ES2671927T3 - Ácido 2-[5-[N-(4-fluorofenil)carbamoil]pirimidin-2-ilsulfanilmetil]-4-(trifluorometoxi)fenil]borónico - Google Patents
Ácido 2-[5-[N-(4-fluorofenil)carbamoil]pirimidin-2-ilsulfanilmetil]-4-(trifluorometoxi)fenil]borónico Download PDFInfo
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- ES2671927T3 ES2671927T3 ES13750432.0T ES13750432T ES2671927T3 ES 2671927 T3 ES2671927 T3 ES 2671927T3 ES 13750432 T ES13750432 T ES 13750432T ES 2671927 T3 ES2671927 T3 ES 2671927T3
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| PCT/US2013/053376 WO2015016938A1 (en) | 2013-08-02 | 2013-08-02 | 2- [5- [n- (4 -fluorophenyl) carbamoyl] pyrimidin- 2 - ylsulfanylmethyl] -4- (trifluoromet hoxy) phenyl] boronic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2671927T3 true ES2671927T3 (es) | 2018-06-11 |
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| KR (1) | KR102107372B1 (enExample) |
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| EP3027627B1 (en) * | 2013-08-02 | 2018-01-31 | Syntrix Biosystems Inc. | 2-[5-[n-(4-fluorophenyl)carbamoyl]pyrimidin-2-ylsulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid |
| US8969365B2 (en) | 2013-08-02 | 2015-03-03 | Syntrix Biosystems, Inc. | Thiopyrimidinecarboxamides as CXCR1/2 modulators |
| US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
| JP2019135244A (ja) * | 2019-04-03 | 2019-08-15 | シントリックス・バイオシステムズ・インコーポレイテッドＳｙｎｔｒｉｘ Ｂｉｏｓｙｓｔｅｍｓ， Ｉｎｃ． | ２−［５−［ｎ−（４−フルオロフェニル）カルバモイル］ピリミジン−２−イルスルファニルメチル］−４−（トリフルオロメトキシ）フェニル」ボロン酸 |
| CN117954000A (zh) * | 2023-12-29 | 2024-04-30 | 中山大学附属口腔医院 | 用于筛选对治疗牙周炎及认知障碍的化合物的方法及用途 |
| WO2025193763A1 (en) * | 2024-03-12 | 2025-09-18 | Syntrix Biosystems Inc. | Method for increasing survival in patients with cancer |
| EP4686469A1 (en) * | 2024-07-31 | 2026-02-04 | Dompé farmaceutici SpA | Cxcl8 inhibitors for use in the treatment of diabetes-associated comorbidities |
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| US5411947A (en) | 1989-06-28 | 1995-05-02 | Vestar, Inc. | Method of converting a drug to an orally available form by covalently bonding a lipid to the drug |
| US5475120A (en) | 1990-11-02 | 1995-12-12 | University Of Florida | Method for the isolation and purification of taxol and its natural analogues |
| US5194635A (en) | 1991-03-18 | 1993-03-16 | Virginia Tech Intellectual Properties, Inc. | Rearranged taxol compounds and method of using in testing of in vivo activity |
| US5416225A (en) | 1992-03-30 | 1995-05-16 | Sloan-Kettering Institute For Cancer Research | Total synthesis of taxol |
| US5488116A (en) | 1992-03-30 | 1996-01-30 | Sloan-Kettering Institute For Cancer Research | Total synthesis of taxol and analogues thereof |
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| US5411984A (en) | 1992-10-16 | 1995-05-02 | Virginia Tech Intellectual Properties, Inc. | Water soluble analogs and prodrugs of taxol |
| CA2126698A1 (en) | 1992-12-07 | 1994-06-23 | Muraleedharan G. Nair | Process for the isolation and purification of taxol and taxanes from taxus spp. |
| US5468769A (en) | 1993-07-15 | 1995-11-21 | Abbott Laboratories | Paclitaxel derivatives |
| FR2707642B1 (fr) | 1993-07-16 | 1995-10-13 | Electricite De France | Dérivés de polyéthers et d'hétérocycles pentacycliques, leurs polymères et leurs applications, notamment à la complexation d'ions métalliques. |
| US5405972A (en) | 1993-07-20 | 1995-04-11 | Florida State University | Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes |
| US5565478A (en) | 1994-03-14 | 1996-10-15 | The United States Of America As Represented By The Department Of Health & Human Services | Combination therapy using signal transduction inhibitors with paclitaxel and other taxane analogs |
| US5508447A (en) | 1994-05-24 | 1996-04-16 | Board Of Regents, The University Of Texas System | Short synthetic route to taxol and taxol derivatives |
| US5489589A (en) | 1994-12-07 | 1996-02-06 | Bristol-Myers Squibb Company | Amino acid derivatives of paclitaxel |
| SE9903544D0 (sv) * | 1999-10-01 | 1999-10-01 | Astra Pharma Prod | Novel compounds |
| EP2942346B1 (en) * | 2009-02-17 | 2020-05-06 | Syntrix Biosystems, Inc. | Pyridinecarboxamides as cxcr2 modulators |
| AU2011293612B2 (en) * | 2010-08-23 | 2015-11-26 | Syntrix Biosystems Inc. | Aminopyridine- and aminopyrimidinecarboxamides as CXCR2 modulators |
| EP3027627B1 (en) * | 2013-08-02 | 2018-01-31 | Syntrix Biosystems Inc. | 2-[5-[n-(4-fluorophenyl)carbamoyl]pyrimidin-2-ylsulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid |
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| CN105683202B (zh) | 2019-05-10 |
| JP2016525573A (ja) | 2016-08-25 |
| CN110200979A (zh) | 2019-09-06 |
| JP6509851B2 (ja) | 2019-05-08 |
| KR102107372B1 (ko) | 2020-05-07 |
| KR20160051765A (ko) | 2016-05-11 |
| MX359556B (es) | 2018-10-02 |
| CA2920172C (en) | 2020-03-10 |
| AU2019203931A1 (en) | 2019-06-27 |
| WO2015016938A1 (en) | 2015-02-05 |
| IL243913A0 (en) | 2016-04-21 |
| MX2016001490A (es) | 2017-01-05 |
| CA2920172A1 (en) | 2015-02-05 |
| DK3027627T3 (en) | 2018-05-22 |
| AU2013395662A1 (en) | 2016-03-10 |
| EP3027627B1 (en) | 2018-01-31 |
| AU2013395662B2 (en) | 2019-03-14 |
| CN105683202A (zh) | 2016-06-15 |
| EP3027627A1 (en) | 2016-06-08 |
| AU2019203931B2 (en) | 2020-06-11 |
| NO3027627T3 (enExample) | 2018-06-30 |
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