ES2834851T3 - Nuevos inhibidores de calicreína 7 - Google Patents
Nuevos inhibidores de calicreína 7 Download PDFInfo
- Publication number
- ES2834851T3 ES2834851T3 ES15740983T ES15740983T ES2834851T3 ES 2834851 T3 ES2834851 T3 ES 2834851T3 ES 15740983 T ES15740983 T ES 15740983T ES 15740983 T ES15740983 T ES 15740983T ES 2834851 T3 ES2834851 T3 ES 2834851T3
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- Prior art keywords
- acetate
- propyl
- phenyl
- ethyl
- aryl
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- C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1430004 | 2014-01-23 | ||
| PCT/SE2015/050060 WO2015112079A1 (en) | 2014-01-23 | 2015-01-22 | New kallikrein 7 inhibitors |
Publications (1)
| Publication Number | Publication Date |
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| ES2834851T3 true ES2834851T3 (es) | 2021-06-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| ES15740983T Active ES2834851T3 (es) | 2014-01-23 | 2015-01-22 | Nuevos inhibidores de calicreína 7 |
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| Country | Link |
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| US (1) | US9744148B2 (OSRAM) |
| EP (1) | EP3097084B1 (OSRAM) |
| JP (2) | JP6552010B2 (OSRAM) |
| CN (1) | CN106132940B (OSRAM) |
| AU (1) | AU2015209759B2 (OSRAM) |
| CA (1) | CA2934024C (OSRAM) |
| CY (1) | CY1123707T1 (OSRAM) |
| DK (1) | DK3097084T3 (OSRAM) |
| ES (1) | ES2834851T3 (OSRAM) |
| HR (1) | HRP20201915T1 (OSRAM) |
| HU (1) | HUE052990T2 (OSRAM) |
| LT (1) | LT3097084T (OSRAM) |
| PL (1) | PL3097084T3 (OSRAM) |
| PT (1) | PT3097084T (OSRAM) |
| RS (1) | RS61142B1 (OSRAM) |
| SI (1) | SI3097084T1 (OSRAM) |
| SM (1) | SMT202000653T1 (OSRAM) |
| WO (1) | WO2015112079A1 (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3097084B1 (en) * | 2014-01-23 | 2020-09-30 | Sixera Pharma AB | New kallikrein 7 inhibitors |
| EP3305781A1 (en) * | 2016-10-07 | 2018-04-11 | Deutsches Krebsforschungszentrum | Chemical substances which inhibit the enzymatic activity of human kallikrein-related peptidase 6 (klk6) |
| US20200040103A1 (en) | 2018-03-14 | 2020-02-06 | Genentech, Inc. | Anti-klk5 antibodies and methods of use |
| GB201809378D0 (en) * | 2018-06-07 | 2018-07-25 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| US12312414B2 (en) | 2019-09-18 | 2025-05-27 | Genentech, Inc. | Anti-KLK7 antibodies, anti-KLK5 antibodies, multispecific anti-KLK5/KLK7 antibodies, and methods of use |
| CN117084936A (zh) * | 2023-09-22 | 2023-11-21 | 南京盛德生物科技研究院有限公司 | 多萜类化合物作为激肽释放酶抑制剂在化妆品中的应用 |
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|---|---|---|---|---|
| FR2514355A1 (fr) * | 1981-10-14 | 1983-04-15 | Fabre Sa Pierre | Derives de biphenyl alcoyl carboxylates, leur procede de preparation et leur utilisation comme medicaments |
| WO2003101941A2 (en) | 2002-05-31 | 2003-12-11 | Genzyme Corporation | Alpha acyloxyacetamides for kallikrein and urokinase inhibition |
| US7872052B2 (en) | 2003-06-06 | 2011-01-18 | Arexis Ab | Use of heterocyclic compounds as SCCE inhibitors |
| CA2670458C (en) * | 2006-11-23 | 2016-01-05 | Vib Vzw | Activators of lateral root formation |
| AR067336A1 (es) | 2007-06-28 | 2009-10-07 | Novartis Ag | Moduladores de calicreina 7 |
| JP5401459B2 (ja) | 2007-08-17 | 2014-01-29 | ノバルティス アーゲー | カリクレイン７を阻害するための環状デプシペプチドの使用 |
| MX2010001849A (es) | 2007-08-17 | 2010-03-10 | Novartis Ag | Depsipeptidos ciclicos. |
| US8143269B2 (en) * | 2008-10-03 | 2012-03-27 | Calcimedica, Inc. | Inhibitors of store operated calcium release |
| EP2545916A1 (en) | 2011-07-15 | 2013-01-16 | Universite Pierre Et Marie Curie - Paris 6 | Use of coumarin derivatives for the preparation of drugs for treating skin diseases |
| EP3097084B1 (en) * | 2014-01-23 | 2020-09-30 | Sixera Pharma AB | New kallikrein 7 inhibitors |
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| Publication number | Publication date |
|---|---|
| JP2019163296A (ja) | 2019-09-26 |
| CY1123707T1 (el) | 2022-03-24 |
| JP6932386B2 (ja) | 2021-09-08 |
| PT3097084T (pt) | 2020-12-09 |
| JP6552010B2 (ja) | 2019-07-31 |
| EP3097084B1 (en) | 2020-09-30 |
| EP3097084A4 (en) | 2017-10-04 |
| US9744148B2 (en) | 2017-08-29 |
| JP2017505299A (ja) | 2017-02-16 |
| RS61142B1 (sr) | 2020-12-31 |
| HUE052990T2 (hu) | 2021-05-28 |
| AU2015209759B2 (en) | 2018-11-29 |
| DK3097084T3 (da) | 2020-12-21 |
| US20170000753A1 (en) | 2017-01-05 |
| PL3097084T3 (pl) | 2021-02-22 |
| WO2015112079A1 (en) | 2015-07-30 |
| SMT202000653T1 (it) | 2021-01-05 |
| CN106132940B (zh) | 2019-04-23 |
| CA2934024C (en) | 2022-08-23 |
| LT3097084T (lt) | 2020-12-28 |
| HRP20201915T1 (hr) | 2021-01-22 |
| EP3097084A1 (en) | 2016-11-30 |
| CN106132940A (zh) | 2016-11-16 |
| AU2015209759A1 (en) | 2016-07-07 |
| SI3097084T1 (sl) | 2021-01-29 |
| CA2934024A1 (en) | 2015-07-30 |
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