ES2772701T3 - Uso de nucleosomas libres de células como biomarcadores en muestras de esputo - Google Patents

Uso de nucleosomas libres de células como biomarcadores en muestras de esputo Download PDF

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Publication number
ES2772701T3
ES2772701T3 ES16736594T ES16736594T ES2772701T3 ES 2772701 T3 ES2772701 T3 ES 2772701T3 ES 16736594 T ES16736594 T ES 16736594T ES 16736594 T ES16736594 T ES 16736594T ES 2772701 T3 ES2772701 T3 ES 2772701T3
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ES
Spain
Prior art keywords
cell
epigenetic
free
nucleosome
nucleosomes
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Active
Application number
ES16736594T
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English (en)
Spanish (es)
Inventor
Jacob Micallef
Marielle Herzog
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Belgian Volition SPRL
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Belgian Volition SPRL
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Publication of ES2772701T3 publication Critical patent/ES2772701T3/es
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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875Nucleoproteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/12Pulmonary diseases
    • G01N2800/122Chronic or obstructive airway disorders, e.g. asthma COPD
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES16736594T 2015-07-01 2016-07-01 Uso de nucleosomas libres de células como biomarcadores en muestras de esputo Active ES2772701T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1511512.4A GB201511512D0 (en) 2015-07-01 2015-07-01 Use of cell-free nucleosomes as biomarkers
PCT/GB2016/051994 WO2017001863A1 (en) 2015-07-01 2016-07-01 Use of cell-free nucleosomes as biomarkers in sputum samples

Publications (1)

Publication Number Publication Date
ES2772701T3 true ES2772701T3 (es) 2020-07-08

Family

ID=53872486

Family Applications (1)

Application Number Title Priority Date Filing Date
ES16736594T Active ES2772701T3 (es) 2015-07-01 2016-07-01 Uso de nucleosomas libres de células como biomarcadores en muestras de esputo

Country Status (8)

Country Link
US (1) US20180306804A1 (ru)
EP (1) EP3317671B1 (ru)
JP (1) JP7094700B2 (ru)
CN (1) CN108450000A (ru)
ES (1) ES2772701T3 (ru)
GB (1) GB201511512D0 (ru)
HK (1) HK1255151A1 (ru)
WO (1) WO2017001863A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111918971A (zh) * 2018-03-01 2020-11-10 埃皮塞弗公司 利用化学确定的重组核小体定量核小体修饰
US11154240B2 (en) 2019-04-02 2021-10-26 Kpn Innovations Llc Methods and systems for utilizing diagnostics for informed vibrant constitutional guidance
JP2023503379A (ja) * 2019-12-02 2023-01-27 ベルジアン ボリション エスアールエル バイオマーカーとしての細胞外遊離ヌクレオソームの使用
US11289206B2 (en) 2020-06-02 2022-03-29 Kpn Innovations, Llc. Artificial intelligence methods and systems for constitutional analysis using objective functions
US11211158B1 (en) 2020-08-31 2021-12-28 Kpn Innovations, Llc. System and method for representing an arranged list of provider aliment possibilities

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7229772B1 (en) * 1998-03-18 2007-06-12 Roche Diagnostics Gmbh Detection of apoptotic products
GB201012662D0 (en) * 2010-07-28 2010-09-15 Valirx Plc Method for detecting the presence of a gynaecological growth
GB201115095D0 (en) * 2011-09-01 2011-10-19 Singapore Volition Pte Ltd Method for detecting nucleosomes containing nucleotides
GB201115098D0 (en) * 2011-09-01 2011-10-19 Belgian Volition Sa Method for detecting nucleosomes containing histone variants
SG11201402982TA (en) * 2011-12-07 2014-07-30 Singapore Volition Pte Ltd Method for detecting nucleosome adducts
GB201303575D0 (en) * 2013-02-28 2013-04-10 Singapore Volition Pte Ltd Method for detecting histone modifications in nucleosomes
WO2015048535A1 (en) * 2013-09-27 2015-04-02 Natera, Inc. Prenatal diagnostic resting standards

Also Published As

Publication number Publication date
EP3317671A1 (en) 2018-05-09
US20180306804A1 (en) 2018-10-25
CN108450000A (zh) 2018-08-24
WO2017001863A1 (en) 2017-01-05
EP3317671B1 (en) 2019-11-13
HK1255151A1 (zh) 2019-08-09
GB201511512D0 (en) 2015-08-12
JP2018529931A (ja) 2018-10-11
JP7094700B2 (ja) 2022-07-04

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