ES2624767T3 - Potenciación de tratamientos de enfermedades autoinmunitarias e inflamatorias mediante oligonucleótidos inmunorreguladores (IRO) antagonistas de TLR7 y TLR9 - Google Patents
Potenciación de tratamientos de enfermedades autoinmunitarias e inflamatorias mediante oligonucleótidos inmunorreguladores (IRO) antagonistas de TLR7 y TLR9 Download PDFInfo
- Publication number
- ES2624767T3 ES2624767T3 ES10783933.4T ES10783933T ES2624767T3 ES 2624767 T3 ES2624767 T3 ES 2624767T3 ES 10783933 T ES10783933 T ES 10783933T ES 2624767 T3 ES2624767 T3 ES 2624767T3
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- Prior art keywords
- nucleotide
- oligonucleotide
- sugar
- purine
- ribose
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Applications Claiming Priority (3)
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| US18292809P | 2009-06-01 | 2009-06-01 | |
| US182928P | 2009-06-01 | ||
| PCT/US2010/036923 WO2010141483A2 (en) | 2009-06-01 | 2010-06-01 | Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (iro) antagonists of tlr7 and tlr9 |
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| ES2624767T3 true ES2624767T3 (es) | 2017-07-17 |
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| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| EP2640420B1 (en) | 2010-11-19 | 2018-08-15 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| US20130096938A1 (en) * | 2011-10-10 | 2013-04-18 | Abbott Biotechnology Ltd. | Managing healthcare services |
| US9539259B2 (en) | 2012-05-23 | 2017-01-10 | The Johns Hopkins University | Compounds and methods of use thereof for treating neurodegenerative disorders |
| AU2012395641B2 (en) | 2012-11-29 | 2019-10-03 | Sbi Biotech Co., Ltd. | Inhibitory oligonucleotide and use thereof |
| CA2896537C (en) * | 2013-01-08 | 2021-10-12 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| EP2754714A1 (en) * | 2013-01-14 | 2014-07-16 | Sarepta Therapeutics, Inc. | Inhibitory oligonucleotides and their use in therapy |
| AU2015349680A1 (en) | 2014-11-21 | 2017-06-08 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| US20190046638A1 (en) | 2016-04-01 | 2019-02-14 | Checkmate Pharmaceuticals, Inc. | Fc RECEPTOR-MEDIATED DRUG DELIVERY |
| JP7034951B2 (ja) | 2016-06-08 | 2022-03-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 操作されたウイルスベクターは炎症および免疫応答の誘導を低減する |
| US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| WO2019094548A1 (en) | 2017-11-08 | 2019-05-16 | President And Fellows Of Harvard College | Compositions and methods for inhibiting viral vector-induced inflammatory responses |
| WO2019160866A2 (en) | 2018-02-13 | 2019-08-22 | Checkmate Pharmaceuticals, Inc. | Compositions and methods for tumor immunotherapy |
| AU2019251421B2 (en) | 2018-04-09 | 2025-05-01 | Checkmate Pharmaceuticals | Packaging oligonucleotides into virus-like particles |
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| US5399676A (en) * | 1989-10-23 | 1995-03-21 | Gilead Sciences | Oligonucleotides with inverted polarity |
| US6096722A (en) * | 1990-08-14 | 2000-08-01 | Isis Pharmaceuticals Inc. | Antisense modulation of cell adhesion molecule expression and treatment of cell adhesion molecule-associated diseases |
| US7276489B2 (en) * | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
| US7973016B2 (en) | 2004-01-23 | 2011-07-05 | Joslin Diebetes Center | Methods of treating, reducing, or preventing autoimmune conditions |
| EA200800943A1 (ru) * | 2005-09-27 | 2008-12-30 | Коли Фармасьютикал Гмбх | Модуляция tlr-опосредуемых иммунных ответов с использованием олигонуклеотидов-адаптеров |
| US8426375B2 (en) * | 2005-10-12 | 2013-04-23 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| CN104278037B (zh) * | 2005-10-12 | 2020-09-15 | 艾德拉药物股份有限公司 | 基于变异应答调制Toll样受体的免疫调节寡核苷酸(IRO)化合物 |
| US8383598B2 (en) * | 2005-10-12 | 2013-02-26 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| PL2154144T3 (pl) | 2008-08-06 | 2015-04-30 | Changchun Huapu Biotechnology Co Ltd | Oligonukleotydy i ich zastosowanie |
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| EP2437791B1 (en) | 2017-03-22 |
| US20110171209A1 (en) | 2011-07-14 |
| WO2010141483A2 (en) | 2010-12-09 |
| CA2762206C (en) | 2017-06-27 |
| CN102612561A (zh) | 2012-07-25 |
| CA2762206A1 (en) | 2010-12-09 |
| US8987221B2 (en) | 2015-03-24 |
| EP2437791A2 (en) | 2012-04-11 |
| JP6275380B2 (ja) | 2018-02-07 |
| JP2012528867A (ja) | 2012-11-15 |
| WO2010141483A3 (en) | 2012-03-01 |
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