ES2808664T3 - Unidad de filtración de fluidos biológicos - Google Patents
Unidad de filtración de fluidos biológicos Download PDFInfo
- Publication number
- ES2808664T3 ES2808664T3 ES14784509T ES14784509T ES2808664T3 ES 2808664 T3 ES2808664 T3 ES 2808664T3 ES 14784509 T ES14784509 T ES 14784509T ES 14784509 T ES14784509 T ES 14784509T ES 2808664 T3 ES2808664 T3 ES 2808664T3
- Authority
- ES
- Spain
- Prior art keywords
- filter
- cancer
- collection chamber
- storage unit
- unit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000001914 filtration Methods 0.000 title claims abstract description 81
- 239000013060 biological fluid Substances 0.000 title claims abstract description 48
- 238000003860 storage Methods 0.000 claims abstract description 90
- 239000012620 biological material Substances 0.000 claims abstract description 47
- 239000002699 waste material Substances 0.000 claims abstract description 39
- 230000000717 retained effect Effects 0.000 claims abstract description 13
- 206010028980 Neoplasm Diseases 0.000 claims description 70
- 210000002700 urine Anatomy 0.000 claims description 69
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 66
- 239000000523 sample Substances 0.000 claims description 66
- 238000000034 method Methods 0.000 claims description 63
- 238000004458 analytical method Methods 0.000 claims description 55
- 206010005003 Bladder cancer Diseases 0.000 claims description 47
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 44
- 239000012530 fluid Substances 0.000 claims description 37
- 201000011510 cancer Diseases 0.000 claims description 34
- 239000000463 material Substances 0.000 claims description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 24
- 239000012528 membrane Substances 0.000 claims description 22
- 239000000872 buffer Substances 0.000 claims description 17
- 102000004169 proteins and genes Human genes 0.000 claims description 16
- 238000012360 testing method Methods 0.000 claims description 16
- 201000010099 disease Diseases 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 13
- 239000004417 polycarbonate Substances 0.000 claims description 13
- 229920000515 polycarbonate Polymers 0.000 claims description 13
- 108020004707 nucleic acids Proteins 0.000 claims description 12
- 102000039446 nucleic acids Human genes 0.000 claims description 12
- 150000007523 nucleic acids Chemical class 0.000 claims description 12
- 238000012545 processing Methods 0.000 claims description 12
- 210000004369 blood Anatomy 0.000 claims description 9
- 239000008280 blood Substances 0.000 claims description 9
- 208000035475 disorder Diseases 0.000 claims description 9
- 230000002485 urinary effect Effects 0.000 claims description 9
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 8
- 206010060862 Prostate cancer Diseases 0.000 claims description 7
- 230000006037 cell lysis Effects 0.000 claims description 7
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 6
- 230000008878 coupling Effects 0.000 claims description 6
- 238000010168 coupling process Methods 0.000 claims description 6
- 238000005859 coupling reaction Methods 0.000 claims description 6
- 229920002521 macromolecule Polymers 0.000 claims description 6
- 239000003755 preservative agent Substances 0.000 claims description 6
- 230000002335 preservative effect Effects 0.000 claims description 6
- 206010006187 Breast cancer Diseases 0.000 claims description 5
- 208000026310 Breast neoplasm Diseases 0.000 claims description 5
- 108091005461 Nucleic proteins Proteins 0.000 claims description 5
- 206010038389 Renal cancer Diseases 0.000 claims description 5
- 239000012472 biological sample Substances 0.000 claims description 5
- 230000006835 compression Effects 0.000 claims description 5
- 238000007906 compression Methods 0.000 claims description 5
- 239000000834 fixative Substances 0.000 claims description 5
- 201000010982 kidney cancer Diseases 0.000 claims description 5
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 206010014759 Endometrial neoplasm Diseases 0.000 claims description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 4
- 230000010261 cell growth Effects 0.000 claims description 4
- 239000001963 growth medium Substances 0.000 claims description 4
- 201000005202 lung cancer Diseases 0.000 claims description 4
- 208000020816 lung neoplasm Diseases 0.000 claims description 4
- 230000014759 maintenance of location Effects 0.000 claims description 4
- 238000003825 pressing Methods 0.000 claims description 4
- 206010044412 transitional cell carcinoma Diseases 0.000 claims description 4
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 3
- 206010014733 Endometrial cancer Diseases 0.000 claims description 3
- 238000003780 insertion Methods 0.000 claims description 3
- 230000037431 insertion Effects 0.000 claims description 3
- 210000003205 muscle Anatomy 0.000 claims description 3
- 210000002966 serum Anatomy 0.000 claims description 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 208000023915 Ureteral Neoplasms Diseases 0.000 claims description 2
- 206010046392 Ureteric cancer Diseases 0.000 claims description 2
- 206010046431 Urethral cancer Diseases 0.000 claims description 2
- 206010046458 Urethral neoplasms Diseases 0.000 claims description 2
- 201000009076 bladder urachal carcinoma Diseases 0.000 claims description 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 2
- 201000007270 liver cancer Diseases 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 208000037819 metastatic cancer Diseases 0.000 claims description 2
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 238000005086 pumping Methods 0.000 claims description 2
- 210000002438 upper gastrointestinal tract Anatomy 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 87
- 108020004414 DNA Proteins 0.000 description 73
- 239000000243 solution Substances 0.000 description 38
- 238000001514 detection method Methods 0.000 description 33
- 210000004881 tumor cell Anatomy 0.000 description 27
- 238000003745 diagnosis Methods 0.000 description 20
- 239000011148 porous material Substances 0.000 description 20
- 238000002574 cystoscopy Methods 0.000 description 19
- 108090000623 proteins and genes Proteins 0.000 description 19
- 230000011987 methylation Effects 0.000 description 16
- 238000007069 methylation reaction Methods 0.000 description 16
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 description 15
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 description 15
- 230000035772 mutation Effects 0.000 description 15
- 239000013049 sediment Substances 0.000 description 14
- 230000035945 sensitivity Effects 0.000 description 14
- 238000003556 assay Methods 0.000 description 11
- 230000000295 complement effect Effects 0.000 description 11
- 239000008188 pellet Substances 0.000 description 11
- 230000008901 benefit Effects 0.000 description 10
- 210000004698 lymphocyte Anatomy 0.000 description 10
- 239000003550 marker Substances 0.000 description 10
- 239000002953 phosphate buffered saline Substances 0.000 description 10
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 9
- 108091012583 BCL2 Proteins 0.000 description 8
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 8
- 210000003932 urinary bladder Anatomy 0.000 description 7
- 230000007067 DNA methylation Effects 0.000 description 6
- 239000002250 absorbent Substances 0.000 description 6
- 230000002745 absorbent Effects 0.000 description 6
- 239000000090 biomarker Substances 0.000 description 6
- 230000003993 interaction Effects 0.000 description 6
- 238000012544 monitoring process Methods 0.000 description 6
- 238000004321 preservation Methods 0.000 description 6
- 238000011084 recovery Methods 0.000 description 6
- 102100030751 Eomesodermin homolog Human genes 0.000 description 5
- 102100021090 Homeobox protein Hox-A9 Human genes 0.000 description 5
- 101001064167 Homo sapiens Eomesodermin homolog Proteins 0.000 description 5
- 102100035394 POU domain, class 4, transcription factor 2 Human genes 0.000 description 5
- 108010063400 Transcription Factor Brn-3B Proteins 0.000 description 5
- 238000005119 centrifugation Methods 0.000 description 5
- 210000005266 circulating tumour cell Anatomy 0.000 description 5
- 108010027263 homeobox protein HOXA9 Proteins 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000004393 prognosis Methods 0.000 description 5
- 210000002307 prostate Anatomy 0.000 description 5
- 238000004062 sedimentation Methods 0.000 description 5
- 101100406576 Arabidopsis thaliana ORTH5 gene Proteins 0.000 description 4
- 102100025176 Cyclin-A1 Human genes 0.000 description 4
- 101000934314 Homo sapiens Cyclin-A1 Proteins 0.000 description 4
- 101000740180 Homo sapiens Sal-like protein 3 Proteins 0.000 description 4
- 102100037191 Sal-like protein 3 Human genes 0.000 description 4
- 101100209917 Xenopus laevis vim2 gene Proteins 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- WVYWICLMDOOCFB-UHFFFAOYSA-N 4-methyl-2-pentanol Chemical compound CC(C)CC(C)O WVYWICLMDOOCFB-UHFFFAOYSA-N 0.000 description 3
- 108700028369 Alleles Proteins 0.000 description 3
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 description 3
- 108091008794 FGF receptors Proteins 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 108020005196 Mitochondrial DNA Proteins 0.000 description 3
- 208000008385 Urogenital Neoplasms Diseases 0.000 description 3
- 230000004075 alteration Effects 0.000 description 3
- 230000003321 amplification Effects 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 238000003935 denaturing gradient gel electrophoresis Methods 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 102000052178 fibroblast growth factor receptor activity proteins Human genes 0.000 description 3
- 230000006607 hypermethylation Effects 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 230000008447 perception Effects 0.000 description 3
- 210000005105 peripheral blood lymphocyte Anatomy 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000012175 pyrosequencing Methods 0.000 description 3
- 238000003753 real-time PCR Methods 0.000 description 3
- 102200006655 rs104894230 Human genes 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- 208000009458 Carcinoma in Situ Diseases 0.000 description 2
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 2
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 2
- 102100029974 GTPase HRas Human genes 0.000 description 2
- 101000584633 Homo sapiens GTPase HRas Proteins 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 229920002684 Sepharose Polymers 0.000 description 2
- 102000044209 Tumor Suppressor Genes Human genes 0.000 description 2
- 108700025716 Tumor Suppressor Genes Proteins 0.000 description 2
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 239000012503 blood component Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000000306 component Substances 0.000 description 2
- 230000002380 cytological effect Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000002781 deodorant agent Substances 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 230000037442 genomic alteration Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 208000006750 hematuria Diseases 0.000 description 2
- 201000004933 in situ carcinoma Diseases 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000007373 indentation Methods 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 238000011862 kidney biopsy Methods 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 238000002271 resection Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- RYQOILLJDKPETL-UHFFFAOYSA-N 5-aminolevulinic acid hexyl ester Chemical compound CCCCCCOC(=O)CCC(=O)CN RYQOILLJDKPETL-UHFFFAOYSA-N 0.000 description 1
- 229950000258 5-aminolevulinic acid hexyl ester Drugs 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 102000018755 Calgranulin B Human genes 0.000 description 1
- 108010052495 Calgranulin B Proteins 0.000 description 1
- 108010062540 Chorionic Gonadotropin Proteins 0.000 description 1
- 102000011022 Chorionic Gonadotropin Human genes 0.000 description 1
- 206010008805 Chromosomal abnormalities Diseases 0.000 description 1
- 208000031404 Chromosome Aberrations Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 108091029523 CpG island Proteins 0.000 description 1
- 108091029430 CpG site Proteins 0.000 description 1
- 238000007399 DNA isolation Methods 0.000 description 1
- 102100034001 DNA replication licensing factor MCM5 Human genes 0.000 description 1
- AHCYMLUZIRLXAA-SHYZEUOFSA-N Deoxyuridine 5'-triphosphate Chemical compound O1[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)C[C@@H]1N1C(=O)NC(=O)C=C1 AHCYMLUZIRLXAA-SHYZEUOFSA-N 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 108010067770 Endopeptidase K Proteins 0.000 description 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 description 1
- 102100030943 Glutathione S-transferase P Human genes 0.000 description 1
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
- 102100040896 Growth/differentiation factor 15 Human genes 0.000 description 1
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 description 1
- 101001017545 Homo sapiens DNA replication licensing factor MCM5 Proteins 0.000 description 1
- 101001010139 Homo sapiens Glutathione S-transferase P Proteins 0.000 description 1
- 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 description 1
- 101000605639 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proteins 0.000 description 1
- 101000637835 Homo sapiens Serum amyloid A-4 protein Proteins 0.000 description 1
- 101000803403 Homo sapiens Vimentin Proteins 0.000 description 1
- 101000964613 Homo sapiens Zinc finger protein 154 Proteins 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 208000002231 Muscle Neoplasms Diseases 0.000 description 1
- 101710138657 Neurotoxin Proteins 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 102100036961 Nuclear mitotic apparatus protein 1 Human genes 0.000 description 1
- 102000004264 Osteopontin Human genes 0.000 description 1
- 108010081689 Osteopontin Proteins 0.000 description 1
- 238000010222 PCR analysis Methods 0.000 description 1
- 238000002944 PCR assay Methods 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 102100038332 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Human genes 0.000 description 1
- 208000002151 Pleural effusion Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 206010037596 Pyelonephritis Diseases 0.000 description 1
- 101150040459 RAS gene Proteins 0.000 description 1
- 101150076031 RAS1 gene Proteins 0.000 description 1
- 239000012083 RIPA buffer Substances 0.000 description 1
- 102000005881 S100 Calcium Binding Protein A6 Human genes 0.000 description 1
- 108010005260 S100 Calcium Binding Protein A6 Proteins 0.000 description 1
- 102100032016 Serum amyloid A-4 protein Human genes 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- 102000005406 Tissue Inhibitor of Metalloproteinase-3 Human genes 0.000 description 1
- 108010031429 Tissue Inhibitor of Metalloproteinase-3 Proteins 0.000 description 1
- 102000006280 Twist-Related Protein 1 Human genes 0.000 description 1
- 108010083162 Twist-Related Protein 1 Proteins 0.000 description 1
- 208000006593 Urologic Neoplasms Diseases 0.000 description 1
- 102100035071 Vimentin Human genes 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 102100040784 Zinc finger protein 154 Human genes 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012501 chromatography medium Substances 0.000 description 1
- 108091092240 circulating cell-free DNA Proteins 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 201000003146 cystitis Diseases 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 230000001877 deodorizing effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000012631 diagnostic technique Methods 0.000 description 1
- 238000007847 digital PCR Methods 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 208000037765 diseases and disorders Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012149 elution buffer Substances 0.000 description 1
- 210000003979 eosinophil Anatomy 0.000 description 1
- 230000001973 epigenetic effect Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000011536 extraction buffer Substances 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 208000022182 gross hematuria Diseases 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 201000010536 head and neck cancer Diseases 0.000 description 1
- 108010036050 human cationic antimicrobial protein 57 Proteins 0.000 description 1
- 229940084986 human chorionic gonadotropin Drugs 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000002390 hyperplastic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000012139 lysis buffer Substances 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 238000003032 molecular docking Methods 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 239000002581 neurotoxin Substances 0.000 description 1
- 231100000618 neurotoxin Toxicity 0.000 description 1
- 238000007481 next generation sequencing Methods 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 108010036112 nuclear matrix protein 22 Proteins 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 229920000052 poly(p-xylylene) Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 238000010837 poor prognosis Methods 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 102000016914 ras Proteins Human genes 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000012764 semi-quantitative analysis Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 239000000107 tumor biomarker Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 201000000334 ureter transitional cell carcinoma Diseases 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 108010064245 urinary gonadotropin fragment Proteins 0.000 description 1
- 208000014001 urinary system disease Diseases 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 208000023747 urothelial carcinoma Diseases 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B10/007—Devices for taking samples of body liquids for taking urine samples
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/0096—Casings for storing test samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D27/00—Cartridge filters of the throw-away type
- B01D27/08—Construction of the casing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1017—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by filtration, e.g. using filters, frits, membranes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/087—Multiple sequential chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
- G01N2001/4088—Concentrating samples by other techniques involving separation of suspended solids filtration
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Clinical Laboratory Science (AREA)
- Plant Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Sampling And Sample Adjustment (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201316347A GB201316347D0 (en) | 2013-09-13 | 2013-09-13 | Biological fluid filtration assembly |
| PCT/GB2014/052776 WO2015036781A1 (en) | 2013-09-13 | 2014-09-12 | Biological fluid filtration assembly |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2808664T3 true ES2808664T3 (es) | 2021-03-01 |
Family
ID=49552641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14784509T Active ES2808664T3 (es) | 2013-09-13 | 2014-09-12 | Unidad de filtración de fluidos biológicos |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20160223442A1 (enExample) |
| EP (1) | EP3043718B1 (enExample) |
| JP (1) | JP6552504B2 (enExample) |
| CN (1) | CN105722466B (enExample) |
| AU (1) | AU2014320077B2 (enExample) |
| CA (1) | CA2924086C (enExample) |
| DK (1) | DK3043718T3 (enExample) |
| ES (1) | ES2808664T3 (enExample) |
| GB (1) | GB201316347D0 (enExample) |
| PL (1) | PL3043718T3 (enExample) |
| WO (1) | WO2015036781A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10533932B2 (en) | 2013-09-13 | 2020-01-14 | Cancer Research Technology Limited | Apparatus and methods for liquid separation and capture of biologics |
| ES2806498T3 (es) * | 2015-06-08 | 2021-02-17 | Arquer Diagnostics Ltd | Métodos para el análisis de una muestra de orina |
| WO2016205233A2 (en) | 2015-06-15 | 2016-12-22 | Cepheid | Integrated purification and measurement of dna methylation and co-measurement of mutations and/or mrna expression levels in an automated reaction cartridge |
| WO2017154349A1 (ja) * | 2016-03-10 | 2017-09-14 | パナソニックＩｐマネジメント株式会社 | 核酸抽出装置、核酸抽出ユニット及び核酸抽出方法 |
| US10585101B2 (en) * | 2016-03-10 | 2020-03-10 | Wavesense, Inc. | Prostatic liquid biopsy for the detection of prostate cancer and benign prostatic hyperplasia |
| JP7082453B2 (ja) * | 2016-07-21 | 2022-06-08 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | 高体積分率粒子精密濾過のための外壁集束のための装置及びその製造方法 |
| JP7123050B2 (ja) * | 2016-12-12 | 2022-08-22 | セファイド | 自動反応カートリッジにおける統合された、ＤＮＡメチル化の精製及び測定並びに変異及び／又はｍＲＮＡ発現レベルの同時測定 |
| WO2018129056A1 (en) | 2017-01-04 | 2018-07-12 | The Research Foundation For The State University Of New York | Biomarker detection device |
| WO2018226097A1 (en) * | 2017-06-08 | 2018-12-13 | Rijksuniversiteit Gronigen | Sensor cartridge for chemical assays of a liquid sample containing analyte moleculess |
| WO2019005827A1 (en) * | 2017-06-30 | 2019-01-03 | Boston Scientific Scimed, Inc. | FILTRATION DEVICE WITH REMOVABLE PROTECTION ELEMENT |
| WO2019043656A1 (en) * | 2017-09-01 | 2019-03-07 | Genus Plc | METHODS AND SYSTEMS FOR ASSESSING AND / OR QUANTIFYING POPULATIONS OF SPERMATOZOIDS WITH SEXUAL ASYMMETRY |
| KR20210006337A (ko) | 2018-03-15 | 2021-01-18 | 크립토스 바이오테크놀로지스, 인코포레이티드 | 열 보조 생화학 반응을 수행하기 위한 방법 및 시스템 |
| IT201800004625A1 (it) * | 2018-04-17 | 2019-10-17 | Dispositivo per la separazione di un campione biologico | |
| KR102117656B1 (ko) * | 2018-06-18 | 2020-06-02 | 한국원자력연구원 | 플란쳇 타입 샘플 제작 장치 |
| CN111467853B (zh) * | 2019-01-23 | 2022-08-02 | 杭州科百特过滤器材有限公司 | 一种用于固定过滤单元的夹具及其操作方法 |
| WO2020172712A1 (en) * | 2019-02-27 | 2020-09-03 | Epiaxis Therapeutics Pty Ltd | Methods and agents for assessing t-cell function and predicting response to therapy |
| CN111855333B (zh) * | 2019-04-24 | 2023-10-03 | 青岛言鼎生物医疗科技有限公司 | 体液中有核细胞吸印富集与吸印染色一体化反应装置及方法 |
| CN109991170A (zh) * | 2019-04-25 | 2019-07-09 | 泗洪县正心医疗技术有限公司 | 一种大样本尿沉渣滤出观察系统 |
| EP3733869A1 (en) * | 2019-05-02 | 2020-11-04 | QIAGEN GmbH | Automated method and system for split pool based barcoding of cellular molecules |
| CN110411787B (zh) * | 2019-06-28 | 2021-10-12 | 李美琴 | 一种用于检验科尿液样品的收集处理装置 |
| CN112362426B (zh) * | 2020-10-30 | 2023-07-21 | 南京华银医学检验所有限公司 | 一种病理检查淋巴结分离装置 |
| WO2023017251A1 (en) | 2021-08-09 | 2023-02-16 | Encelo Laboratories Limited | Primary cell extraction and preservation from fluids |
| WO2023247543A1 (en) * | 2022-06-20 | 2023-12-28 | Testmate Health Sa | Urine, saliva, and/or mouthwash sample preparation system |
| WO2023250074A1 (en) * | 2022-06-23 | 2023-12-28 | Predicine, Inc. | Devices and methods for sample collection |
| CN115855580B (zh) * | 2022-12-01 | 2024-04-19 | 嵩明珍茗食品有限公司 | 一种水体环境取样检测系统 |
| WO2024151767A2 (en) * | 2023-01-12 | 2024-07-18 | Health Science Funding, LLC | Solid tumor therapy |
| DE102023102184A1 (de) * | 2023-01-30 | 2024-08-01 | The smart period blood GmbH | Adapter zum Überführen und Aufbereiten einer Menstruationsausscheidungen enthaltenden Probe in ein verschließbares Probengefäß |
| CN115919375B (zh) * | 2023-03-15 | 2023-05-12 | 潍坊医学院附属医院 | 一种手术后用的唾液收集装置 |
| WO2025248141A1 (en) * | 2024-05-31 | 2025-12-04 | Stratifyer Molecular Pathology Gmbh | Method of detecting urinary tract cancer in a urine sample |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3788484A (en) * | 1971-08-23 | 1974-01-29 | Coulter Electronics | Inline fluid filter |
| BE878481A (fr) * | 1978-09-09 | 1979-12-17 | Bullock George P | Filtres demontables perfectionnes pour canalisations de liquides |
| US4829005A (en) * | 1984-06-15 | 1989-05-09 | Friedman Michael P | Sedimentation filtration microorganism growth culture system |
| US5429803A (en) * | 1991-04-18 | 1995-07-04 | Lamina, Inc. | Liquid specimen container and attachable testing modules |
| US5846487A (en) * | 1996-11-26 | 1998-12-08 | Bennett, Ii; Edward R. | Specimen cartridge |
| JP2002273113A (ja) * | 2001-03-15 | 2002-09-24 | Koganei Corp | 濾過器および薬液供給装置並びに薬液供給方法 |
| US7378054B2 (en) * | 2004-04-16 | 2008-05-27 | Savvipharm Inc | Specimen collecting, processing and analytical assembly |
| EP2024742B1 (en) * | 2006-05-22 | 2020-03-04 | 3M Innovative Properties Company | System and method for preparing samples |
| US20100297691A1 (en) * | 2007-05-31 | 2010-11-25 | Ribeiro Alice Maria M | Devices and processes for collecting and concentrating samples for microbiological analysis |
| FR2934049B1 (fr) * | 2008-07-16 | 2010-10-15 | Millipore Corp | Unite et procede de preparation d'un echantillon pour l'analyse microbiologique d'un liquide. |
| WO2010131140A1 (en) * | 2009-05-09 | 2010-11-18 | Diagcor Bioscience Incorporation Limited | Biological sample collection device |
| JP5800797B2 (ja) * | 2010-03-11 | 2015-10-28 | 株式会社カネカ | 細胞濃縮・回収方法及び細胞回収液 |
| US10166009B2 (en) * | 2012-11-20 | 2019-01-01 | The Trustees Of Columbia University In The City Of New York | Medical apparatus and method for collecting biological samples |
-
2013
- 2013-09-13 GB GB201316347A patent/GB201316347D0/en not_active Ceased
-
2014
- 2014-09-12 CN CN201480062490.6A patent/CN105722466B/zh active Active
- 2014-09-12 WO PCT/GB2014/052776 patent/WO2015036781A1/en not_active Ceased
- 2014-09-12 DK DK14784509.3T patent/DK3043718T3/da active
- 2014-09-12 JP JP2016542375A patent/JP6552504B2/ja active Active
- 2014-09-12 ES ES14784509T patent/ES2808664T3/es active Active
- 2014-09-12 CA CA2924086A patent/CA2924086C/en active Active
- 2014-09-12 US US15/021,470 patent/US20160223442A1/en not_active Abandoned
- 2014-09-12 AU AU2014320077A patent/AU2014320077B2/en active Active
- 2014-09-12 EP EP14784509.3A patent/EP3043718B1/en active Active
- 2014-09-12 PL PL14784509T patent/PL3043718T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB201316347D0 (en) | 2013-10-30 |
| AU2014320077A1 (en) | 2016-04-21 |
| WO2015036781A1 (en) | 2015-03-19 |
| CN105722466A (zh) | 2016-06-29 |
| EP3043718A1 (en) | 2016-07-20 |
| PL3043718T3 (pl) | 2020-12-14 |
| DK3043718T3 (da) | 2020-08-10 |
| JP2016534363A (ja) | 2016-11-04 |
| CA2924086A1 (en) | 2015-03-19 |
| AU2014320077B2 (en) | 2019-01-17 |
| JP6552504B2 (ja) | 2019-07-31 |
| US20160223442A1 (en) | 2016-08-04 |
| CN105722466B (zh) | 2019-03-19 |
| EP3043718B1 (en) | 2020-06-17 |
| CA2924086C (en) | 2023-09-12 |
| NZ718485A (en) | 2020-10-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2808664T3 (es) | Unidad de filtración de fluidos biológicos | |
| US10533932B2 (en) | Apparatus and methods for liquid separation and capture of biologics | |
| ES2604456T3 (es) | Dispositivo para el muestreo de células colorrectales | |
| JP2019501651A (ja) | 腫瘍分子の検出／診断試薬 | |
| EP2705363B1 (en) | Device and method for non-invasive collection of colorectal mucocellular layer and disease detection | |
| JP2012501693A (ja) | 試料材料の濃縮用の生検器具 | |
| US9339259B2 (en) | Colorectal cell sampling device | |
| JP2010008106A (ja) | 糞便処理容器及び糞便処理方法 | |
| CN103543103B (zh) | 一种便携式生化样品定量检测装置 | |
| JP4134047B2 (ja) | 大腸癌マーカー検出方法 | |
| Zuo et al. | Extraosseous (extramedullary) plasmacytomas: a clinicopathologic and immunophenotypic study of 32 Chinese cases | |
| JP2009115658A (ja) | 糞便試料の調製方法、その調製方法を用いた核酸又はタンパク質の抽出方法、その抽出方法を用いた核酸又はタンパク質の検出方法、その検出方法における糞便試料を用いたがん又は感染症の検出方法、並びに、糞便試料の調製容器 | |
| NZ718485B2 (en) | Biological fluid filtration assembly | |
| CN112313345B (zh) | 一种通过活检细胞样本诊断癌症的方法 | |
| Verine | Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity | |
| CN111690746A (zh) | 与肺癌相关的血小板rna标志物及其应用 | |
| CN101519686B (zh) | 用于胃癌和胃癌组织转移的分子检测方法和试剂盒 | |
| US20100092962A1 (en) | Method of Detecting Colorectal Cancer | |
| US20050026230A1 (en) | Method and apparatus for cell recovery | |
| Kholová | Not Enough Cells: How Insufficient Cytological Specimens Are Mirrored by Reporting Systems–Journey from the Bethesda to the WHO Reporting Systems | |
| CN115094140B (zh) | LncRNA AC026412.3作为肝癌诊断和/或预后标志物的应用 | |
| CN103243113A (zh) | Dna分子、扩增该dna分子的引物组、包含该引物组的试剂盒及其使用方法 | |
| Thomas et al. | Early detection of precancerous and cancerous lesions: an overview | |
| Birnboim | DNA yield with an Oragene® self-collection kit | |
| JEON et al. | Evaluation of sensitivity and specificity of MAGE A1-6 RT-nested PCR as a cancer detection method |