CY1123707T1 - Νεοι αναστολεις καλλικρεϊνης 7 - Google Patents
Νεοι αναστολεις καλλικρεϊνης 7Info
- Publication number
- CY1123707T1 CY1123707T1 CY20201101150T CY201101150T CY1123707T1 CY 1123707 T1 CY1123707 T1 CY 1123707T1 CY 20201101150 T CY20201101150 T CY 20201101150T CY 201101150 T CY201101150 T CY 201101150T CY 1123707 T1 CY1123707 T1 CY 1123707T1
- Authority
- CY
- Cyprus
- Prior art keywords
- inhibitors
- klk7
- prevention
- treatment
- kallikrein
- Prior art date
Links
- 101710176222 Kallikrein-7 Proteins 0.000 title abstract 6
- 102100034867 Kallikrein-7 Human genes 0.000 title abstract 6
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 101001091388 Homo sapiens Kallikrein-7 Proteins 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 102000055383 human KLK7 Human genes 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1430004 | 2014-01-23 | ||
| PCT/SE2015/050060 WO2015112079A1 (en) | 2014-01-23 | 2015-01-22 | New kallikrein 7 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1123707T1 true CY1123707T1 (el) | 2022-03-24 |
Family
ID=53681745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20201101150T CY1123707T1 (el) | 2014-01-23 | 2020-12-04 | Νεοι αναστολεις καλλικρεϊνης 7 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9744148B2 (OSRAM) |
| EP (1) | EP3097084B1 (OSRAM) |
| JP (2) | JP6552010B2 (OSRAM) |
| CN (1) | CN106132940B (OSRAM) |
| AU (1) | AU2015209759B2 (OSRAM) |
| CA (1) | CA2934024C (OSRAM) |
| CY (1) | CY1123707T1 (OSRAM) |
| DK (1) | DK3097084T3 (OSRAM) |
| ES (1) | ES2834851T3 (OSRAM) |
| HR (1) | HRP20201915T1 (OSRAM) |
| HU (1) | HUE052990T2 (OSRAM) |
| LT (1) | LT3097084T (OSRAM) |
| PL (1) | PL3097084T3 (OSRAM) |
| PT (1) | PT3097084T (OSRAM) |
| RS (1) | RS61142B1 (OSRAM) |
| SI (1) | SI3097084T1 (OSRAM) |
| SM (1) | SMT202000653T1 (OSRAM) |
| WO (1) | WO2015112079A1 (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3097084B1 (en) * | 2014-01-23 | 2020-09-30 | Sixera Pharma AB | New kallikrein 7 inhibitors |
| EP3305781A1 (en) * | 2016-10-07 | 2018-04-11 | Deutsches Krebsforschungszentrum | Chemical substances which inhibit the enzymatic activity of human kallikrein-related peptidase 6 (klk6) |
| US20200040103A1 (en) | 2018-03-14 | 2020-02-06 | Genentech, Inc. | Anti-klk5 antibodies and methods of use |
| GB201809378D0 (en) * | 2018-06-07 | 2018-07-25 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| US12312414B2 (en) | 2019-09-18 | 2025-05-27 | Genentech, Inc. | Anti-KLK7 antibodies, anti-KLK5 antibodies, multispecific anti-KLK5/KLK7 antibodies, and methods of use |
| CN117084936A (zh) * | 2023-09-22 | 2023-11-21 | 南京盛德生物科技研究院有限公司 | 多萜类化合物作为激肽释放酶抑制剂在化妆品中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2514355A1 (fr) * | 1981-10-14 | 1983-04-15 | Fabre Sa Pierre | Derives de biphenyl alcoyl carboxylates, leur procede de preparation et leur utilisation comme medicaments |
| WO2003101941A2 (en) | 2002-05-31 | 2003-12-11 | Genzyme Corporation | Alpha acyloxyacetamides for kallikrein and urokinase inhibition |
| US7872052B2 (en) | 2003-06-06 | 2011-01-18 | Arexis Ab | Use of heterocyclic compounds as SCCE inhibitors |
| CA2670458C (en) * | 2006-11-23 | 2016-01-05 | Vib Vzw | Activators of lateral root formation |
| AR067336A1 (es) | 2007-06-28 | 2009-10-07 | Novartis Ag | Moduladores de calicreina 7 |
| JP5401459B2 (ja) | 2007-08-17 | 2014-01-29 | ノバルティス アーゲー | カリクレイン７を阻害するための環状デプシペプチドの使用 |
| MX2010001849A (es) | 2007-08-17 | 2010-03-10 | Novartis Ag | Depsipeptidos ciclicos. |
| US8143269B2 (en) * | 2008-10-03 | 2012-03-27 | Calcimedica, Inc. | Inhibitors of store operated calcium release |
| EP2545916A1 (en) | 2011-07-15 | 2013-01-16 | Universite Pierre Et Marie Curie - Paris 6 | Use of coumarin derivatives for the preparation of drugs for treating skin diseases |
| EP3097084B1 (en) * | 2014-01-23 | 2020-09-30 | Sixera Pharma AB | New kallikrein 7 inhibitors |
-
2015
- 2015-01-22 EP EP15740983.0A patent/EP3097084B1/en active Active
- 2015-01-22 WO PCT/SE2015/050060 patent/WO2015112079A1/en not_active Ceased
- 2015-01-22 SM SM20200653T patent/SMT202000653T1/it unknown
- 2015-01-22 CA CA2934024A patent/CA2934024C/en active Active
- 2015-01-22 RS RS20201461A patent/RS61142B1/sr unknown
- 2015-01-22 CN CN201580005402.3A patent/CN106132940B/zh active Active
- 2015-01-22 LT LTEP15740983.0T patent/LT3097084T/lt unknown
- 2015-01-22 JP JP2016544671A patent/JP6552010B2/ja active Active
- 2015-01-22 HR HRP20201915TT patent/HRP20201915T1/hr unknown
- 2015-01-22 PT PT157409830T patent/PT3097084T/pt unknown
- 2015-01-22 AU AU2015209759A patent/AU2015209759B2/en not_active Ceased
- 2015-01-22 US US15/113,658 patent/US9744148B2/en active Active
- 2015-01-22 ES ES15740983T patent/ES2834851T3/es active Active
- 2015-01-22 SI SI201531440T patent/SI3097084T1/sl unknown
- 2015-01-22 DK DK15740983.0T patent/DK3097084T3/da active
- 2015-01-22 HU HUE15740983A patent/HUE052990T2/hu unknown
- 2015-01-22 PL PL15740983.0T patent/PL3097084T3/pl unknown
-
2019
- 2019-05-14 JP JP2019091722A patent/JP6932386B2/ja active Active
-
2020
- 2020-12-04 CY CY20201101150T patent/CY1123707T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019163296A (ja) | 2019-09-26 |
| JP6932386B2 (ja) | 2021-09-08 |
| PT3097084T (pt) | 2020-12-09 |
| ES2834851T3 (es) | 2021-06-18 |
| JP6552010B2 (ja) | 2019-07-31 |
| EP3097084B1 (en) | 2020-09-30 |
| EP3097084A4 (en) | 2017-10-04 |
| US9744148B2 (en) | 2017-08-29 |
| JP2017505299A (ja) | 2017-02-16 |
| RS61142B1 (sr) | 2020-12-31 |
| HUE052990T2 (hu) | 2021-05-28 |
| AU2015209759B2 (en) | 2018-11-29 |
| DK3097084T3 (da) | 2020-12-21 |
| US20170000753A1 (en) | 2017-01-05 |
| PL3097084T3 (pl) | 2021-02-22 |
| WO2015112079A1 (en) | 2015-07-30 |
| SMT202000653T1 (it) | 2021-01-05 |
| CN106132940B (zh) | 2019-04-23 |
| CA2934024C (en) | 2022-08-23 |
| LT3097084T (lt) | 2020-12-28 |
| HRP20201915T1 (hr) | 2021-01-22 |
| EP3097084A1 (en) | 2016-11-30 |
| CN106132940A (zh) | 2016-11-16 |
| AU2015209759A1 (en) | 2016-07-07 |
| SI3097084T1 (sl) | 2021-01-29 |
| CA2934024A1 (en) | 2015-07-30 |
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