ES2721526T3 - Procedimiento para detectar carcinogénesis en el cuello uterino - Google Patents

Procedimiento para detectar carcinogénesis en el cuello uterino Download PDF

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Publication number
ES2721526T3
ES2721526T3 ES15751091T ES15751091T ES2721526T3 ES 2721526 T3 ES2721526 T3 ES 2721526T3 ES 15751091 T ES15751091 T ES 15751091T ES 15751091 T ES15751091 T ES 15751091T ES 2721526 T3 ES2721526 T3 ES 2721526T3
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ES
Spain
Prior art keywords
protein
prb
cervix
detection
carcinogenesis
Prior art date
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Active
Application number
ES15751091T
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English (en)
Inventor
Vincenzo Maccallini
Benedetto Giuseppe Di
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Di Benedetto Federica
Di Benedetto Ludovica
Di Benedetto Nicole
Iakusheva Marina
Original Assignee
Di Benedetto Federica
Di Benedetto Ludovica
Di Benedetto Nicole
Iakusheva Marina
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Publication date
Application filed by Di Benedetto Federica, Di Benedetto Ludovica, Di Benedetto Nicole, Iakusheva Marina filed Critical Di Benedetto Federica
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Publication of ES2721526T3 publication Critical patent/ES2721526T3/es
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57411—Specifically defined cancers of cervix
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44747—Composition of gel or of carrier mixture
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

Abstract

Un procedimiento para detectar una transformación de células neoplásicas inducida por el papilomavirus humano (PVH) en mujeres que se someten a un cribado para el carcinoma de cuello uterino, que comprende detectar, en muestras de células tomadas de la unión pavimentoso-cilíndrica del epitelio del cuello uterino de una paciente a la que se está examinando, la presencia de un complejo de proteínas E6/p53 producido por la proteína E6 con la proteína p53 yo un complejo de proteínas E7/pRb producido por la proteína E7 con la proteína pRb, en el que la detección de dichos dos complejos de proteínas muestra que en la paciente examinada la carcinogénesis se ha vuelto irreversible, realizándose dicha detección mediante el uso combinado de anticuerpos anti-proteína E6, anticuerpos anti-proteína E7, de anticuerpos anti-proteína p53 y anticuerpos anti-proteína pRb.
ES15751091T 2014-05-07 2015-05-07 Procedimiento para detectar carcinogénesis en el cuello uterino Active ES2721526T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM20140225 2014-05-07
PCT/IT2015/000126 WO2015170360A1 (en) 2014-05-07 2015-05-07 Method for detecting carcinogenesis in the uterine cervix

Publications (1)

Publication Number Publication Date
ES2721526T3 true ES2721526T3 (es) 2019-08-01

Family

ID=51136646

Family Applications (1)

Application Number Title Priority Date Filing Date
ES15751091T Active ES2721526T3 (es) 2014-05-07 2015-05-07 Procedimiento para detectar carcinogénesis en el cuello uterino

Country Status (11)

Country Link
US (1) US20170074881A1 (es)
EP (1) EP3140655B1 (es)
CN (1) CN107003313A (es)
AU (1) AU2015257259A1 (es)
BR (1) BR112016025913B1 (es)
CA (1) CA2983712C (es)
ES (1) ES2721526T3 (es)
IL (1) IL248688B (es)
PT (1) PT3140655T (es)
RU (1) RU2702334C2 (es)
WO (1) WO2015170360A1 (es)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1195438A1 (en) * 2000-10-06 2002-04-10 Rijksuniversiteit te Groningen Genetic immunisation against cervical carcinoma
EP1386929A1 (en) * 2002-07-29 2004-02-04 MTM Laboratories AG Peptides associated with tumors and uses related thereto
US20100003704A1 (en) * 2008-06-13 2010-01-07 Shuling Cheng IN SITU detection of early stages and late stages HPV infection
CN101550181B (zh) * 2008-04-03 2011-08-03 清华大学深圳研究生院 人乳头瘤病毒16型e7蛋白功能拮抗肽及其编码基因与应用
JP2012526286A (ja) * 2009-05-07 2012-10-25 オンコヘルス コーポレーション ヒトパピローマウイルス（ｈｐｖ）およびｈｐｖ関連癌の初期段階および後期段階の検出、スクリーニング、および診断のための高度または≧ｃｉｎ２の同定
JP5819851B2 (ja) * 2010-01-08 2015-11-24 オンコヘルス コーポレーション Ｈｐｖ関連の癌の治療及びスクリーニングのための細胞に基づいた高処理能力ｈｐｖ免疫アッセイ
CN203249922U (zh) * 2013-02-22 2013-10-23 艾托金生物医药（苏州）有限公司 用于检测抗人乳头瘤病毒抗体的免疫检测试剂盒

Also Published As

Publication number Publication date
IL248688A0 (en) 2017-01-31
US20170074881A1 (en) 2017-03-16
EP3140655B1 (en) 2018-12-12
CN107003313A (zh) 2017-08-01
WO2015170360A1 (en) 2015-11-12
RU2702334C2 (ru) 2019-10-08
EP3140655A1 (en) 2017-03-15
RU2016147204A (ru) 2018-06-07
BR112016025913A2 (es) 2017-08-15
BR112016025913B1 (pt) 2023-12-12
IL248688B (en) 2019-11-28
CA2983712C (en) 2022-04-19
AU2015257259A8 (en) 2016-12-22
PT3140655T (pt) 2019-03-22
RU2016147204A3 (es) 2018-12-29
AU2015257259A1 (en) 2016-12-15
WO2015170360A4 (en) 2015-12-30
CA2983712A1 (en) 2015-11-12

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