ES267839A1 - Procedimiento de obtenciën de un nonapeptido - Google Patents
Procedimiento de obtenciën de un nonapeptidoInfo
- Publication number
- ES267839A1 ES267839A1 ES0267839A ES267839A ES267839A1 ES 267839 A1 ES267839 A1 ES 267839A1 ES 0267839 A ES0267839 A ES 0267839A ES 267839 A ES267839 A ES 267839A ES 267839 A1 ES267839 A1 ES 267839A1
- Authority
- ES
- Spain
- Prior art keywords
- carbobenzoxy
- phenylalanyl
- arginine
- nitro
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 230000001681 protective effect Effects 0.000 abstract 4
- RRONHWAVOYADJL-HNNXBMFYSA-N (2s)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoic acid Chemical compound C([C@@H](C(=O)O)NC(=O)OCC=1C=CC=CC=1)C1=CC=CC=C1 RRONHWAVOYADJL-HNNXBMFYSA-N 0.000 abstract 3
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 3
- -1 p-nitrobenzyl ester Chemical class 0.000 abstract 3
- JXGVXCZADZNAMJ-NSHDSACASA-N (2s)-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid Chemical compound OC(=O)[C@@H]1CCCN1C(=O)OCC1=CC=CC=C1 JXGVXCZADZNAMJ-NSHDSACASA-N 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 2
- 125000002435 L-phenylalanyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 108010029020 prolylglycine Proteins 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 239000007858 starting material Substances 0.000 abstract 2
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- MRAUNPAHJZDYCK-BYPYZUCNSA-N L-nitroarginine Chemical compound OC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O MRAUNPAHJZDYCK-BYPYZUCNSA-N 0.000 abstract 1
- 229930182821 L-proline Natural products 0.000 abstract 1
- RNKSNIBMTUYWSH-YFKPBYRVSA-N L-prolylglycine Chemical compound [O-]C(=O)CNC(=O)[C@@H]1CCC[NH2+]1 RNKSNIBMTUYWSH-YFKPBYRVSA-N 0.000 abstract 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 abstract 1
- 229960000583 acetic acid Drugs 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 1
- 239000012362 glacial acetic acid Substances 0.000 abstract 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 abstract 1
- 229910000042 hydrogen bromide Inorganic materials 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- NDBQJIBNNUJNHA-DFWYDOINSA-N methyl (2s)-2-amino-3-hydroxypropanoate;hydrochloride Chemical compound Cl.COC(=O)[C@@H](N)CO NDBQJIBNNUJNHA-DFWYDOINSA-N 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- KGCNHWXDPDPSBV-UHFFFAOYSA-N p-nitrobenzyl chloride Chemical compound [O-][N+](=O)C1=CC=C(CCl)C=C1 KGCNHWXDPDPSBV-UHFFFAOYSA-N 0.000 abstract 1
- 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 abstract 1
- 230000003836 peripheral circulation Effects 0.000 abstract 1
- 229960002429 proline Drugs 0.000 abstract 1
- 108010087846 prolyl-prolyl-glycine Proteins 0.000 abstract 1
- 102220007331 rs111033633 Human genes 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH633460A CH390933A (de) | 1960-06-02 | 1960-06-02 | Verfahren zur Herstellung eines blutdrucksenkenden Polypeptids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES267839A1 true ES267839A1 (es) | 1961-11-16 |
Family
ID=4307896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0267839A Expired ES267839A1 (es) | 1960-06-02 | 1961-05-31 | Procedimiento de obtenciën de un nonapeptido |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3256267A (en, 2012) |
| CH (1) | CH390933A (en, 2012) |
| ES (1) | ES267839A1 (en, 2012) |
| FR (1) | FR1468M (en, 2012) |
| GB (1) | GB980383A (en, 2012) |
| LU (1) | LU40205A1 (en, 2012) |
| OA (1) | OA01250A (en, 2012) |
| SE (1) | SE301154B (en, 2012) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU798098A1 (ru) * | 1977-12-14 | 1981-01-23 | Ордена Трудового Красного Знамениинститут Органического Синтезаан Латвийской Ccp | Циклический аналог брадикинина,обла-дАющий СпОСОбНОСТью СОздАВАТь пРОлОНги-РОВАННый дЕпРЕССОРНый эффЕКТ B эКСпЕРиМЕН-TE ,A ТАКжЕ ВАСКул РНую пРОНи-цАЕМОСТь B эКСпЕРиМЕНТЕ |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2793204A (en) * | 1955-03-29 | 1957-05-21 | Organon Nv | Process for the synthesis of peptides |
| US2854443A (en) * | 1955-10-12 | 1958-09-30 | Saul & Co | Alyl-oxytocin and process for the preparation thereof |
| US3040017A (en) * | 1958-07-08 | 1962-06-19 | Ciba Geigy Corp | Octapeptides |
| CH425812A (de) * | 1958-09-05 | 1966-12-15 | Ciba Geigy | Verfahren zur Herstellung von arginylgruppenhaltigen Peptiden |
-
1960
- 1960-06-02 CH CH633460A patent/CH390933A/de unknown
-
1961
- 1961-05-12 GB GB17401/61A patent/GB980383A/en not_active Expired
- 1961-05-29 US US113129A patent/US3256267A/en not_active Expired - Lifetime
- 1961-05-31 ES ES0267839A patent/ES267839A1/es not_active Expired
- 1961-05-31 LU LU40205A patent/LU40205A1/xx unknown
- 1961-06-01 SE SE5779/61A patent/SE301154B/xx unknown
- 1961-08-30 FR FR871980A patent/FR1468M/fr not_active Expired
-
1964
- 1964-12-31 OA OA51497A patent/OA01250A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH390933A (de) | 1965-04-30 |
| OA01250A (fr) | 1969-01-25 |
| FR1468M (fr) | 1962-09-03 |
| GB980383A (en) | 1965-01-13 |
| SE301154B (en, 2012) | 1968-05-27 |
| US3256267A (en) | 1966-06-14 |
| LU40205A1 (en, 2012) | 1961-12-01 |
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