ES2650263T3 - Dinámica de la razón de SFLT-1 o endoglina/PLGF como indicador para preeclampsia inminente y/o síndrome de HELLP - Google Patents

Dinámica de la razón de SFLT-1 o endoglina/PLGF como indicador para preeclampsia inminente y/o síndrome de HELLP Download PDF

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Publication number
ES2650263T3
ES2650263T3 ES12784579.0T ES12784579T ES2650263T3 ES 2650263 T3 ES2650263 T3 ES 2650263T3 ES 12784579 T ES12784579 T ES 12784579T ES 2650263 T3 ES2650263 T3 ES 2650263T3
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Prior art keywords
sample
sflt
preeclampsia
plgf
subject
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ES12784579.0T
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English (en)
Spanish (es)
Inventor
Barbara DENK
Martin Hund
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/18—Water
    • G01N33/1826—Organic contamination in water
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/18—Water

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ES12784579.0T 2011-11-09 2012-11-08 Dinámica de la razón de SFLT-1 o endoglina/PLGF como indicador para preeclampsia inminente y/o síndrome de HELLP Active ES2650263T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11188422 2011-11-09
EP11188422 2011-11-09
PCT/EP2012/072157 WO2013068475A1 (en) 2011-11-09 2012-11-08 Dynamic of sflt-1 or endoglin/plgf ratio as an indicator for imminent preeclampsia and/or hellp syndrome

Publications (1)

Publication Number Publication Date
ES2650263T3 true ES2650263T3 (es) 2018-01-17

Family

ID=47178005

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12784579.0T Active ES2650263T3 (es) 2011-11-09 2012-11-08 Dinámica de la razón de SFLT-1 o endoglina/PLGF como indicador para preeclampsia inminente y/o síndrome de HELLP

Country Status (7)

Country Link
US (3) US10302657B2 (enExample)
EP (1) EP2776839B1 (enExample)
JP (1) JP6034394B2 (enExample)
CN (1) CN103917875B (enExample)
CA (1) CA2850449C (enExample)
ES (1) ES2650263T3 (enExample)
WO (1) WO2013068475A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6568533B2 (ja) * 2014-01-24 2019-08-28 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 産後ｈｅｌｌｐ症候群、産後子癇または産後妊娠高血圧腎症の予測
WO2016123163A2 (en) 2015-01-27 2016-08-04 Kardiatonos, Inc. Biomarkers of vascular disease
CN107636466B (zh) * 2015-02-18 2020-07-21 阿斯顿大学 先兆子痫的诊断性测定和治疗
EP3423834B1 (en) 2016-02-29 2022-08-17 Roche Diagnostics GmbH Igfbp-7 as a marker in preeclampsia
CN107884570A (zh) * 2016-09-29 2018-04-06 韦彦余 一种孕妇先兆子痫检测试剂盒
JP2020533595A (ja) * 2017-09-13 2020-11-19 プロジェニティ， インコーポレイテッド 子癇前症バイオマーカならびに関連するシステムおよび方法
CN112673259B (zh) * 2018-07-20 2024-11-22 豪夫迈·罗氏有限公司 基于igfbp-7的先兆子痫预测
EP4070113A4 (en) 2019-12-04 2023-12-20 Biora Therapeutics, Inc. ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS
JP2025500751A (ja) * 2021-12-08 2025-01-15 ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング 早発性子癇前症の予後についてのバイオマーカー
CN115308423B (zh) * 2022-10-10 2023-02-10 天津云检医疗器械有限公司 用于先兆子痫风险预测、评估或诊断的生物标志物、试剂盒及方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
OA12890A (en) 2002-07-19 2006-10-13 Beth Israel Hospital Methods of diagnosing and treating pre-eclampsia or eclampsia.
US7435419B2 (en) * 2002-07-19 2008-10-14 Beth Israel Deaconess Medical Center Methods of diagnosing and treating pre-eclampsia or eclampsia
MX2007003522A (es) * 2004-09-24 2007-06-11 Beth Israel Hospital Complicaciones del embarazo.
US7740849B2 (en) * 2004-09-24 2010-06-22 Beth Israel Deaconess Medical Center Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders
US20070111326A1 (en) * 2005-11-14 2007-05-17 Abbott Laboratories Diagnostic method for proteinaceous binding pairs, cardiovascular conditions and preeclampsia
US20080071151A1 (en) * 2006-06-30 2008-03-20 Sogin David C Method and Apparatus for Diagnosing Pre-eclampsia
US20090068683A1 (en) * 2007-06-11 2009-03-12 Mayo Foundation For Medical Education And Research Markers for preeclampsia
EP2037278A1 (en) * 2007-09-11 2009-03-18 F.Hoffmann-La Roche Ag Vascular markers in the remodelling of cardiac injury
JP5715636B2 (ja) * 2009-11-03 2015-05-13 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 循環系事象と虚血性事象を鑑別するためのＮＴ−ｐｒｏＡＮＰおよびＳＦｌｔ−１
GB0921156D0 (en) * 2009-12-02 2010-01-20 Ucl Business Plc Biomarkers of early miscarriage

Also Published As

Publication number Publication date
EP2776839B1 (en) 2017-08-30
JP6034394B2 (ja) 2016-11-30
WO2013068475A1 (en) 2013-05-16
US10302657B2 (en) 2019-05-28
JP2014532887A (ja) 2014-12-08
CN103917875B (zh) 2016-11-09
CA2850449C (en) 2021-06-01
US12352762B2 (en) 2025-07-08
US20190227074A1 (en) 2019-07-25
EP2776839A1 (en) 2014-09-17
CA2850449A1 (en) 2013-05-16
CN103917875A (zh) 2014-07-09
US20220128568A1 (en) 2022-04-28
US20140234879A1 (en) 2014-08-21

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