ES2855032T3 - Compuestos de [1,2,4]triazolo[1,5-a]pirimidina como inhibidores de PDE2 - Google Patents
Compuestos de [1,2,4]triazolo[1,5-a]pirimidina como inhibidores de PDE2 Download PDFInfo
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- ES2855032T3 ES2855032T3 ES17797898T ES17797898T ES2855032T3 ES 2855032 T3 ES2855032 T3 ES 2855032T3 ES 17797898 T ES17797898 T ES 17797898T ES 17797898 T ES17797898 T ES 17797898T ES 2855032 T3 ES2855032 T3 ES 2855032T3
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Classifications
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Neurosurgery (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Epidemiology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16196943 | 2016-11-02 | ||
| PCT/EP2017/077920 WO2018083103A1 (en) | 2016-11-02 | 2017-10-31 | [1,2,4]triazolo[1,5-a]pyrimidine compounds as pde2 inhibitors |
Publications (1)
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|---|---|
| ES2855032T3 true ES2855032T3 (es) | 2021-09-23 |
Family
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| ES17797898T Active ES2855032T3 (es) | 2016-11-02 | 2017-10-31 | Compuestos de [1,2,4]triazolo[1,5-a]pirimidina como inhibidores de PDE2 |
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| Country | Link |
|---|---|
| US (1) | US11053248B2 (OSRAM) |
| EP (1) | EP3535269B1 (OSRAM) |
| JP (1) | JP7021208B2 (OSRAM) |
| KR (1) | KR20190071721A (OSRAM) |
| CN (1) | CN109937202B (OSRAM) |
| AU (1) | AU2017353315B2 (OSRAM) |
| BR (1) | BR112019008163A2 (OSRAM) |
| CA (1) | CA3038916A1 (OSRAM) |
| EA (1) | EA039102B1 (OSRAM) |
| ES (1) | ES2855032T3 (OSRAM) |
| MX (1) | MX386174B (OSRAM) |
| WO (1) | WO2018083103A1 (OSRAM) |
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| BR112019008163A2 (pt) | 2016-11-02 | 2019-07-09 | Janssen Pharmaceutica Nv | compostos de [1,2,4]triazolo[1,5-a]pirimidina como inibidores de pde2 |
| SG11201903892UA (en) | 2016-11-02 | 2019-05-30 | Janssen Pharmaceutica Nv | [1,2,4]triazolo[1,5-a]pyrimidine derivatives as pde2 inhibitors |
| ES2912264T3 (es) | 2016-11-02 | 2022-05-25 | Janssen Pharmaceutica Nv | Compuestos de [1,2,4]triazolo[1,5-a]pirimidina como inhibidores de PDE2 |
| EP4028013A4 (en) * | 2019-09-12 | 2023-10-18 | Disarm Therapeutics, Inc. | MRSA1 INHIBITORS |
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| US4036840A (en) * | 1972-06-07 | 1977-07-19 | Icn Pharmaceuticals | 2-Substituted-s-triazolo[1,5a]pyrimidines |
| WO1993000313A2 (en) | 1991-06-27 | 1993-01-07 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
| UA59433C2 (uk) | 1998-01-27 | 2003-09-15 | Авентіс Фармасьютікалс Продактс Інк. | ЗАМІЩЕНІ ОКСОАЗАГЕТЕРОЦИКЛІЧНІ ІНГІБІТОРИ ФАКТОРА Хa ТА ПРОМІЖНІ СПОЛУКИ ДЛЯ ЇХ ОТРИМАННЯ |
| US6194410B1 (en) | 1998-03-11 | 2001-02-27 | Hoffman-La Roche Inc. | Pyrazolopyrimidine and pyrazolines and process for preparation thereof |
| US20040014744A1 (en) | 2002-04-05 | 2004-01-22 | Fortuna Haviv | Substituted pyridines having antiangiogenic activity |
| KR20050047132A (ko) | 2002-10-03 | 2005-05-19 | 버텍스 파마슈티칼스 인코포레이티드 | 신경계 질환 치료용 피페라진 및 피페리딘 유도체 |
| EP1644003A1 (en) | 2003-06-04 | 2006-04-12 | Vernalis (Cambridge) Limited | Triazolo ´1,5-a!pyrimidines and their use in medicine |
| EA011300B1 (ru) | 2003-07-16 | 2009-02-27 | Янссен Фармацевтика Н.В. | Производные триазолопиримидина в качестве ингибиторов киназы гликогенсинтазы-3 |
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| HRP20212035T1 (hr) | 2014-04-23 | 2022-04-01 | Dart Neuroscience Llc | Pripravci koji sadrže supstituirane [1,2,4]triazolo[1,5-a]pirimidin-7-il spojeve kao inhibitore pde2 |
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| WO2016107602A1 (zh) | 2015-01-01 | 2016-07-07 | 成都贝斯凯瑞生物科技有限公司 | 一类取代氮杂环衍生物及其应用 |
| WO2016145614A1 (en) | 2015-03-17 | 2016-09-22 | Merck Sharp & Dohme Corp. | Triazolyl pyrimidinone compounds as pde2 inhibitors |
| WO2017000276A1 (en) | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Bicyclic heterocyclic compounds as pde2 inhibitors |
| WO2017000277A1 (en) | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Substituted triazolo bicycliccompounds as pde2 inhibitors |
| WO2017066705A1 (en) | 2015-10-14 | 2017-04-20 | Aquinnah Pharmaceuticals, Inc. | Compounds, compositions and methods of use against stress granules |
| MX2018005342A (es) | 2015-11-02 | 2018-08-15 | Janseen Pharmaceutica Nv | Compuesto de [1,2,4]triazolo[1,5-a]pirimidin-7-ilo. |
| WO2017157882A1 (en) | 2016-03-14 | 2017-09-21 | Université Catholique de Louvain | Serine biosynthetic pathway inhibitors |
| ES2912264T3 (es) | 2016-11-02 | 2022-05-25 | Janssen Pharmaceutica Nv | Compuestos de [1,2,4]triazolo[1,5-a]pirimidina como inhibidores de PDE2 |
| BR112019008163A2 (pt) | 2016-11-02 | 2019-07-09 | Janssen Pharmaceutica Nv | compostos de [1,2,4]triazolo[1,5-a]pirimidina como inibidores de pde2 |
| SG11201903892UA (en) | 2016-11-02 | 2019-05-30 | Janssen Pharmaceutica Nv | [1,2,4]triazolo[1,5-a]pyrimidine derivatives as pde2 inhibitors |
| CA3044762A1 (en) | 2016-12-16 | 2018-06-21 | Janssen Pharmaceutica Nv | Bicyclic oga inhibitor compounds |
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- 2017-10-31 MX MX2019005115A patent/MX386174B/es unknown
- 2017-10-31 AU AU2017353315A patent/AU2017353315B2/en not_active Ceased
- 2017-10-31 KR KR1020197011777A patent/KR20190071721A/ko not_active Abandoned
- 2017-10-31 CA CA3038916A patent/CA3038916A1/en active Pending
- 2017-10-31 EA EA201990973A patent/EA039102B1/ru unknown
- 2017-10-31 CN CN201780067815.3A patent/CN109937202B/zh not_active Expired - Fee Related
- 2017-10-31 ES ES17797898T patent/ES2855032T3/es active Active
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| US20200048260A1 (en) | 2020-02-13 |
| JP2019532983A (ja) | 2019-11-14 |
| AU2017353315A1 (en) | 2019-05-02 |
| MX386174B (es) | 2025-03-18 |
| JP7021208B2 (ja) | 2022-02-16 |
| EA039102B1 (ru) | 2021-12-03 |
| CN109937202A (zh) | 2019-06-25 |
| US11053248B2 (en) | 2021-07-06 |
| BR112019008163A2 (pt) | 2019-07-09 |
| AU2017353315B2 (en) | 2021-09-16 |
| EP3535269B1 (en) | 2020-12-09 |
| MX2019005115A (es) | 2019-06-20 |
| CN109937202B (zh) | 2022-12-30 |
| EP3535269A1 (en) | 2019-09-11 |
| CA3038916A1 (en) | 2018-05-11 |
| KR20190071721A (ko) | 2019-06-24 |
| EA201990973A1 (ru) | 2019-09-30 |
| WO2018083103A1 (en) | 2018-05-11 |
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