ES273263A1 - Toxoids and their production - Google Patents
Toxoids and their productionInfo
- Publication number
- ES273263A1 ES273263A1 ES0273263A ES273263A ES273263A1 ES 273263 A1 ES273263 A1 ES 273263A1 ES 0273263 A ES0273263 A ES 0273263A ES 273263 A ES273263 A ES 273263A ES 273263 A1 ES273263 A1 ES 273263A1
- Authority
- ES
- Spain
- Prior art keywords
- diphtheria
- toxoids
- aliphatic diamine
- formaldehyde
- vaccines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Toxoids are obtained from purified bacterial toxins by treating said toxins in an aqueous medium with formaldehyde in the presence of an aliphatic diamine of molecular weight below 200 which contains a primary or secondary amino group. The toxoids are believed to be represented by the formula [t] (CH2.Y)n, in which [t] represents the radical formed from a bacterial toxin molecule by the loss of one or more hydrogen atoms on groups reactive with formaldehyde, Y represents the radical formed by the loss of a hydrogen atom from an amino group of a molecule of an aliphatic diamine of molecular weight below 200, and n is a positive number. Specified aliphatic diamines, as defined above, are lysine and ethylenediamine. The said aliphatic diamines may be used in admixture with other amines, e.g. alanine. Examples illustrate the preparation of diphtheria toxoids, aqueous solutions of which may be used as diphtheria vaccines, including diphtheria-tetanus and diphtheria-pertussiotetanus vaccines. According to the Provisional Specification, arginine is a further example of a suitable aliphatic diamine, as defined above.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB50861A GB969772A (en) | 1961-01-05 | 1961-01-05 | Toxoids and their production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES273263A1 true ES273263A1 (en) | 1962-07-01 |
Family
ID=9705586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0273263A Expired ES273263A1 (en) | 1961-01-05 | 1961-12-27 | Toxoids and their production |
Country Status (3)
| Country | Link |
|---|---|
| CH (1) | CH455146A (en) |
| ES (1) | ES273263A1 (en) |
| GB (1) | GB969772A (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9216351D0 (en) * | 1992-07-31 | 1992-09-16 | Wellcome Found | Vaccine production |
| GB2495341B (en) | 2011-11-11 | 2013-09-18 | Novartis Ag | Fermentation methods and their products |
| DE102011118371B4 (en) | 2011-11-11 | 2014-02-13 | Novartis Ag | Composition suitable for human vaccination, comprising a diphtheria toxoid, and process for its preparation |
| EP2592137A1 (en) | 2011-11-11 | 2013-05-15 | Novartis AG | Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use |
| DE102011122891B4 (en) | 2011-11-11 | 2014-12-24 | Novartis Ag | Fermentation medium, which is free of animal components, for the preparation of diphtheria toxoids for use in the vaccination of humans |
| GB2498112A (en) * | 2011-11-11 | 2013-07-03 | Novartis Ag | Preparation of a diphtheria toxoid by incubating toxin concentrate with an amino acid and formaldehyde |
-
1961
- 1961-01-05 GB GB50861A patent/GB969772A/en not_active Expired
- 1961-12-27 ES ES0273263A patent/ES273263A1/en not_active Expired
- 1961-12-29 CH CH1513061A patent/CH455146A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH455146A (en) | 1968-04-30 |
| GB969772A (en) | 1964-09-16 |
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