ES2650688T3 - Biomaterial y método para su realización - Google Patents

Biomaterial y método para su realización Download PDF

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Publication number
ES2650688T3
ES2650688T3 ES10816354.4T ES10816354T ES2650688T3 ES 2650688 T3 ES2650688 T3 ES 2650688T3 ES 10816354 T ES10816354 T ES 10816354T ES 2650688 T3 ES2650688 T3 ES 2650688T3
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Spain
Prior art keywords
tricalcium phosphate
microns
granules
dimension
biomaterial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10816354.4T
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English (en)
Inventor
Giovanni Faccioli
Renzo Soffiatti
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Tecres SpA
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Tecres SpA
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Publication date
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Publication of ES2650688T3 publication Critical patent/ES2650688T3/es
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0036—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/16—Materials with shape-memory or superelastic properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Composite Materials (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)

Abstract

Biomaterial de composite, biocompatible, utilizable como sistema de administración de fármacos o como espaciador o como sustituto óseo, tal como por ejemplo para rellenar lagunas óseas o para sustituir partes dañadas del tejido óseo, o para fijar prótesis de varios tipos, o para engrosar los huesos debilitados por enfermedades tales como osteoporosis o similares, que comprende un componente adaptado para formar una matriz estructural porosa y un componente soluble, en donde dicho componente adaptado para formar una matriz estructural porosa comprende uno o más componentes seleccionados de componentes poliméricos, en donde dicho componente soluble comprende fosfato tricálcico, en donde dicho fosfato tricálcico está en forma de polvo y gránulos, en donde dicho fosfato tricálcico en forma de polvo tiene una dimensión inferior a 100 micras, en donde dicho fosfato tricálcico en forma de polvo, cuando se disuelve, determina la formación de espacios vacíos que constituyen una porosidad formada por microcavidades con una dimensión inferior a 100 micras, caracterizado porque dicho fosfato tricálcico en forma de gránulos tiene una dimensión comprendida entre 200 y 500 micras, y porque dicho fosfato tricálcico en forma de gránulos, cuando se disuelve, determina la formación de espacios vacíos que constituyen una porosidad formada por macrocavidades con una dimensión comprendida entre 200 y 500 micras, para tener características de soporte mecánico y características osteoinductivas y osteoconductivas en todo el volumen ocupado por dicho biomaterial.

Description

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Claims (1)

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ES10816354.4T 2010-12-14 2010-12-14 Biomaterial y método para su realización Active ES2650688T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2010/055815 WO2012080782A1 (en) 2010-12-14 2010-12-14 Biomaterial and method for its realisation

Publications (1)

Publication Number Publication Date
ES2650688T3 true ES2650688T3 (es) 2018-01-19

Family

ID=44279678

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10816354.4T Active ES2650688T3 (es) 2010-12-14 2010-12-14 Biomaterial y método para su realización

Country Status (13)

Country Link
US (1) US9408697B2 (es)
EP (1) EP2651460B1 (es)
JP (1) JP5886313B2 (es)
KR (2) KR101994053B1 (es)
CN (1) CN103796688B (es)
AR (1) AR082922A1 (es)
AU (1) AU2010365643B2 (es)
BR (1) BR112013014536B1 (es)
CA (1) CA2817817C (es)
ES (1) ES2650688T3 (es)
HU (1) HUE035984T2 (es)
PL (1) PL2651460T3 (es)
WO (1) WO2012080782A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10603172B2 (en) * 2014-11-06 2020-03-31 Tecres S.P.A. Absorbing eluting spacer device
DE102016211201A1 (de) * 2016-06-22 2017-12-28 Aesculap Ag Medizinisches Produkt, vorzugsweise zur Anwendung bei der Behandlung einer Knochenkavität, Verfahren zur Herstellung des medizinischen Produkts sowie medizinisches Kit
CN107412850A (zh) * 2017-09-01 2017-12-01 苏州大学 一种表面降解的可注射骨填充材料及其制备方法
WO2024062316A1 (en) * 2022-09-23 2024-03-28 Tecres S.P.A. Solid and compact biomaterial, method for its preparation and kit for filling bone cavities

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5085861A (en) * 1987-03-12 1992-02-04 The Beth Israel Hospital Association Bioerodable implant composition comprising crosslinked biodegradable polyesters
ITMI20010089A1 (it) * 2001-01-18 2002-07-18 Consiglio Nazionale Ricerche Metodo per l'ottenimento di un materiale composito polimero/ceramico bicompatibile avente una porosita' predeterminata
US7294187B2 (en) * 2001-01-24 2007-11-13 Ada Foundation Rapid-hardening calcium phosphate cement compositions
CN1200043C (zh) * 2003-06-20 2005-05-04 四川大学 无机－有机纳米复合生物活性多孔材料及其制备方法
TWI327071B (en) * 2005-09-09 2010-07-11 Wright Medical Tech Inc Composite bone graft substitute cement and articles produced therefrom
BRPI0617086B8 (pt) 2005-09-09 2021-06-22 Agnovos Healtcare Llc cimento composto substituto de enxerto ósseo e artigos dele originados
WO2007084725A2 (en) * 2006-01-19 2007-07-26 Osteotech, Inc. Injectable and moldable bone substitute materials
EP1891984A1 (en) * 2006-08-24 2008-02-27 Graftys Macroporous and highly resorbable apatitic calcium-phosphate cement
GB0618963D0 (en) * 2006-09-26 2006-11-08 Ucl Business Plc Formulations and composites with reactive fillers
JP5257646B2 (ja) * 2006-11-20 2013-08-07 独立行政法人科学技術振興機構 分散体、分散体の製造方法、リン酸カルシウム中空粒子の製造方法、リン酸カルシウム多孔質体の製造方法、リン酸カルシウム複合微粒子の製造方法、及びそれらの利用

Also Published As

Publication number Publication date
AU2010365643A1 (en) 2013-06-20
HUE035984T2 (hu) 2018-06-28
KR20180026543A (ko) 2018-03-12
KR20130123402A (ko) 2013-11-12
JP5886313B2 (ja) 2016-03-16
KR101994053B1 (ko) 2019-06-27
PL2651460T3 (pl) 2018-04-30
CA2817817C (en) 2018-05-01
US9408697B2 (en) 2016-08-09
CN103796688B (zh) 2016-06-29
CN103796688A (zh) 2014-05-14
JP2013545570A (ja) 2013-12-26
BR112013014536A2 (pt) 2017-09-26
CA2817817A1 (en) 2012-06-21
EP2651460A1 (en) 2013-10-23
BR112013014536B1 (pt) 2018-10-23
US20130274891A1 (en) 2013-10-17
WO2012080782A1 (en) 2012-06-21
EP2651460B1 (en) 2017-10-11
AU2010365643B2 (en) 2016-02-04
AR082922A1 (es) 2013-01-16

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