CA2850449C - Dynamic of sflt-1 or endoglin/pigf ratio as an indicator for imminent preeclampsia and/or hellp syndrome - Google Patents
Dynamic of sflt-1 or endoglin/pigf ratio as an indicator for imminent preeclampsia and/or hellp syndrome Download PDFInfo
- Publication number
- CA2850449C CA2850449C CA2850449A CA2850449A CA2850449C CA 2850449 C CA2850449 C CA 2850449C CA 2850449 A CA2850449 A CA 2850449A CA 2850449 A CA2850449 A CA 2850449A CA 2850449 C CA2850449 C CA 2850449C
- Authority
- CA
- Canada
- Prior art keywords
- ratio
- endoglin
- sflt
- preeclampsia
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/18—Water
- G01N33/1826—Organic contamination in water
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/18—Water
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11188422.7 | 2011-11-09 | ||
| EP11188422 | 2011-11-09 | ||
| PCT/EP2012/072157 WO2013068475A1 (en) | 2011-11-09 | 2012-11-08 | Dynamic of sflt-1 or endoglin/plgf ratio as an indicator for imminent preeclampsia and/or hellp syndrome |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2850449A1 CA2850449A1 (en) | 2013-05-16 |
| CA2850449C true CA2850449C (en) | 2021-06-01 |
Family
ID=47178005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2850449A Active CA2850449C (en) | 2011-11-09 | 2012-11-08 | Dynamic of sflt-1 or endoglin/pigf ratio as an indicator for imminent preeclampsia and/or hellp syndrome |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10302657B2 (enExample) |
| EP (1) | EP2776839B1 (enExample) |
| JP (1) | JP6034394B2 (enExample) |
| CN (1) | CN103917875B (enExample) |
| CA (1) | CA2850449C (enExample) |
| ES (1) | ES2650263T3 (enExample) |
| WO (1) | WO2013068475A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105917233B (zh) * | 2014-01-24 | 2018-07-03 | 豪夫迈·罗氏有限公司 | 产后hellp综合征、产后子痫或产后子痫前期的预测 |
| US11143659B2 (en) | 2015-01-27 | 2021-10-12 | Arterez, Inc. | Biomarkers of vascular disease |
| US10357469B2 (en) * | 2015-02-18 | 2019-07-23 | Aston University | Diagnostic assay and treatment for preeclampsia |
| WO2017148854A1 (en) | 2016-02-29 | 2017-09-08 | Roche Diagnostics Gmbh | Igfbp-7 as a marker in preeclampsia |
| CN107884570A (zh) * | 2016-09-29 | 2018-04-06 | 韦彦余 | 一种孕妇先兆子痫检测试剂盒 |
| US20200264188A1 (en) * | 2017-09-13 | 2020-08-20 | Progenity, Inc. | Preeclampsia biomarkers and related systems and methods |
| JP7557463B2 (ja) * | 2018-07-20 | 2024-09-27 | エフ． ホフマン－ラ ロシュ アーゲー | Ｉｇｆｂｐ－７に基づく妊娠高血圧腎症の予測 |
| EP4070113A4 (en) | 2019-12-04 | 2023-12-20 | Biora Therapeutics, Inc. | ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS |
| CA3239310A1 (en) * | 2021-12-08 | 2023-06-15 | Emmanuel BUJOLD | Biomarkers for prognosis of early onset preeclampsia |
| CN117867094A (zh) * | 2022-10-10 | 2024-04-12 | 天津云检医疗器械有限公司 | 用于先兆子痫风险预测、评估或诊断的生物标志物、试剂盒及方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US7435419B2 (en) * | 2002-07-19 | 2008-10-14 | Beth Israel Deaconess Medical Center | Methods of diagnosing and treating pre-eclampsia or eclampsia |
| ES2440651T3 (es) | 2002-07-19 | 2014-01-29 | Beth Israel Deaconess Medical Center | Método para diagnosticar preeclampsia |
| KR20130119506A (ko) * | 2004-09-24 | 2013-10-31 | 베스 이스라엘 데코니스 메디칼 센터 | 임신성 합병증의 진단 및 치료 방법 |
| US7740849B2 (en) * | 2004-09-24 | 2010-06-22 | Beth Israel Deaconess Medical Center | Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders |
| US20070111326A1 (en) * | 2005-11-14 | 2007-05-17 | Abbott Laboratories | Diagnostic method for proteinaceous binding pairs, cardiovascular conditions and preeclampsia |
| US20080071151A1 (en) * | 2006-06-30 | 2008-03-20 | Sogin David C | Method and Apparatus for Diagnosing Pre-eclampsia |
| US20090068683A1 (en) * | 2007-06-11 | 2009-03-12 | Mayo Foundation For Medical Education And Research | Markers for preeclampsia |
| EP2037278A1 (en) * | 2007-09-11 | 2009-03-18 | F.Hoffmann-La Roche Ag | Vascular markers in the remodelling of cardiac injury |
| ES2549460T3 (es) * | 2009-11-03 | 2015-10-28 | F. Hoffmann-La Roche Ag | NT-pro ANP y sFlt-1 para la diferenciación entre los eventos isquémicos y circulatorios |
| GB0921156D0 (en) * | 2009-12-02 | 2010-01-20 | Ucl Business Plc | Biomarkers of early miscarriage |
-
2012
- 2012-11-08 CN CN201280055316.XA patent/CN103917875B/zh active Active
- 2012-11-08 WO PCT/EP2012/072157 patent/WO2013068475A1/en not_active Ceased
- 2012-11-08 EP EP12784579.0A patent/EP2776839B1/en active Active
- 2012-11-08 JP JP2014540463A patent/JP6034394B2/ja active Active
- 2012-11-08 ES ES12784579.0T patent/ES2650263T3/es active Active
- 2012-11-08 CA CA2850449A patent/CA2850449C/en active Active
-
2014
- 2014-04-29 US US14/264,377 patent/US10302657B2/en active Active
-
2019
- 2019-04-02 US US16/373,098 patent/US20190227074A1/en not_active Abandoned
-
2021
- 2021-09-01 US US17/463,876 patent/US12352762B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6034394B2 (ja) | 2016-11-30 |
| WO2013068475A1 (en) | 2013-05-16 |
| US20220128568A1 (en) | 2022-04-28 |
| CN103917875B (zh) | 2016-11-09 |
| US20190227074A1 (en) | 2019-07-25 |
| EP2776839B1 (en) | 2017-08-30 |
| CA2850449A1 (en) | 2013-05-16 |
| CN103917875A (zh) | 2014-07-09 |
| US10302657B2 (en) | 2019-05-28 |
| US20140234879A1 (en) | 2014-08-21 |
| US12352762B2 (en) | 2025-07-08 |
| EP2776839A1 (en) | 2014-09-17 |
| ES2650263T3 (es) | 2018-01-17 |
| JP2014532887A (ja) | 2014-12-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2850449C (en) | Dynamic of sflt-1 or endoglin/pigf ratio as an indicator for imminent preeclampsia and/or hellp syndrome | |
| MX356775B (es) | Medios y metodos que aplican sflt-1/plgf o relacion de endoglina/plgf para descartar el inicio de preeclampsia en un determinado periodo de tiempo. | |
| EP3182126A3 (en) | Biomarker test for prediction or early detection of preeclampsia and/or hellp syndrome | |
| WO2011128357A3 (en) | Biomarkers for hypertensive disorders of pregnancy | |
| WO2013075055A3 (en) | Kits and methods for assessing appendicitis | |
| WO2013083781A3 (en) | Biomarkers and test panels useful in systemic inflammatory conditions | |
| WO2014036440A3 (en) | Papp-a2 as a marker for monitoring, predicting and diagnosing preeclampsia | |
| WO2013087887A3 (en) | Biomarkers and parameters for preeclampsia | |
| WO2013003350A3 (en) | Microrna biomarkers indicative of alzheimer's disease | |
| WO2012076553A3 (en) | Biomarkers and parameters for hypertensive disorders of pregnancy | |
| WO2012110878A3 (en) | Method of diagnosing cancer and diagnosis kit using measurement of nk cell activity | |
| WO2014143977A3 (en) | Biomarkers and methods for predicting preeclampsia | |
| WO2012175741A3 (en) | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains | |
| WO2013159872A8 (en) | Biomarkers for the diagnosis, prognosis, assessment and therapy stratification of syncope | |
| CN105203392B (zh) | 一种基于表面完整性的钛合金材料低周疲劳寿命预测方法 | |
| TW201144799A (en) | Fill sufficiency method and system | |
| WO2009047283A3 (en) | Means and methods for monitoring myocardial infarction and its treatment | |
| WO2015193325A3 (en) | Ceramides and their use in diagnosing cvd | |
| WO2017029401A8 (en) | Means and methods for diagnosing cardiac disease in a subject | |
| EP2415877A3 (en) | Means and methods for diagnosing pancreatic cancer | |
| WO2020115270A3 (en) | Biomarker for detecting zearalenone effect | |
| NZ602733A (en) | Hbf and a1m as early stage markers for preeclampsia | |
| WO2013052237A3 (en) | Systems and methods for assay of bio-contaminants in water | |
| WO2011063389A3 (en) | Normalization of platelet biomarkers | |
| RU2012149456A (ru) | Способ и система оценки поведения торможения водителя |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20140328 |
|
| EEER | Examination request |
Effective date: 20140328 |