ES2704056T3 - Compuestos de epoxicetona para la inhibición de enzimas - Google Patents
Compuestos de epoxicetona para la inhibición de enzimas Download PDFInfo
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- ES2704056T3 ES2704056T3 ES15821964T ES15821964T ES2704056T3 ES 2704056 T3 ES2704056 T3 ES 2704056T3 ES 15821964 T ES15821964 T ES 15821964T ES 15821964 T ES15821964 T ES 15821964T ES 2704056 T3 ES2704056 T3 ES 2704056T3
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- 201000010044 viral meningitis Diseases 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462024024P | 2014-07-14 | 2014-07-14 | |
| PCT/US2015/040459 WO2016011088A2 (en) | 2014-07-14 | 2015-07-14 | Epoxyketone compounds for enzyme inhibition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2704056T3 true ES2704056T3 (es) | 2019-03-14 |
Family
ID=55079165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15821964T Active ES2704056T3 (es) | 2014-07-14 | 2015-07-14 | Compuestos de epoxicetona para la inhibición de enzimas |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10640533B2 (OSRAM) |
| EP (1) | EP3166933B1 (OSRAM) |
| JP (1) | JP6608442B2 (OSRAM) |
| KR (2) | KR102360356B1 (OSRAM) |
| CN (1) | CN105960399B (OSRAM) |
| DK (1) | DK3166933T3 (OSRAM) |
| ES (1) | ES2704056T3 (OSRAM) |
| PT (1) | PT3166933T (OSRAM) |
| TR (1) | TR201816372T4 (OSRAM) |
| WO (1) | WO2016011088A2 (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2704056T3 (es) | 2014-07-14 | 2019-03-14 | Centrax Int Inc | Compuestos de epoxicetona para la inhibición de enzimas |
| EP4041747A4 (en) * | 2019-10-11 | 2023-10-18 | Mayo Foundation for Medical Education and Research | PROTEASOME HIBITORS |
| WO2024140736A1 (zh) * | 2022-12-27 | 2024-07-04 | 上海美悦生物科技发展有限公司 | 三肽环氧酮化合物、药物组合物及其制备方法和用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2562411A1 (en) | 2004-04-15 | 2005-11-10 | Proteolix, Inc. | Compounds for enzyme inhibition |
| US20050256324A1 (en) * | 2004-05-10 | 2005-11-17 | Proteolix, Inc. | Synthesis of amino acid keto-epoxides |
| ES2408216T3 (es) * | 2004-12-07 | 2013-06-19 | Onyx Therapeutics, Inc. | Composición para la inhibición del proteasoma |
| US7687456B2 (en) | 2005-11-09 | 2010-03-30 | Proteolix, Inc. | Compounds for enzyme inhibition |
| WO2008140782A2 (en) * | 2007-05-10 | 2008-11-20 | Proteolix, Inc. | Compounds for enzyme inhibition |
| PE20120059A1 (es) * | 2008-10-21 | 2012-02-27 | Onyx Therapeutics Inc | Combinaciones farmaceuticas con epoxicetonas peptidicas |
| WO2011136905A2 (en) | 2010-04-07 | 2011-11-03 | Onyx Therapeutics, Inc. | Crystalline peptide epoxyketone immunoproteasome inhibitor |
| HUE060305T2 (hu) * | 2011-08-30 | 2023-02-28 | Tufts College | FAP-aktivált proteaszóma inhibitorok a szolid tumorok kezelésére |
| EP2874997A4 (en) | 2012-07-19 | 2016-01-06 | Univ Drexel | NEW SIGMA RECEPTOR LIGANDS AND METHOD FOR REGULATING CELLULAR PROTEIN HOMEOSTASIS THEREWITH |
| WO2014018807A1 (en) * | 2012-07-26 | 2014-01-30 | Centrax International, Inc. | Peptide epoxyketone compounds |
| WO2014026282A1 (en) * | 2012-08-14 | 2014-02-20 | Abdelmalik Slassi | Fluorinated epoxyketone-based compounds and uses thereof as proteasome inhibitors |
| US20150218212A1 (en) * | 2012-08-21 | 2015-08-06 | Fluorinov Pharma Inc. | Fluorinated epoxyketone-based tetrapeptide compounds and uses thereof as proteasome inhibitors |
| ES2704056T3 (es) | 2014-07-14 | 2019-03-14 | Centrax Int Inc | Compuestos de epoxicetona para la inhibición de enzimas |
-
2015
- 2015-07-14 ES ES15821964T patent/ES2704056T3/es active Active
- 2015-07-14 PT PT15821964T patent/PT3166933T/pt unknown
- 2015-07-14 KR KR1020177004070A patent/KR102360356B1/ko active Active
- 2015-07-14 WO PCT/US2015/040459 patent/WO2016011088A2/en not_active Ceased
- 2015-07-14 JP JP2017523185A patent/JP6608442B2/ja active Active
- 2015-07-14 EP EP15821964.2A patent/EP3166933B1/en active Active
- 2015-07-14 CN CN201580002532.1A patent/CN105960399B/zh active Active
- 2015-07-14 TR TR2018/16372T patent/TR201816372T4/tr unknown
- 2015-07-14 US US15/325,998 patent/US10640533B2/en active Active
- 2015-07-14 KR KR1020217022768A patent/KR102462240B1/ko active Active
- 2015-07-14 DK DK15821964.2T patent/DK3166933T3/en active
-
2019
- 2019-10-28 US US16/665,010 patent/US10787482B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6608442B2 (ja) | 2019-11-20 |
| WO2016011088A2 (en) | 2016-01-21 |
| CN105960399B (zh) | 2018-09-25 |
| US10787482B2 (en) | 2020-09-29 |
| TR201816372T4 (tr) | 2018-11-21 |
| PT3166933T (pt) | 2018-12-06 |
| EP3166933B1 (en) | 2018-08-01 |
| US20200087343A1 (en) | 2020-03-19 |
| WO2016011088A3 (en) | 2016-08-11 |
| KR20210093378A (ko) | 2021-07-27 |
| JP2017522383A (ja) | 2017-08-10 |
| KR20170041747A (ko) | 2017-04-17 |
| US20170158734A1 (en) | 2017-06-08 |
| EP3166933A2 (en) | 2017-05-17 |
| DK3166933T3 (en) | 2018-11-26 |
| CN105960399A (zh) | 2016-09-21 |
| EP3166933A4 (en) | 2017-07-19 |
| US10640533B2 (en) | 2020-05-05 |
| KR102462240B1 (ko) | 2022-11-03 |
| KR102360356B1 (ko) | 2022-02-08 |
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