ES2821790T8 - Moduladores de la vía de estrés integrada - Google Patents
Moduladores de la vía de estrés integradaInfo
- Publication number
- ES2821790T8 ES2821790T8 ES17724205T ES17724205T ES2821790T8 ES 2821790 T8 ES2821790 T8 ES 2821790T8 ES 17724205 T ES17724205 T ES 17724205T ES 17724205 T ES17724205 T ES 17724205T ES 2821790 T8 ES2821790 T8 ES 2821790T8
- Authority
- ES
- Spain
- Prior art keywords
- pathway modulators
- integrated stress
- stress pathway
- integrated
- modulators
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662332284P | 2016-05-05 | 2016-05-05 | |
PCT/US2017/031352 WO2017193030A1 (en) | 2016-05-05 | 2017-05-05 | Modulators of the integrated stress pathway |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2821790T3 ES2821790T3 (es) | 2021-04-27 |
ES2821790T8 true ES2821790T8 (es) | 2022-01-03 |
Family
ID=58710114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES17724205T Active ES2821790T3 (es) | 2016-05-05 | 2017-05-05 | Moduladores de la vía de estrés integrada |
Country Status (12)
Country | Link |
---|---|
US (2) | US10864196B2 (es) |
EP (2) | EP3452454B1 (es) |
JP (2) | JP6869331B2 (es) |
CN (1) | CN109641853A (es) |
AR (1) | AR108394A1 (es) |
AU (1) | AU2017260363B2 (es) |
CA (1) | CA3023161A1 (es) |
ES (1) | ES2821790T3 (es) |
PT (1) | PT3452454T (es) |
TW (1) | TW201808914A (es) |
UY (1) | UY37231A (es) |
WO (1) | WO2017193030A1 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10357493B2 (en) | 2017-03-10 | 2019-07-23 | Selenity Therapeutics (Bermuda), Ltd. | Metalloenzyme inhibitor compounds |
CN108809583B (zh) | 2017-05-05 | 2024-03-26 | 华为技术有限公司 | 传输信号的方法和装置 |
US11242327B2 (en) * | 2017-05-15 | 2022-02-08 | Recurium Ip Holdings, Llc | Analgesic compounds |
BR112019025883A2 (pt) * | 2017-06-07 | 2020-06-30 | Glaxosmithkline Intellectual Property Development Limited | compostos químicos como inibidores da via de atf4 |
WO2018225093A1 (en) * | 2017-06-07 | 2018-12-13 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds as atf4 pathway inhibitors |
MX2020001352A (es) | 2017-08-09 | 2020-03-20 | Denali Therapeutics Inc | Compuestos, composiciones y metodos. |
EP3704098B1 (en) * | 2017-11-02 | 2024-01-24 | Calico Life Sciences LLC | Modulators of the integrated stress pathway |
JP2021501785A (ja) | 2017-11-02 | 2021-01-21 | カリコ ライフ サイエンシーズ エルエルシー | 統合的ストレス経路の調節剤 |
AU2018360850A1 (en) * | 2017-11-02 | 2020-06-11 | Abbvie Inc. | Modulators of the integrated stress pathway |
KR20200110650A (ko) | 2017-12-13 | 2020-09-24 | 프락시스 바이오테크 엘엘씨 | 통합된 스트레스 반응 경로의 억제제 |
EP3768660A1 (en) * | 2018-03-23 | 2021-01-27 | Denali Therapeutics Inc. | Modulators of eukaryotic initiation factor 2 |
JP2021527044A (ja) | 2018-06-05 | 2021-10-11 | プラクシス バイオテック エルエルシー | 統合的ストレス応答経路の阻害剤 |
JP7273951B2 (ja) | 2018-09-12 | 2023-05-15 | ノバルティス アーゲー | 抗ウイルス性ピリドピラジンジオン化合物 |
TWI832295B (zh) | 2018-10-11 | 2024-02-11 | 美商嘉來克生命科學有限責任公司 | 整合應激路徑之前藥調節劑 |
JP2022520236A (ja) | 2019-02-13 | 2022-03-29 | デナリ セラピューティクス インコーポレイテッド | 化合物、組成物、及び、方法 |
WO2020167994A1 (en) * | 2019-02-13 | 2020-08-20 | Denali Therapeutics Inc. | Compounds, compositions and methods |
BR112021020106A2 (pt) * | 2019-04-23 | 2021-12-07 | Evotec Int Gmbh | Moduladores da via de resposta ao estresse inte-grado |
BR112021020402A2 (pt) | 2019-04-23 | 2021-12-07 | Evotec Int Gmbh | Moduladores da via de resposta ao estresse integrada |
JP2022533023A (ja) | 2019-04-30 | 2022-07-21 | カリコ ライフ サイエンシーズ エルエルシー | 統合的ストレス経路の調節剤としての置換シクロアルキル |
EP3982965A4 (en) | 2019-06-12 | 2023-01-25 | Praxis Biotech LLC | INTEGRATED STRESS RESPONSE PATHWAY MODULATORS |
CN114667285A (zh) | 2019-09-26 | 2022-06-24 | 诺华股份有限公司 | 抗病毒吡唑并吡啶酮化合物 |
KR20220119653A (ko) | 2019-12-20 | 2022-08-30 | 테나야 테라퓨틱스, 인코포레이티드 | 플루오로알킬-옥사디아졸 및 이의 용도 |
MX2022009243A (es) | 2020-01-28 | 2022-08-16 | Evotec Int Gmbh | Moduladores de la via de respuesta integrada al estres. |
MX2022011143A (es) | 2020-03-11 | 2022-10-13 | Evotec Int Gmbh | Moduladores de la via de respuesta integrada al estres. |
CA3195293A1 (en) | 2020-10-22 | 2022-04-28 | Holly Victoria Atton | Modulators of the integrated stress response pathway |
EP4232447A1 (en) | 2020-10-22 | 2023-08-30 | Evotec International GmbH | Modulators of the integrated stress response pathway |
JP2023546224A (ja) | 2020-10-22 | 2023-11-01 | エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 統合ストレス応答経路のモジュレーター |
WO2024109736A1 (zh) * | 2022-11-21 | 2024-05-30 | 深圳众格生物科技有限公司 | 一种化合物、包含其的药物组合物及其合成方法和用途 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US162A (en) | 1837-04-17 | Island | ||
US5212A (en) | 1847-07-31 | Richard m | ||
US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
DE69212850T2 (de) | 1991-01-15 | 1997-03-06 | Alcon Lab Inc | Verwendung von Karrageenan in topischen ophthalmologischen Zusammensetzungen |
CN100471854C (zh) * | 2002-12-20 | 2009-03-25 | 麦克公司 | 用作11-β-羟基类固醇脱氢酶-1抑制剂的三唑衍生物 |
JO2397B1 (en) * | 2002-12-20 | 2007-06-17 | ميرك شارب اند دوم كوربوريشن | Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors |
WO2005066132A1 (en) | 2004-01-07 | 2005-07-21 | Astrazeneca Ab | Therapeutic agents i |
AU2006203918B2 (en) | 2005-01-05 | 2011-05-19 | Abbvie Inc. | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
EP2281813A1 (en) | 2005-08-08 | 2011-02-09 | Pulmagen Therapeutics (Synergy) Limited | Bicyclo[2.2.1]hept-7-ylamine derivatives and their uses |
EP1954287B2 (en) * | 2005-10-31 | 2016-02-24 | Merck Sharp & Dohme Corp. | Cetp inhibitors |
WO2011087758A1 (en) | 2009-12-22 | 2011-07-21 | H. Lundbeck A/S | Adamantyl amide derivatives and uses of same |
TWI538905B (zh) | 2010-12-22 | 2016-06-21 | H 朗德貝克公司 | 雙環[3.2.1]辛基醯胺衍生物及其用途 |
AU2014233520B2 (en) | 2013-03-15 | 2019-02-21 | The Regents Of The University Of California | Modulators of the eIF2alpha pathway |
US20160318856A1 (en) | 2013-09-11 | 2016-11-03 | The Brigham And Women's Hospital, Inc. | Substituted Urea eIF2alpha Kinase Activators |
TWI760344B (zh) * | 2016-06-24 | 2022-04-11 | 美商梅爾莎納醫療公司 | 吡咯並苯並二氮呯類和彼等之共軛物類 |
-
2017
- 2017-05-04 TW TW106114862A patent/TW201808914A/zh unknown
- 2017-05-05 PT PT177242054T patent/PT3452454T/pt unknown
- 2017-05-05 CN CN201780042067.3A patent/CN109641853A/zh active Pending
- 2017-05-05 AU AU2017260363A patent/AU2017260363B2/en not_active Expired - Fee Related
- 2017-05-05 JP JP2019510574A patent/JP6869331B2/ja active Active
- 2017-05-05 UY UY0001037231A patent/UY37231A/es not_active Application Discontinuation
- 2017-05-05 US US16/098,950 patent/US10864196B2/en active Active
- 2017-05-05 AR ARP170101182A patent/AR108394A1/es unknown
- 2017-05-05 EP EP17724205.4A patent/EP3452454B1/en active Active
- 2017-05-05 EP EP20184319.0A patent/EP3778575A1/en not_active Withdrawn
- 2017-05-05 CA CA3023161A patent/CA3023161A1/en not_active Abandoned
- 2017-05-05 WO PCT/US2017/031352 patent/WO2017193030A1/en unknown
- 2017-05-05 ES ES17724205T patent/ES2821790T3/es active Active
-
2020
- 2020-05-28 US US16/885,766 patent/US20210113532A1/en not_active Abandoned
-
2021
- 2021-04-13 JP JP2021067440A patent/JP2021107415A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3778575A1 (en) | 2021-02-17 |
JP2021107415A (ja) | 2021-07-29 |
US20190142806A1 (en) | 2019-05-16 |
JP6869331B2 (ja) | 2021-05-12 |
US10864196B2 (en) | 2020-12-15 |
AU2017260363A1 (en) | 2018-11-15 |
US20210113532A1 (en) | 2021-04-22 |
EP3452454A1 (en) | 2019-03-13 |
AU2017260363B2 (en) | 2021-12-02 |
AR108394A1 (es) | 2018-08-15 |
WO2017193030A1 (en) | 2017-11-09 |
CN109641853A (zh) | 2019-04-16 |
EP3452454B1 (en) | 2020-07-08 |
JP2019515042A (ja) | 2019-06-06 |
ES2821790T3 (es) | 2021-04-27 |
UY37231A (es) | 2017-11-30 |
PT3452454T (pt) | 2020-10-12 |
TW201808914A (zh) | 2018-03-16 |
CA3023161A1 (en) | 2017-11-09 |
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