ES2651007T3 - Formulación de interferón beta de acción prolongada que usa un fragmento de inmunoglobulina - Google Patents

Formulación de interferón beta de acción prolongada que usa un fragmento de inmunoglobulina Download PDF

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ES2651007T3
ES2651007T3 ES11763095.4T ES11763095T ES2651007T3 ES 2651007 T3 ES2651007 T3 ES 2651007T3 ES 11763095 T ES11763095 T ES 11763095T ES 2651007 T3 ES2651007 T3 ES 2651007T3
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formulation
long
beta
interferon
interferon beta
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Dae Jin Kim
Min Young Kim
Jin Sun Kim
Sung Hee Hong
Sung Youb Jung
Se Chang Kwon
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Hanmi Science Co Ltd
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Hanmi Science Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K2317/00—Immunoglobulins specific features
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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Abstract

Una formulación de interferón beta de acción prolongada que tiene una duración y una estabilidad in vivo mejoradas, que comprende un conjugado de interferón beta que se compone de un interferón beta unido a una región Fc de inmunoglobulina a través de un polímero no peptídico seleccionado entre el grupo que consiste en polietilenglicol, polipropilenglicol, copolímeros de etilenglicol y propilenglicol, polioles polioxietilados, alcohol polivinílico, polisacáridos, dextrano, éter poliviniletílico, polímeros biodegradables, polímeros lipídicos, quitinas, ácido hialurónico y una combinación de los mismos, en la que el interferón beta es un interferón beta 1b

Description

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Claims (1)

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ES11763095.4T 2010-04-02 2011-04-04 Formulación de interferón beta de acción prolongada que usa un fragmento de inmunoglobulina Active ES2651007T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20100030577 2010-04-02
KR20100030577 2010-04-02
PCT/KR2011/002335 WO2011122923A2 (en) 2010-04-02 2011-04-04 Long-acting interferon beta formulation using immunoglobulin fragment

Publications (1)

Publication Number Publication Date
ES2651007T3 true ES2651007T3 (es) 2018-01-23

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ES11763095.4T Active ES2651007T3 (es) 2010-04-02 2011-04-04 Formulación de interferón beta de acción prolongada que usa un fragmento de inmunoglobulina

Country Status (8)

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US (1) US9421244B2 (es)
EP (1) EP2552422B1 (es)
JP (2) JP6110295B2 (es)
KR (1) KR101330407B1 (es)
AR (1) AR080993A1 (es)
ES (1) ES2651007T3 (es)
TW (1) TWI423813B (es)
WO (1) WO2011122923A2 (es)

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EP2552422A2 (en) 2013-02-06
JP2013523724A (ja) 2013-06-17
US20130028867A1 (en) 2013-01-31
KR20110111268A (ko) 2011-10-10
EP2552422B1 (en) 2017-09-06
TWI423813B (zh) 2014-01-21
US9421244B2 (en) 2016-08-23
JP6110295B2 (ja) 2017-04-05
WO2011122923A2 (en) 2011-10-06
WO2011122923A3 (en) 2012-03-08
JP2016135772A (ja) 2016-07-28
AR080993A1 (es) 2012-05-30
EP2552422A4 (en) 2014-01-08
TW201201831A (en) 2012-01-16
KR101330407B1 (ko) 2013-11-15

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