ES2837130R1 - Método y dispositivo para preparar ácido 2-hidroxi-4-metiltiobutírico y productos intermedios del mismo - Google Patents

Método y dispositivo para preparar ácido 2-hidroxi-4-metiltiobutírico y productos intermedios del mismo

Info

Publication number
ES2837130R1
ES2837130R1 ES202190004A ES202190004A ES2837130R1 ES 2837130 R1 ES2837130 R1 ES 2837130R1 ES 202190004 A ES202190004 A ES 202190004A ES 202190004 A ES202190004 A ES 202190004A ES 2837130 R1 ES2837130 R1 ES 2837130R1
Authority
ES
Spain
Prior art keywords
intermediates
hydroxy
preparing
methylthiobutyric acid
methylthiobutyric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES202190004A
Other languages
English (en)
Other versions
ES2837130B2 (es
ES2837130A2 (es
Inventor
Zhirong Chen
Hong Yin
Baishan Hu
Zhengjiang Wang
Zhixuan Wang
Cong Chen
Guisheng Qiu
Qichuan Li
Qingai Shi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shandong Nhu Amino Acid Co Ltd
Zhejiang University ZJU
Zhejiang NHU Co Ltd
Original Assignee
Shandong Nhu Amino Acid Co Ltd
Zhejiang University ZJU
Zhejiang NHU Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shandong Nhu Amino Acid Co Ltd, Zhejiang University ZJU, Zhejiang NHU Co Ltd filed Critical Shandong Nhu Amino Acid Co Ltd
Publication of ES2837130A2 publication Critical patent/ES2837130A2/es
Publication of ES2837130R1 publication Critical patent/ES2837130R1/es
Application granted granted Critical
Publication of ES2837130B2 publication Critical patent/ES2837130B2/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/18—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by addition of thiols to unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/12—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms
    • C07C321/14—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES202190004A 2018-11-01 2019-08-27 Método y dispositivo para preparar ácido 2-hidroxi-4-metiltiobutírico y productos intermedios del mismo Active ES2837130B2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201811296139.XA CN111116437B (zh) 2018-11-01 2018-11-01 制备2-羟基-4-甲硫基丁酸及其中间体的方法和装置
PCT/CN2019/102680 WO2020088060A1 (zh) 2018-11-01 2019-08-27 制备2-羟基-4-甲硫基丁酸及其中间体的方法和装置

Publications (3)

Publication Number Publication Date
ES2837130A2 ES2837130A2 (es) 2021-06-29
ES2837130R1 true ES2837130R1 (es) 2023-02-24
ES2837130B2 ES2837130B2 (es) 2023-12-13

Family

ID=70464706

Family Applications (1)

Application Number Title Priority Date Filing Date
ES202190004A Active ES2837130B2 (es) 2018-11-01 2019-08-27 Método y dispositivo para preparar ácido 2-hidroxi-4-metiltiobutírico y productos intermedios del mismo

Country Status (5)

Country Link
US (1) US11130732B2 (es)
CN (1) CN111116437B (es)
ES (1) ES2837130B2 (es)
MX (1) MX2021002443A (es)
WO (1) WO2020088060A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111393321A (zh) * 2020-05-20 2020-07-10 山东新和成氨基酸有限公司 1-氰基-2-丙烯基乙酸酯的制备方法
CN115650890A (zh) * 2022-04-28 2023-01-31 宁夏紫光天化蛋氨酸有限责任公司 2-羟基-4-甲硫基丁腈的生产尾气处理方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5847207A (en) * 1994-08-12 1998-12-08 Degussa Aktiengesellschaft Process for producing 2-hydroxy-4-methylthiobutyric acid (MHA) and its use as feed stuff supplement
WO2001010776A1 (en) * 1999-08-05 2001-02-15 Novus International, Inc. Reductive combustion of ammonium salts of sulfuric acid
US20120215022A1 (en) * 2011-02-23 2012-08-23 Evonik Degussa Gmbh Method for the production of 2-hydroxy-4-(methylthio)butyronitrile from 3-(methylthio)propanal and hydrogen cyanide
CN103664717A (zh) * 2013-11-19 2014-03-26 重庆紫光化工股份有限公司 廉价的环境友好的d,l-2-羟基-4-甲硫基丁酸的制备方法
WO2017140665A1 (en) * 2016-02-15 2017-08-24 Evonik Degussa Gmbh Method for preparing 3-methylthiopropionaldehyde

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2745745A (en) 1952-10-30 1956-05-15 Monsanto Chemicals Poultry feed
FR2314917A1 (fr) * 1975-06-20 1977-01-14 Rhone Poulenc Ind Procede de fabrication de l'aldehyde beta-methylthiopropionique
FR2590896B1 (fr) 1985-12-03 1988-07-22 Aec Chim Organ Biolog Procede de preparation d'une solution aqueuse d'un sel alcalin de la methionine
ES2005784A6 (es) 1988-02-22 1989-03-16 Desarrollo Tecnico Ind S A Soc Un procedimiento para preparar soluciones acuosas de acido 2-hidroxi-4-metil-tiobutirico.
US5352837A (en) * 1993-06-08 1994-10-04 Novus International, Inc. Process for the preparation of 3-(methylthio)propanal
FR2733231B1 (fr) 1995-04-24 1997-07-04 Rhone Poulenc Nutrition Animal Procede de condensation de l'acide cyanhydrique avec un aldehyde
US5663409A (en) * 1995-06-07 1997-09-02 Novus International, Inc. Process for the preparation of 3-(methylthio) propanal and 2-hydroxy-4-(methylthio) butanenitrile
US5856567A (en) * 1995-06-07 1999-01-05 Novus International, Inc. Continuous hydrolysis process for preparing 2-hydroxy-4-methylthiobutanioc acid or salts thereof
EP1413573A1 (en) 2002-10-24 2004-04-28 Adisseo France S.A.S. Process for the production of 3-methylthiopropanal
DE102004038053A1 (de) 2004-08-05 2006-04-27 Degussa Ag Verfahren zur Herstellung von 3-(Methylthio)propanal
JP2010111642A (ja) 2008-11-07 2010-05-20 Sumitomo Chemical Co Ltd メチオニンの製造方法
DE102010064250A1 (de) * 2010-12-28 2012-06-28 Evonik Degussa Gmbh Verfahren zur Herstellung von Methylmercaptopropionaldehyd
EP2679579A1 (de) * 2012-06-27 2014-01-01 Evonik Industries AG Integriertes Verfahren zur Herstellung von Acrolein und 3-Methylmercaptopropionaldehyd
CN102796030A (zh) * 2012-08-31 2012-11-28 重庆紫光天化蛋氨酸有限责任公司 由甲硫醇和丙烯醛液液反应制备3-甲硫基丙醛的方法及装置
CN103420883A (zh) * 2013-08-28 2013-12-04 重庆紫光化工股份有限公司 利用粗氢氰酸气体制备2-羟基-4-甲硫基丁腈的方法
CN103467348B (zh) * 2013-10-08 2015-09-16 重庆紫光化工股份有限公司 大颗粒晶型高堆积密度2-羟基-4-甲硫基丁酸钙的制备方法
CN104262216A (zh) * 2014-10-15 2015-01-07 重庆紫光化工股份有限公司 一种2-羟基-4-甲硫基丁酸的制备方法
CN105732450A (zh) * 2016-01-22 2016-07-06 曾庆云 3-甲硫基丙醛制备装置及其制备方法
CN107628976B (zh) * 2017-09-27 2019-06-04 山东新和成氨基酸有限公司 一种清洁的连续制备2-羟基-4-甲硫基丁酸的方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5847207A (en) * 1994-08-12 1998-12-08 Degussa Aktiengesellschaft Process for producing 2-hydroxy-4-methylthiobutyric acid (MHA) and its use as feed stuff supplement
WO2001010776A1 (en) * 1999-08-05 2001-02-15 Novus International, Inc. Reductive combustion of ammonium salts of sulfuric acid
US20120215022A1 (en) * 2011-02-23 2012-08-23 Evonik Degussa Gmbh Method for the production of 2-hydroxy-4-(methylthio)butyronitrile from 3-(methylthio)propanal and hydrogen cyanide
CN103664717A (zh) * 2013-11-19 2014-03-26 重庆紫光化工股份有限公司 廉价的环境友好的d,l-2-羟基-4-甲硫基丁酸的制备方法
WO2017140665A1 (en) * 2016-02-15 2017-08-24 Evonik Degussa Gmbh Method for preparing 3-methylthiopropionaldehyde

Also Published As

Publication number Publication date
MX2021002443A (es) 2022-06-14
US11130732B2 (en) 2021-09-28
CN111116437B (zh) 2021-02-05
CN111116437A (zh) 2020-05-08
US20210147350A1 (en) 2021-05-20
ES2837130B2 (es) 2023-12-13
ES2837130A2 (es) 2021-06-29
WO2020088060A1 (zh) 2020-05-07

Similar Documents

Publication Publication Date Title
BR112017003966A2 (pt) aparelhos e métodos para a produção simultânea de compostos canabinoides
BR112017007646A2 (pt) método e aparelho para comunicação heterogênea
BR112016027652A2 (pt) Método para produzir tiametoxam
ES2708149R1 (es) Método y dispositivo para limpieza ultrasónica
CL2017002930S1 (es) Aparato para hornear
ES2837130R1 (es) Método y dispositivo para preparar ácido 2-hidroxi-4-metiltiobutírico y productos intermedios del mismo
BR112016030604A2 (pt) Processo para preparação de ácidos 3- hidroxipicolínicos
BR112016018716A2 (pt) aparelho para medição.
ES2773398R1 (es) Método para mejorar aceites usados
ES2974672T3 (es) Método para cría de cerdos
BR112016000831A2 (pt) método e aparelho para a formação de um pirulito plano
BR112017008394A2 (pt) aparelho e método para dobrar
ITUA20162718A1 (it) Apparato di avvolgimento
ES1207513Y (es) Dispositivo para fumadores
ES1135015Y (es) Dispositivo para extraer mucosidad de las fosas nasales
FI20155243A (fi) Kertakäyttöinen testiliuska
ES1231551Y (es) Dispositivo para clavar alfileres
ES1215939Y (es) Dispositivo elevador para tumbonas
ES1221697Y (es) Dispositivo adaptador para escarpia
IT201900024547A1 (it) Apparato per cromopuntura
ES1224334Y (es) Dispositivo para aplicar soluciones
ES1225069Y (es) Dispositivo para fluidoterapia
ES1224770Y (es) Polvera para productos cosméticos
IT201700119691A1 (it) Apparecchio per aerosol-terapia
ES1202462Y (es) Estructura desmontable para vallados

Legal Events

Date Code Title Description
EC2A Search report published

Ref document number: 2837130

Country of ref document: ES

Kind code of ref document: R1

Effective date: 20230217

FG2A Definitive protection

Ref document number: 2837130

Country of ref document: ES

Kind code of ref document: B2

Effective date: 20231213