ES2796743T3 - Un polipéptido de receptor de factor de crecimiento de fibroblastos 3 (FGR3) soluble para su uso en la prevención o tratamiento de trastornos de retraso del crecimiento esquelético - Google Patents

Un polipéptido de receptor de factor de crecimiento de fibroblastos 3 (FGR3) soluble para su uso en la prevención o tratamiento de trastornos de retraso del crecimiento esquelético Download PDF

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Publication number
ES2796743T3
ES2796743T3 ES14702206T ES14702206T ES2796743T3 ES 2796743 T3 ES2796743 T3 ES 2796743T3 ES 14702206 T ES14702206 T ES 14702206T ES 14702206 T ES14702206 T ES 14702206T ES 2796743 T3 ES2796743 T3 ES 2796743T3
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Prior art keywords
fgfr3
polypeptide
sfgfr3
isolated
mice
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ES14702206T
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English (en)
Spanish (es)
Inventor
Elvire Gouze
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Universite de Toulouse
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Universite Toulouse III Paul Sabatier
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10Protein-tyrosine kinases (2.7.10)
    • C12Y207/10001Receptor protein-tyrosine kinase (2.7.10.1)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES14702206T 2013-01-16 2014-01-16 Un polipéptido de receptor de factor de crecimiento de fibroblastos 3 (FGR3) soluble para su uso en la prevención o tratamiento de trastornos de retraso del crecimiento esquelético Active ES2796743T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IB2013/001480 WO2014111744A1 (en) 2013-01-16 2013-01-16 A soluble fibroblast growth factor receptor 3 (fgr3) polypeptide for use in the prevention or treatment of skeletal growth retardation disorders
PCT/EP2014/050800 WO2014111467A1 (en) 2013-01-16 2014-01-16 A soluble fibroblast growth factor receptor 3 (fgr3) polypeptide for use in the prevention or treatment of skeletal growth retardation disorders

Publications (1)

Publication Number Publication Date
ES2796743T3 true ES2796743T3 (es) 2020-11-30

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ES14702206T Active ES2796743T3 (es) 2013-01-16 2014-01-16 Un polipéptido de receptor de factor de crecimiento de fibroblastos 3 (FGR3) soluble para su uso en la prevención o tratamiento de trastornos de retraso del crecimiento esquelético

Country Status (19)

Country Link
US (5) US20150344855A1 (enExample)
EP (2) EP2945967B1 (enExample)
JP (3) JP2016506914A (enExample)
KR (3) KR20160002681A (enExample)
CN (1) CN105121464B (enExample)
AU (2) AU2013373679A1 (enExample)
CA (2) CA2898415A1 (enExample)
DK (1) DK2945967T3 (enExample)
EA (2) EA201591324A1 (enExample)
ES (1) ES2796743T3 (enExample)
HU (1) HUE049556T2 (enExample)
IL (2) IL239810A0 (enExample)
MX (2) MX372787B (enExample)
PE (1) PE20151664A1 (enExample)
PL (1) PL2945967T3 (enExample)
PT (1) PT2945967T (enExample)
SG (2) SG11201505488XA (enExample)
SI (1) SI2945967T1 (enExample)
WO (2) WO2014111744A1 (enExample)

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AU2013373679A1 (en) 2013-01-16 2015-08-13 Inserm (Institut National De La Sante Et De La Recherche Medicale) A soluble fibroblast growth factor receptor 3 (FGR3) polypeptide for use in the prevention or treatment of skeletal growth retardation disorders
PT3242888T (pt) * 2015-01-07 2020-12-28 Pfizer Armadilhas de fgfr3 solúveis para o tratamento de distúrbios do crescimento ósseo
KR101981774B1 (ko) * 2016-04-25 2019-05-27 장부다 Vr 공간에서 사용자 인터페이스를 제공하는 방법, 디바이스 및 기록매체
HUE058734T2 (hu) * 2016-07-07 2022-09-28 Pfizer Szolúbilis 3-as fibroblaszt növekedési faktor receptor (sFGFR3) polipeptidek és alkalmazásaik
BR112020005459A2 (pt) * 2017-09-20 2020-09-29 Pfizer Inc. tratamento de deposição de gordura visceral anormal usando polipeptídeos de receptor 3 de fator de crescimento de fibroblasto solúvel (sfgfr3)
CN108410803B (zh) * 2018-03-28 2019-02-05 湖南源品细胞生物科技有限公司 一种诱导脂肪干细胞成软骨分化的培养方法和培养液
CN110272900B (zh) * 2019-04-19 2024-03-26 中国人民解放军陆军军医大学 用于制备骨骼发育异常猪模型的sgRNA及其应用
WO2022106976A1 (en) 2020-11-18 2022-05-27 Pfizer Inc. Stable pharmaceutical formulations of soluble fgfr3 decoys
WO2022254319A1 (en) 2021-06-01 2022-12-08 Pfizer Inc. Cell culture method for producing sfgfr3 polypeptide

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PT3242888T (pt) 2015-01-07 2020-12-28 Pfizer Armadilhas de fgfr3 solúveis para o tratamento de distúrbios do crescimento ósseo
HUE058734T2 (hu) 2016-07-07 2022-09-28 Pfizer Szolúbilis 3-as fibroblaszt növekedési faktor receptor (sFGFR3) polipeptidek és alkalmazásaik
BR112020005459A2 (pt) 2017-09-20 2020-09-29 Pfizer Inc. tratamento de deposição de gordura visceral anormal usando polipeptídeos de receptor 3 de fator de crescimento de fibroblasto solúvel (sfgfr3)

Also Published As

Publication number Publication date
AU2013373679A1 (en) 2015-08-13
SG11201505140XA (en) 2015-07-30
JP6995069B2 (ja) 2022-02-04
MX2019013857A (es) 2020-01-20
US10724014B2 (en) 2020-07-28
EA201591055A1 (ru) 2016-04-29
MX2015009142A (es) 2015-11-06
CN105121464B (zh) 2021-05-07
US20200199545A1 (en) 2020-06-25
PE20151664A1 (es) 2015-11-28
US20210032608A1 (en) 2021-02-04
SI2945967T1 (sl) 2020-10-30
US11702642B2 (en) 2023-07-18
CN105121464A (zh) 2015-12-02
CA2898415A1 (en) 2014-07-24
US11814654B2 (en) 2023-11-14
DK2945967T3 (da) 2020-07-13
PL2945967T3 (pl) 2020-11-16
KR20210054026A (ko) 2021-05-12
EP2945967B1 (en) 2020-04-15
SG11201505488XA (en) 2015-08-28
KR20150122136A (ko) 2015-10-30
EP2945967A1 (en) 2015-11-25
KR102249454B1 (ko) 2021-05-07
WO2014111467A1 (en) 2014-07-24
MX372787B (es) 2020-07-03
US20150353624A1 (en) 2015-12-10
PT2945967T (pt) 2020-05-28
JP2016506912A (ja) 2016-03-07
IL239810A0 (en) 2015-08-31
EP3736285A1 (en) 2020-11-11
EA201591324A1 (ru) 2016-01-29
JP2019107006A (ja) 2019-07-04
CA2896978A1 (en) 2014-07-24
KR20160002681A (ko) 2016-01-08
AU2014206844A1 (en) 2015-07-16
IL239996A0 (en) 2015-08-31
JP2016506914A (ja) 2016-03-07
HK1217959A1 (zh) 2017-01-27
US20150344855A1 (en) 2015-12-03
WO2014111744A1 (en) 2014-07-24
US20210032607A1 (en) 2021-02-04
HUE049556T2 (hu) 2020-09-28

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