ES2614755T3 - Medición acumulativa de un analito - Google Patents
Medición acumulativa de un analito Download PDFInfo
- Publication number
- ES2614755T3 ES2614755T3 ES13730047.1T ES13730047T ES2614755T3 ES 2614755 T3 ES2614755 T3 ES 2614755T3 ES 13730047 T ES13730047 T ES 13730047T ES 2614755 T3 ES2614755 T3 ES 2614755T3
- Authority
- ES
- Spain
- Prior art keywords
- analyte
- sample
- measurement
- concentration
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000012491 analyte Substances 0.000 title claims abstract description 86
- 238000005259 measurement Methods 0.000 title claims abstract description 54
- 230000001186 cumulative effect Effects 0.000 title description 5
- 238000000034 method Methods 0.000 claims abstract description 40
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 48
- 239000008103 glucose Substances 0.000 claims description 48
- 239000007788 liquid Substances 0.000 claims description 16
- 210000003722 extracellular fluid Anatomy 0.000 claims description 6
- 230000008859 change Effects 0.000 claims description 2
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 abstract description 3
- 239000000523 sample Substances 0.000 description 27
- 238000001514 detection method Methods 0.000 description 16
- 238000000605 extraction Methods 0.000 description 15
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 108090000790 Enzymes Proteins 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- 229940088598 enzyme Drugs 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 5
- 241000282898 Sus scrofa Species 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000012806 monitoring device Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 235000012208 gluconic acid Nutrition 0.000 description 2
- 239000000174 gluconic acid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 240000009298 Zingiber montanum Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 230000008822 capillary blood flow Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 239000011244 liquid electrolyte Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 229960001078 lithium Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000004377 microelectronic Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000135 prohibitive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
- A61B5/150061—Means for enhancing collection
- A61B5/150091—Means for enhancing collection by electricity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150977—Arrays of piercing elements for simultaneous piercing
- A61B5/150984—Microneedles or microblades
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04C—ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
- F04C2270/00—Control; Monitoring or safety arrangements
- F04C2270/04—Force
- F04C2270/041—Controlled or regulated
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Optics & Photonics (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Ecology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1208950.4A GB2502287B (en) | 2012-05-21 | 2012-05-21 | Cumulative measurement of an analyte |
| GB201208950 | 2012-05-21 | ||
| PCT/GB2013/051322 WO2013175196A1 (en) | 2012-05-21 | 2013-05-21 | Cumulative measurement of an analyte |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2614755T3 true ES2614755T3 (es) | 2017-06-01 |
Family
ID=46546441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13730047.1T Active ES2614755T3 (es) | 2012-05-21 | 2013-05-21 | Medición acumulativa de un analito |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10092224B2 (enExample) |
| EP (1) | EP2852323B1 (enExample) |
| JP (1) | JP6538554B2 (enExample) |
| CN (1) | CN104470428B (enExample) |
| AU (1) | AU2013264992B2 (enExample) |
| BR (1) | BR112014028850B1 (enExample) |
| CA (1) | CA2873616C (enExample) |
| ES (1) | ES2614755T3 (enExample) |
| GB (1) | GB2502287B (enExample) |
| IN (1) | IN2014KN02847A (enExample) |
| PL (1) | PL2852323T3 (enExample) |
| WO (1) | WO2013175196A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3372165A1 (en) * | 2017-03-07 | 2018-09-12 | Koninklijke Philips N.V. | Enhanced sampling using applied energy |
| US11478606B1 (en) | 2020-01-08 | 2022-10-25 | New Heights Energy, LLC | Wearable devices and methods for providing therapy to a user and/or for measuring physiological parameters of the user |
| WO2023172676A2 (en) | 2022-03-10 | 2023-09-14 | New Heights Energy, LLC | Wearable devices, systems, and methods for providing therapy to a user and/or for measuring physiological parameters of the user |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL312299A1 (en) | 1993-07-02 | 1996-04-15 | Unipath Ltd | Method of as well as apparatus and test set for monitoring ovulation |
| US6587705B1 (en) * | 1998-03-13 | 2003-07-01 | Lynn Kim | Biosensor, iontophoretic sampling system, and methods of use thereof |
| ATE258028T1 (de) * | 1998-05-13 | 2004-02-15 | Cygnus Therapeutic Systems | Signalverarbeitung zur messung von physiologischen analyten |
| WO2001088534A2 (en) * | 2000-05-16 | 2001-11-22 | Cygnus, Inc. | Methods for improving performance and reliability of biosensors |
| CN1311233C (zh) * | 2001-10-26 | 2007-04-18 | 爱科来株式会社 | 特定成份的浓度测定方法和浓度测定装置 |
| AU2002346484A1 (en) * | 2001-11-21 | 2003-06-10 | Optiscan Biomedical Corporation | Method and apparatus for improving the accuracy of alternative site analyte concentration measurements |
| EP1489961B1 (en) * | 2002-03-22 | 2010-09-29 | Animas Technologies LLC | Improving performance of an analyte monitoring device |
| US20040253736A1 (en) * | 2003-06-06 | 2004-12-16 | Phil Stout | Analytical device with prediction module and related methods |
| US7258673B2 (en) * | 2003-06-06 | 2007-08-21 | Lifescan, Inc | Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein |
| KR100868566B1 (ko) * | 2007-03-29 | 2008-11-13 | 케이엠에이치 주식회사 | 포도당 농도 측정 장치 및 그를 이용한 포도당 농도를측정하는 방법 |
| JP5186887B2 (ja) * | 2007-11-09 | 2013-04-24 | オムロンヘルスケア株式会社 | 血中成分濃度測定装置および血中成分濃度測定方法 |
| CN101983339B (zh) * | 2008-03-31 | 2015-09-23 | 希森美康株式会社 | 制样装置与制样方法以及细胞分析装置与细胞分析方法 |
| US8192995B2 (en) * | 2008-11-13 | 2012-06-05 | Beckman Coulter, Inc. | Method of correction of particle interference to hemoglobin measurement |
| JP5795368B2 (ja) * | 2010-06-30 | 2015-10-14 | ライフスキャン・スコットランド・リミテッドＬｉｆｅＳｃａｎ Ｓｃｏｔｌａｎｄ， Ｌｔｄ． | 平均の食事前と食事後のグルコース差のメッセージ表示について統計的検出力を確実にするための方法、システム、及び装置 |
-
2012
- 2012-05-21 GB GB1208950.4A patent/GB2502287B/en not_active Expired - Fee Related
-
2013
- 2013-05-21 JP JP2015513264A patent/JP6538554B2/ja active Active
- 2013-05-21 WO PCT/GB2013/051322 patent/WO2013175196A1/en not_active Ceased
- 2013-05-21 US US14/403,098 patent/US10092224B2/en active Active
- 2013-05-21 PL PL13730047T patent/PL2852323T3/pl unknown
- 2013-05-21 AU AU2013264992A patent/AU2013264992B2/en active Active
- 2013-05-21 EP EP13730047.1A patent/EP2852323B1/en active Active
- 2013-05-21 CA CA2873616A patent/CA2873616C/en active Active
- 2013-05-21 CN CN201380026923.8A patent/CN104470428B/zh active Active
- 2013-05-21 ES ES13730047.1T patent/ES2614755T3/es active Active
- 2013-05-21 BR BR112014028850-0A patent/BR112014028850B1/pt not_active IP Right Cessation
-
2014
- 2014-12-08 IN IN2847KON2014 patent/IN2014KN02847A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014028850B1 (pt) | 2021-11-09 |
| US10092224B2 (en) | 2018-10-09 |
| AU2013264992A1 (en) | 2015-01-15 |
| US20150173659A1 (en) | 2015-06-25 |
| BR112014028850A2 (pt) | 2017-06-27 |
| PL2852323T3 (pl) | 2017-04-28 |
| GB2502287B (en) | 2016-11-23 |
| CA2873616A1 (en) | 2013-11-28 |
| GB2502287A (en) | 2013-11-27 |
| CA2873616C (en) | 2020-06-30 |
| CN104470428A (zh) | 2015-03-25 |
| JP6538554B2 (ja) | 2019-07-03 |
| GB201208950D0 (en) | 2012-07-04 |
| EP2852323B1 (en) | 2016-09-07 |
| IN2014KN02847A (enExample) | 2015-05-08 |
| CN104470428B (zh) | 2018-09-11 |
| AU2013264992B2 (en) | 2017-03-16 |
| EP2852323A1 (en) | 2015-04-01 |
| WO2013175196A1 (en) | 2013-11-28 |
| JP2015520646A (ja) | 2015-07-23 |
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