ES2662847T3 - Formulaciones novedosas de inhalación - Google Patents
Formulaciones novedosas de inhalación Download PDFInfo
- Publication number
- ES2662847T3 ES2662847T3 ES14174889.7T ES14174889T ES2662847T3 ES 2662847 T3 ES2662847 T3 ES 2662847T3 ES 14174889 T ES14174889 T ES 14174889T ES 2662847 T3 ES2662847 T3 ES 2662847T3
- Authority
- ES
- Spain
- Prior art keywords
- lactose monohydrate
- monohydrate particles
- inhalation formulations
- volume
- particle size
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Una formulación en polvo seco que comprende a. un dihidrato de fumarato de 5 formoterol micronizado y budesonida micronizada y, b. monohidrato de lactosa como un portador que comprende partículas de monohidrato de lactosa finas y partículas de monohidrato de lactosa gruesas; el tamaño de partícula d0.5 por volumen de las partículas de monohidrato de lactosa finas está entre 0.5 μm y 25 μm y el tamaño de partícula d0.5 por volumen de las partículas de monohidrato de lactosa gruesas está entre 40 μm y 200 μm, caracterizado porque la densidad a granel vertida de la formulación en polvo seco está entre 0.42 g/ml y 0.57 g/ml.
Description
Claims (1)
-
imagen1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR201307891 | 2013-07-01 | ||
TR201307891 | 2013-07-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2662847T3 true ES2662847T3 (es) | 2018-04-10 |
Family
ID=49674361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES14174889.7T Active ES2662847T3 (es) | 2013-07-01 | 2014-06-30 | Formulaciones novedosas de inhalación |
Country Status (5)
Country | Link |
---|---|
EP (2) | EP2821061B1 (es) |
ES (1) | ES2662847T3 (es) |
PL (1) | PL2821061T3 (es) |
PT (1) | PT2821061T (es) |
TR (1) | TR201802969T4 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107929257B (zh) * | 2017-12-01 | 2019-04-16 | 广东一力集团制药股份有限公司 | 一种酒石酸阿福特罗粉吸入剂胶囊及其制备方法 |
WO2020240350A1 (en) * | 2019-05-24 | 2020-12-03 | Glenmark Pharmaceutical Limited | An inhalable fixed dose powder composition comprising glycopyrronium, formoterol and fluticasone propionate |
EP4108230A1 (en) * | 2021-06-24 | 2022-12-28 | Laboratoires SMB | New dry powder composition of tiotropium for inhalation |
WO2023187393A1 (en) | 2022-03-31 | 2023-10-05 | Hovione Scientia Limited | Inhalation composite and carrier based formulation combination |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4140689B4 (de) | 1991-12-10 | 2007-11-22 | Boehringer Ingelheim Kg | Inhalationspulver und Verfahren zu ihrer Herstellung |
GB9404945D0 (en) | 1994-03-15 | 1994-04-27 | Glaxo Group Ltd | Pharmaceutical composition |
SE9700134D0 (sv) | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
SE9700135D0 (sv) | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
SE9700133D0 (sv) | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
EP0876814A1 (en) | 1997-05-07 | 1998-11-11 | "PHARLYSE", Société Anonyme | Dry powder inhaler excipient, process for its preparation and pharmaceutical compositions containing it |
ES2192866T3 (es) * | 1998-11-13 | 2003-10-16 | Jago Res Ag | Polvo seco para inhalacion. |
PE20011227A1 (es) * | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
FI20002177A0 (fi) * | 2000-10-02 | 2000-10-02 | Orion Yhtymae Oyj | Uusi yhdistelmä astman hoitoon |
GB0030074D0 (en) * | 2000-12-08 | 2001-01-24 | Univ London Pharmacy | Particulate inhalation carrier |
KR101369631B1 (ko) * | 2002-08-21 | 2014-03-05 | 노턴 헬스케어 리미티드 | 흡입용 조성물 |
-
2014
- 2014-06-30 ES ES14174889.7T patent/ES2662847T3/es active Active
- 2014-06-30 EP EP14174889.7A patent/EP2821061B1/en active Active
- 2014-06-30 PL PL14174889T patent/PL2821061T3/pl unknown
- 2014-06-30 EP EP14174925.9A patent/EP2821062A1/en active Pending
- 2014-06-30 TR TR2018/02969T patent/TR201802969T4/tr unknown
- 2014-06-30 PT PT141748897T patent/PT2821061T/pt unknown
Also Published As
Publication number | Publication date |
---|---|
TR201802969T4 (tr) | 2018-03-21 |
PT2821061T (pt) | 2018-03-13 |
EP2821061B1 (en) | 2017-12-20 |
PL2821061T3 (pl) | 2018-05-30 |
EP2821062A1 (en) | 2015-01-07 |
EP2821061A1 (en) | 2015-01-07 |
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