ES272199A1 - Substituted 1-(pyrimidinyl methyl)-piperazines - Google Patents

Substituted 1-(pyrimidinyl methyl)-piperazines

Info

Publication number
ES272199A1
ES272199A1 ES0272199A ES272199A ES272199A1 ES 272199 A1 ES272199 A1 ES 272199A1 ES 0272199 A ES0272199 A ES 0272199A ES 272199 A ES272199 A ES 272199A ES 272199 A1 ES272199 A1 ES 272199A1
Authority
ES
Spain
Prior art keywords
alkyl
piperazine
pyrimidine
reacting
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0272199A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES272199A1 publication Critical patent/ES272199A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula: <FORM:0952131/C2/1> where R and R11 are C1-5-alkyl groups, R1 is a hydrogen atom or a C1-5-alkyl or C2-5-alkenyl group, and n is 0, 1 or 2 and their acid addition salts and their preparation (1) by reacting a strong inorganic acid ester of a 4-amino-2-(C1-5-alkyl)-5-hydroxymethyl-pyrimidine with a piperazine of formula: <FORM:0952131/C2/2> and (2) by reacting a 4-amino-2-(C1-5-alkyl)-5-halomethyl-pyrimidine with an appropriate N-unsubstituted piperazine and treating the product with an alkylating or alkenylating agent. 1,3-Dimethylpiperazine is prepared by treating 1-carbethoxy-3-methyl-piperazine with lithium aluminium hydride. Poultry feeds contain a dispersed compound I or acid addition salt of the invention feed supplements contain the substances dispersed in an edible inert carrier or diluent. Solids and water are carriers mentioned. The compounds act against coccidiosis.
ES0272199A 1960-10-31 1961-10-19 Substituted 1-(pyrimidinyl methyl)-piperazines Expired ES272199A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6592460A 1960-10-31 1960-10-31

Publications (1)

Publication Number Publication Date
ES272199A1 true ES272199A1 (en) 1962-03-16

Family

ID=22066049

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0272199A Expired ES272199A1 (en) 1960-10-31 1961-10-19 Substituted 1-(pyrimidinyl methyl)-piperazines

Country Status (6)

Country Link
BE (1) BE609587A (en)
CH (1) CH413846A (en)
DE (1) DE1445111A1 (en)
ES (1) ES272199A1 (en)
GB (1) GB952131A (en)
SE (1) SE307497B (en)

Also Published As

Publication number Publication date
CH413846A (en) 1966-05-31
GB952131A (en) 1964-03-11
BE609587A (en) 1962-04-25
DE1445111A1 (en) 1968-10-24
SE307497B (en) 1969-01-07

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