ES2684599T3 - Células adherentes de la placenta y uso de las mismas en el tratamiento de enfermedades - Google Patents
Células adherentes de la placenta y uso de las mismas en el tratamiento de enfermedades Download PDFInfo
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- ES2684599T3 ES2684599T3 ES15183125.2T ES15183125T ES2684599T3 ES 2684599 T3 ES2684599 T3 ES 2684599T3 ES 15183125 T ES15183125 T ES 15183125T ES 2684599 T3 ES2684599 T3 ES 2684599T3
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Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010003019A (es) | 2007-09-19 | 2010-04-30 | Pluristem Ltd | Celulas adherentes de los tejidos adiposo y de placenta y uso de las mismas en la terapia. |
| US9358320B2 (en) | 2008-04-25 | 2016-06-07 | Allosource | Multi-layer tissue patches |
| US9480549B2 (en) | 2008-04-25 | 2016-11-01 | Allosource | Multi-layer tissue patches |
| AU2009252722A1 (en) | 2008-05-27 | 2009-12-03 | Pluristem Ltd. | Methods of treating inflammatory colon diseases |
| CA2735790C (en) | 2008-09-02 | 2017-02-28 | Pluristem Ltd. | Adherent cells from placenta tissue and use thereof in therapy |
| ES2684599T3 (es) | 2009-11-30 | 2018-10-03 | Pluristem Ltd. | Células adherentes de la placenta y uso de las mismas en el tratamiento de enfermedades |
| WO2011147967A1 (en) | 2010-05-27 | 2011-12-01 | Georg Duda | Skeletal muscle regeneration using mesenchymal stem cells |
| EP2625264B1 (en) | 2010-10-08 | 2022-12-07 | Terumo BCT, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| KR20210144909A (ko) * | 2010-12-17 | 2021-11-30 | 안트로제네시스 코포레이션 | 양막 유래 부착성 세포를 사용한, 면역-관련 질환 및 장애의 치료 |
| WO2012127320A1 (en) | 2011-03-22 | 2012-09-27 | Pluristem Ltd. | Methods for treating radiation or chemical injury |
| CN108342350A (zh) | 2011-04-15 | 2018-07-31 | 普拉里斯坦有限公司 | 收获细胞的方法和系统 |
| CN102586184B (zh) * | 2011-09-05 | 2013-10-23 | 博雅干细胞科技有限公司 | 建立胎盘间充质干细胞库的方法 |
| WO2013070734A1 (en) | 2011-11-07 | 2013-05-16 | Chaudhry Hina W | Methods of cardiac repair |
| WO2013082417A1 (en) * | 2011-11-30 | 2013-06-06 | Anthrogenesis Corporation | Treatment using placental stem cells |
| US9162011B2 (en) | 2011-12-19 | 2015-10-20 | Allosource | Flowable matrix compositions and methods |
| WO2013168850A1 (ko) * | 2012-05-09 | 2013-11-14 | 삼성전자 주식회사 | 이동통신 시스템에서 불연속 수신을 제어하는 방법 및 장치 |
| SG10201700435XA (en) | 2012-09-04 | 2017-02-27 | Pluristem Ltd | Methods for prevention and treatment of preeclampsia |
| WO2014038864A1 (ko) * | 2012-09-05 | 2014-03-13 | 아주대학교산학협력단 | 태아연골유래 세포를 이용한 면역질환의 예방 및 치료용 조성물 |
| AU2013311288B2 (en) | 2012-09-06 | 2015-04-16 | Pluristem Ltd. | Devices and methods for culture of cells |
| JP2015536326A (ja) * | 2012-10-19 | 2015-12-21 | アントフロゲネシス コーポレーション | 羊膜由来接着細胞を利用する疼痛の治療 |
| KR101654970B1 (ko) * | 2013-02-20 | 2016-09-06 | 사회복지법인 삼성생명공익재단 | 줄기세포를 유효성분으로 포함하는 뇌 염증성 질환의 치료용 조성물 |
| AU2014248873B2 (en) | 2013-03-13 | 2017-03-23 | Allosource | Fascia fibrous compositions and methods for their use and manufacture |
| WO2014141111A1 (en) * | 2013-03-14 | 2014-09-18 | Pluristem Ltd. | Methods for prevention and treatment of graft-versus-host disease |
| EP2970882B1 (en) | 2013-03-15 | 2018-11-28 | AlloSource | Cell repopulated collagen matrix for soft tissue repair and regeneration |
| US10039792B1 (en) * | 2013-03-16 | 2018-08-07 | Brahm Holdings, Llc | Methods for the treatment of inflammation and pain using human birth tissue material composition |
| WO2015013862A1 (en) * | 2013-07-29 | 2015-02-05 | Qualcomm Incorporated | Dynamic indication of time division (tdd) duplex uplink/downlink subframe configurations |
| US10058572B2 (en) * | 2013-08-15 | 2018-08-28 | The Regents Of The University Of California | Placenta-derived multipotent stem cells |
| JP6612227B2 (ja) | 2013-11-16 | 2019-11-27 | テルモ ビーシーティー、インコーポレーテッド | バイオリアクターにおける細胞増殖 |
| KR101832203B1 (ko) | 2013-12-06 | 2018-02-27 | 알로소스 | 조직의 시트를 건조하는 방법 |
| EP3114206B1 (en) | 2014-03-04 | 2020-07-29 | Pluristem Ltd. | Systems and methods for growing and harvesting cells |
| EP3613841B1 (en) | 2014-03-25 | 2022-04-20 | Terumo BCT, Inc. | Passive replacement of media |
| GB201406716D0 (en) * | 2014-04-15 | 2014-05-28 | Insphero Ag | Method of preparing cells for 3D tissue culture |
| WO2016049421A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled feed |
| WO2016098061A1 (en) | 2014-12-18 | 2016-06-23 | Pluristem Ltd. | Methods and compositions for treating and preventing muscle wasting disorders |
| IL294058A (en) | 2015-03-23 | 2022-08-01 | Pluristem Ltd | Use of adherent stromal cells to encourage the formation of blood cells in the patient |
| US11146376B2 (en) | 2015-04-22 | 2021-10-12 | Qualcomm Incorporated | System type dependent master information block (MIB) |
| US10334617B2 (en) * | 2015-06-16 | 2019-06-25 | Qualcomm Incorporated | System information for enhanced machine type communication |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| TW201733600A (zh) | 2016-01-29 | 2017-10-01 | 帝聖工業公司 | 胎兒扶持組織物及使用方法 |
| AU2017220148A1 (en) | 2016-02-18 | 2018-07-19 | Pluristem Ltd. | Methods and compositions for treating cancers and neoplasms |
| US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| IL264536B2 (en) | 2016-08-24 | 2023-09-01 | Arthrex Inc | Use of tissue for injury repair |
| US10772986B2 (en) | 2017-01-26 | 2020-09-15 | Allosource | Fascia fibrous compositions and methods for their use and manufacture |
| JP7393945B2 (ja) | 2017-03-31 | 2023-12-07 | テルモ ビーシーティー、インコーポレーテッド | 細胞増殖 |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| WO2018198012A1 (en) | 2017-04-24 | 2018-11-01 | Pluristem Ltd. | Methods and compositions for treating neurological disorders |
| EP3704225B1 (en) * | 2017-10-27 | 2023-10-11 | Alis Pharma Ltd. | Fetal tissue extract, methods for producing the extract, and the use thereof |
| CN110090227B (zh) * | 2018-04-18 | 2021-03-26 | 浙江大学 | 人羊膜上皮细胞在治疗移植物抗宿主病中的用途 |
| CN108904799A (zh) * | 2018-07-09 | 2018-11-30 | 夏荣木 | 一种抗肿瘤制剂及制备的方法 |
| CN109652363A (zh) * | 2018-11-13 | 2019-04-19 | 广东唯泰生物科技有限公司 | 胎盘壁蜕膜间充质干细胞分化为子宫内膜上皮细胞的方法 |
| US11511017B2 (en) | 2019-03-12 | 2022-11-29 | Arthrex, Inc. | Ligament reconstruction |
| CN112423649B (zh) * | 2019-04-30 | 2023-02-10 | 阿里斯制药有限公司 | 胎儿组织提取物、其生产方法及其用途 |
| CN113322228B (zh) * | 2021-04-13 | 2022-08-19 | 广东唯泰生物科技有限公司 | 用于治疗肿瘤的壁蜕膜间充质干细胞培养基、共培方法 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5902741A (en) | 1986-04-18 | 1999-05-11 | Advanced Tissue Sciences, Inc. | Three-dimensional cartilage cultures |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| US5629186A (en) | 1994-04-28 | 1997-05-13 | Lockheed Martin Corporation | Porous matrix and method of its production |
| US6132463A (en) | 1995-05-19 | 2000-10-17 | Etex Corporation | Cell seeding of ceramic compositions |
| EP1064353B1 (en) | 1998-03-18 | 2002-11-06 | Massachusetts Institute Of Technology | Vascularized perfused microtissue/micro-organ arrays |
| RU2249039C2 (ru) | 1999-02-04 | 2005-03-27 | Текнион Рисерч Энд Дивелопмент Фаундейшн Лтд. | Способ размножения/поддержания недифференцированных гемопоэтических стволовых клеток или клеток-предшественников (варианты), способ приготовления кондиционированной среды стромальных клеток, способ трансплантации недифференцированных гемопоэтических стволовых клеток или клеток-предшественников (варианты) |
| ATE384124T1 (de) | 2000-02-26 | 2008-02-15 | Artecel Inc | Pluripotente stammzellen erzeugt aus stromalzellen aus dem fettgewebe und deren verwendungen |
| US20080152629A1 (en) * | 2000-12-06 | 2008-06-26 | James Edinger | Placental stem cell populations |
| US7504099B2 (en) | 2001-12-27 | 2009-03-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods of inducing or enhancing connective tissue repair |
| US7534606B2 (en) * | 2004-01-12 | 2009-05-19 | National Health Research Institutes | Placental stem cell and methods thereof |
| SI1835924T1 (sl) * | 2004-12-23 | 2013-12-31 | Ethicon, Incorporated | Zdravljenje Parkinsonove bolezni in sorodnih obolenj z uporabo celic, pridobljenih post partum |
| EP1979050B1 (en) * | 2005-12-28 | 2017-04-19 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using postpartum-derived cells |
| US20110171182A1 (en) | 2006-03-23 | 2011-07-14 | Pluristem Ltd. | Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy |
| SG170761A1 (en) | 2006-03-23 | 2011-05-30 | Pluristem Ltd | Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy |
| US20110293583A1 (en) | 2006-03-23 | 2011-12-01 | Pluristem Ltd. | Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy |
| PT2120977E (pt) * | 2007-02-12 | 2013-09-16 | Anthrogenesis Corp | Tratamento de doenças inflamatórias utilizando células estaminais da placenta |
| MX2010003019A (es) | 2007-09-19 | 2010-04-30 | Pluristem Ltd | Celulas adherentes de los tejidos adiposo y de placenta y uso de las mismas en la terapia. |
| AU2009252722A1 (en) | 2008-05-27 | 2009-12-03 | Pluristem Ltd. | Methods of treating inflammatory colon diseases |
| WO2010026574A2 (en) | 2008-09-02 | 2010-03-11 | Pluristem Ltd. | Adherent cells from placenta tissue and use thereof in therapy |
| CA2735790C (en) | 2008-09-02 | 2017-02-28 | Pluristem Ltd. | Adherent cells from placenta tissue and use thereof in therapy |
| US20110256108A1 (en) | 2008-09-02 | 2011-10-20 | Moran Meiron | Methods of selection of cells for transplantation |
| ES2684599T3 (es) | 2009-11-30 | 2018-10-03 | Pluristem Ltd. | Células adherentes de la placenta y uso de las mismas en el tratamiento de enfermedades |
| US20130039892A1 (en) | 2010-04-23 | 2013-02-14 | Pluristem Ltd. | Adherent stromal cells derived from plancentas of multiple donors and uses thereof |
| WO2011147967A1 (en) | 2010-05-27 | 2011-12-01 | Georg Duda | Skeletal muscle regeneration using mesenchymal stem cells |
| US20140017209A1 (en) | 2011-03-22 | 2014-01-16 | Pluristem Ltd. | Methods for treating radiation or chemical injury |
| CN108342350A (zh) | 2011-04-15 | 2018-07-31 | 普拉里斯坦有限公司 | 收获细胞的方法和系统 |
| SG10201700435XA (en) | 2012-09-04 | 2017-02-27 | Pluristem Ltd | Methods for prevention and treatment of preeclampsia |
| AU2013311288B2 (en) | 2012-09-06 | 2015-04-16 | Pluristem Ltd. | Devices and methods for culture of cells |
| WO2014068508A2 (en) | 2012-10-31 | 2014-05-08 | Pluristem Ltd. | Method and device for thawing biological material |
| US10351910B2 (en) | 2013-02-20 | 2019-07-16 | Pluristem Ltd | Gene and protein expression properties of adherent stromal cells cultured in 3D |
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