ko) * 2023-11-29 2025-06-05 주식회사 아스트로젠 L-세린 염산염의 제조 방법 및 이의 용도
CN118303636A (zh) * 2024-04-12 2024-07-09 南通大学 一种改善帕金森症状的功能性食品
KR20260010331A (ko) * 2024-07-12 2026-01-20 주식회사 아스트로젠 L-세린의 리포좀 제형 및 이의 제조 방법

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US4491589A (en) * 1982-05-17 1985-01-01 The Trustees Of Columbia University In The City Of New York Amino acid solutions for parenteral nutrition and methods of formulation and use
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
SE8701662L (sv) * 1987-04-22 1988-10-23 Gelder Nico M Van Saett och medel foer att behandla neurologiska sjukdomar, exempelvis migraen genom paaverkan av nervcellerna
JPS6440453A (en) 1987-08-05 1989-02-10 Mitsui Toatsu Chemicals Racemization of optically active serine
US5668117A (en) 1991-02-22 1997-09-16 Shapiro; Howard K. Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments
SE502280C2 (sv) 1991-12-20 1995-09-25 Bio Swede Ab Separering av aminosyror, aminosyrabaserad monomer och förfarande för framställning därav samt polymert material och förfarande för framställning därav
WO1996015788A1 (en) 1994-11-23 1996-05-30 G.D. Searle & Co. Use of amino-isoxazolidone compounds for improvement of implicit memory
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Also Published As

Publication number Publication date
IL232710A0 (en) 2014-07-31
US11700840B2 (en) 2023-07-18
EP2782566A1 (en) 2014-10-01
EP2782566A4 (en) 2016-01-13
DK2782566T3 (da) 2021-02-08
US20140212893A1 (en) 2014-07-31
US20210153483A1 (en) 2021-05-27
US20130156846A1 (en) 2013-06-20
EP2782566B1 (en) 2021-01-06
WO2013078395A1 (en) 2013-05-30
US20220000082A1 (en) 2022-01-06
US20180027781A1 (en) 2018-02-01
CA2855854C (en) 2020-03-31
AU2012340563A1 (en) 2014-05-29
US12295353B2 (en) 2025-05-13
US11974551B2 (en) 2024-05-07
CA2855854A1 (en) 2013-05-30
AU2012340563B2 (en) 2017-01-19
US11917986B2 (en) 2024-03-05
JP2014534263A (ja) 2014-12-18
IL232710B (en) 2021-12-01
PT2782566T (pt) 2021-03-03
JP6265908B2 (ja) 2018-01-24

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