ES2634266T3 - Captura de conformación cromosómica circular (4C) - Google Patents

Captura de conformación cromosómica circular (4C) Download PDF

Info

Publication number
ES2634266T3
ES2634266T3 ES08719319.9T ES08719319T ES2634266T3 ES 2634266 T3 ES2634266 T3 ES 2634266T3 ES 08719319 T ES08719319 T ES 08719319T ES 2634266 T3 ES2634266 T3 ES 2634266T3
Authority
ES
Spain
Prior art keywords
sequences
dna
sequence
restriction enzyme
interest
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08719319.9T
Other languages
English (en)
Spanish (es)
Inventor
Wouter De Laat
Frank Grosveld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Erasmus University Medical Center
Original Assignee
Erasmus University Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erasmus University Medical Center filed Critical Erasmus University Medical Center
Application granted granted Critical
Publication of ES2634266T3 publication Critical patent/ES2634266T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6823Release of bound markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ES08719319.9T 2007-01-11 2008-01-10 Captura de conformación cromosómica circular (4C) Active ES2634266T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US99975007P 2007-01-11 2007-01-11
US999750P 2007-01-11
US97790007P 2007-10-05 2007-10-05
US977900P 2007-10-05
PCT/IB2008/000625 WO2008084405A2 (en) 2007-01-11 2008-01-10 Circular chromosome conformation capture (4c)

Publications (1)

Publication Number Publication Date
ES2634266T3 true ES2634266T3 (es) 2017-09-27

Family

ID=39609120

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08719319.9T Active ES2634266T3 (es) 2007-01-11 2008-01-10 Captura de conformación cromosómica circular (4C)

Country Status (10)

Country Link
US (1) US8642295B2 (https=)
EP (1) EP2121977B1 (https=)
JP (1) JP5690068B2 (https=)
CN (1) CN101688237A (https=)
AU (1) AU2008204338B2 (https=)
BR (1) BRPI0806565A2 (https=)
DK (1) DK2121977T3 (https=)
ES (1) ES2634266T3 (https=)
PT (1) PT2121977T (https=)
WO (1) WO2008084405A2 (https=)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2614118C (en) * 2005-07-04 2013-11-26 Erasmus University Medical Center 4c
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US9074244B2 (en) * 2008-03-11 2015-07-07 Affymetrix, Inc. Array-based translocation and rearrangement assays
HUE052213T2 (hu) 2009-11-06 2021-04-28 Univ Leland Stanford Junior Grafitkilökõdés nem invazív diagnosztizálása szervátültetett betegekben
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
EP2572003A4 (en) 2010-05-18 2016-01-13 Natera Inc METHOD FOR NONINVASIVE PRANATAL PLOIDIE ASSIGNMENT
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
WO2012005595A2 (en) 2010-07-09 2012-01-12 Wouter Leonard De Laat V3-d genomic region of interest sequencing strategies
WO2012088456A2 (en) 2010-12-22 2012-06-28 Natera, Inc. Methods for non-invasive prenatal paternity testing
AU2012211957B2 (en) 2011-02-04 2017-02-23 The Trustees Of The University Of Pennsylvania A method for detecting chromosome structure and gene expression simultaneously in single cells
AU2011358564B9 (en) 2011-02-09 2017-07-13 Natera, Inc Methods for non-invasive prenatal ploidy calling
GB2496016B (en) 2011-09-09 2016-03-16 Univ Leland Stanford Junior Methods for obtaining a sequence
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
EP3885446A1 (en) 2013-02-01 2021-09-29 The Regents of The University of California Methods for genome assembly and haplotype phasing
US9411930B2 (en) 2013-02-01 2016-08-09 The Regents Of The University Of California Methods for genome assembly and haplotype phasing
WO2014144491A1 (en) * 2013-03-15 2014-09-18 The Broad Institute, Inc Methods for determining multiple interactions between nucleic acids in a cell
KR101672531B1 (ko) * 2013-04-18 2016-11-17 주식회사 젠큐릭스 조기 유방암 예후 예측 진단용 유전자 마커 및 이의 용도
GB2517936B (en) * 2013-09-05 2016-10-19 Babraham Inst Chromosome conformation capture method including selection and enrichment steps
EP3049557B1 (en) 2013-09-27 2021-05-05 University of Washington Methods and systems for large scale scaffolding of genome assemblies
GB201320351D0 (en) * 2013-11-18 2014-01-01 Erasmus Universiteit Medisch Ct Method
EP3957749A1 (en) 2014-04-21 2022-02-23 Natera, Inc. Detecting tumour specific mutations in biopsies with whole exome sequencing and in cell-free samples
US20180173845A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
CA2956925C (en) 2014-08-01 2024-02-13 Dovetail Genomics, Llc Tagging nucleic acids for sequence assembly
EP3201350B1 (en) * 2014-09-30 2020-12-02 Global Life Sciences Solutions USA LLC Method for nucleic acid analysis directly from an unpurified biological sample
WO2016094872A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Dead guides for crispr transcription factors
EP3889260A1 (en) 2014-12-12 2021-10-06 The Broad Institute, Inc. Protected guide rnas (pgrnas)
WO2016094874A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Escorted and functionalized guides for crispr-cas systems
WO2016106244A1 (en) 2014-12-24 2016-06-30 The Broad Institute Inc. Crispr having or associated with destabilization domains
NZ734854A (en) 2015-02-17 2022-11-25 Dovetail Genomics Llc Nucleic acid sequence assembly
US11807896B2 (en) 2015-03-26 2023-11-07 Dovetail Genomics, Llc Physical linkage preservation in DNA storage
WO2016182893A1 (en) 2015-05-08 2016-11-17 Teh Broad Institute Inc. Functional genomics using crispr-cas systems for saturating mutagenesis of non-coding elements, compositions, methods, libraries and applications thereof
WO2016183106A1 (en) 2015-05-11 2016-11-17 Natera, Inc. Methods and compositions for determining ploidy
CA3012607A1 (en) 2015-06-18 2016-12-22 The Broad Institute Inc. Crispr enzymes and systems
EP4159856A1 (en) 2015-06-18 2023-04-05 The Broad Institute, Inc. Novel crispr enzymes and systems
US9790490B2 (en) 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
US11802305B2 (en) 2015-06-24 2023-10-31 Oxford BioDynamics PLC Detection processes using sites of chromosome interaction
WO2017061861A1 (en) * 2015-10-05 2017-04-13 Koninklijke Nederlandse Akademie Van Wetenschappen Targeted locus amplification using cloning strategies
CA3002740A1 (en) 2015-10-19 2017-04-27 Dovetail Genomics, Llc Methods for genome assembly, haplotype phasing, and target independent nucleic acid detection
EP3368687B1 (en) 2015-10-27 2021-09-29 The Broad Institute, Inc. Compositions and methods for targeting cancer-specific sequence variations
WO2017106657A1 (en) 2015-12-18 2017-06-22 The Broad Institute Inc. Novel crispr enzymes and systems
JP7441003B2 (ja) 2016-02-23 2024-02-29 ダブテイル ゲノミクス エルエルシー ゲノムアセンブリのためのフェージングされたリードセットの生成とハプロタイプフェージング
WO2017181202A2 (en) 2016-04-15 2017-10-19 Natera, Inc. Methods for lung cancer detection
CN110382692A (zh) 2016-04-19 2019-10-25 博德研究所 新型crispr酶以及系统
EP3445853A1 (en) 2016-04-19 2019-02-27 The Broad Institute, Inc. Cpf1 complexes with reduced indel activity
WO2017197300A1 (en) 2016-05-13 2017-11-16 Dovetail Genomics Llc Recovering long-range linkage information from preserved samples
US12595478B2 (en) 2016-06-29 2026-04-07 The Broad Institute, Inc. Crispr-Cas systems having destabilization domain
WO2018064208A1 (en) 2016-09-28 2018-04-05 The Broad Institute, Inc. Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof
US11485996B2 (en) 2016-10-04 2022-11-01 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
MY190153A (en) * 2016-12-01 2022-03-31 Oxford BioDynamics PLC Application of epigenetic chromosomal interactions in cancer diagnostics
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
CN110225981B (zh) 2016-12-23 2024-03-15 牛津生物动力有限责任公司 分型方法
CN107058484B (zh) * 2016-12-26 2020-06-16 孙涛 一种应用于高通量测序同时检测t细胞和b细胞免疫组库的引物组合及试剂盒
US20210293783A1 (en) 2017-04-18 2021-09-23 The General Hospital Corporation Compositions for detecting secretion and methods of use
ES2987603T3 (es) * 2017-11-03 2024-11-15 Oxford BioDynamics PLC Regulación genética de la respuesta inmunitaria por interacciones cromosómicas
US11873481B2 (en) 2017-11-21 2024-01-16 Arima Genomics, Inc. Preserving spatial-proximal contiguity and molecular contiguity in nucleic acid templates
JP2021506342A (ja) 2017-12-14 2021-02-22 ティーエーアイ ダイアグノスティックス インコーポレイテッドTai Diagnostics,Inc. 移植のための移植片適合性の評価
WO2019152543A1 (en) 2018-01-31 2019-08-08 Dovetail Genomics, Llc Sample prep for dna linkage recovery
CA3090426A1 (en) 2018-04-14 2019-10-17 Natera, Inc. Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna
CN108804872A (zh) * 2018-06-08 2018-11-13 中国农业科学院农业基因组研究所 利用外切酶组合消除三维基因组学技术噪音的方法及应用
CN109033745A (zh) * 2018-06-08 2018-12-18 中国农业科学院农业基因组研究所 一种消除三维基因组学技术噪音的方法及应用
AU2019291907A1 (en) * 2018-06-29 2021-02-18 Grail, Inc. Nucleic acid rearrangement and integration analysis
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
WO2020041380A1 (en) 2018-08-20 2020-02-27 The Broad Institute, Inc. Methods and compositions for optochemical control of crispr-cas9
CN113272441A (zh) 2018-11-20 2021-08-17 阿瑞玛基因组学公司 保留空间邻近连续性信息的制备核酸的方法和组合物
CN109609611A (zh) * 2018-12-26 2019-04-12 上海优甲医疗科技有限公司 一种基于高通量测序技术的基因定量测序方法
US20220235340A1 (en) 2019-05-20 2022-07-28 The Broad Institute, Inc. Novel crispr-cas systems and uses thereof
EP3973073A1 (en) 2019-05-20 2022-03-30 Arima Genomics, Inc. Methods and compositions for enhanced genome coverage and preservation of spatial proximal contiguity
EP3980559A1 (en) 2019-06-06 2022-04-13 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system
CN115803447A (zh) 2020-04-23 2023-03-14 荷兰皇家科学院 染色体邻近实验中的结构变异检测
GB202111194D0 (en) * 2021-08-03 2021-09-15 Cergentis B V Method
WO2025117544A1 (en) 2023-11-29 2025-06-05 The Broad Institute, Inc. Engineered omega guide molecule and iscb compositions, systems, and methods of use thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
DE69132531T2 (de) 1990-12-06 2001-09-13 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Verbindungen und ihre Verwendung in einer binären Synthesestrategie
DE69233501T2 (de) 1991-11-22 2006-02-23 Affymetrix, Inc. (n.d.Ges.d.Staates Delaware), Santa Clara Kombinatorische Strategien für die Polymersynthese
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
JPH09507121A (ja) 1993-10-26 1997-07-22 アフィマックス テクノロジーズ ナームロゼ ベノートスハップ 生物学的チップ上の核酸プローブアレー
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
EP0937159A4 (en) 1996-02-08 2004-10-20 Affymetrix Inc SPECIATION OF MICROORGANISMS FROM MICROPLATES AND CHARACTERIZATION OF THE PHENOTYPES THEREOF
US6126939A (en) 1996-09-03 2000-10-03 Yeda Research And Development Co. Ltd. Anti-inflammatory dipeptide and pharmaceutical composition thereof
CA2481312A1 (en) 2002-03-08 2003-09-18 The Babraham Institute Tagging and recovery of elements associated with target molecules
CA2614118C (en) * 2005-07-04 2013-11-26 Erasmus University Medical Center 4c

Also Published As

Publication number Publication date
CN101688237A (zh) 2010-03-31
EP2121977A2 (en) 2009-11-25
JP5690068B2 (ja) 2015-03-25
WO2008084405A3 (en) 2009-01-29
US20100062947A1 (en) 2010-03-11
PT2121977T (pt) 2017-08-18
AU2008204338B2 (en) 2014-03-06
WO2008084405A2 (en) 2008-07-17
DK2121977T3 (en) 2017-09-18
JP2010515449A (ja) 2010-05-13
AU2008204338A1 (en) 2008-07-17
AU2008204338A8 (en) 2009-08-06
BRPI0806565A2 (pt) 2014-05-06
US8642295B2 (en) 2014-02-04
EP2121977B1 (en) 2017-06-21

Similar Documents

Publication Publication Date Title
ES2634266T3 (es) Captura de conformación cromosómica circular (4C)
AU2006264564B2 (en) Chromosome conformation capture-on-chip (4c) assay
US20250290122A1 (en) Typing and Assembling Discontinuous Genomic Elements
CN116438316A (zh) 用于肿瘤学诊断的无细胞核酸和单细胞组合分析
ES2235177T3 (es) Hibridacion comparativa con conjuntos ordenados de acidos nucleicos.
ES2745814T3 (es) Transposición conservadora de contigüidad
JP7058502B2 (ja) ゲノム適用および治療適用のための、核酸分子のクローン複製および増幅のためのシステムおよび方法
CN111492068B (zh) 与寡核苷酸相关联的颗粒
CN105992825A (zh) 用于分析三维dna结构中的核苷酸序列相互作用的方法
JP2005525786A (ja) アレイを用いた遺伝子モザイクの検出方法
Class et al. Patent application title: CIRCULAR CHROMOSOME CONFORMATION CAPTURE (4C) Inventors: Wouter De Laat (Rotterdam, NL) Frank Grosveld (Rotterdam, NL) Assignees: Erasmus University Medical Center
CN101238225B (zh) 染色体构象芯片捕获(4c)测定
HK1118870A (en) Chromosome conformation capture-on-chip (4c) assay
Ikebuchi et al. A denaturation-free protocol for in situ visualization of short nuclear DNA sequences using padlock probes with rolling-circle amplification
HK1118870B (en) Chromosome conformation capture-on-chip (4c) assay
CN101238225A (zh) 染色体构象芯片捕获(4c)测定