ES259408A1 - Improved tetracycline antibiotic compositions - Google Patents

Improved tetracycline antibiotic compositions

Info

Publication number
ES259408A1
ES259408A1 ES0259408A ES259408A ES259408A1 ES 259408 A1 ES259408 A1 ES 259408A1 ES 0259408 A ES0259408 A ES 0259408A ES 259408 A ES259408 A ES 259408A ES 259408 A1 ES259408 A1 ES 259408A1
Authority
ES
Spain
Prior art keywords
compounds
acid
radical
alkyl
hydroxycarboxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0259408A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES259408A1 publication Critical patent/ES259408A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/40—Separation, e.g. from natural material; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pharmaceutical and veterinary compositions comprise a tetracycline antibiotic (many examples being given) and an adjuvant compound selected from pyromellitic acid trimellitic acid-1,2-anhydride rhodizonic acid disodium 2,3-pyrazine disulphonate 2-naphthol-8-sulphonic acid 1 - naphthol - 4 - sulphonic acid salicylaldehyde compounds of the general formula <FORM:0905092/VI/1> wherein R1 and R2 are the same and may be hydroxycarboxy lower (C1-6) alkyl or alkyl radicals or R1 is hydroxy and R2 is a hydroxycarboxy lower alkyl, phenyl, xylyl or benzyl radical or R1 is the potassium salt of a hydroxy radical and R2 is the phthalic radical or R1 is hydrogen and R2 is hexahydrohexyl tri-(2-carboxyethyl) phosphine hydrochloride and bis-(2-carboxyethy) phenyl phosphine oxide and simple salts of these compounds not already in simple salt form and salts with tetracycline compounds. The compositions may be in conventional forms suitable for oral and parenteral administration including mixtures with animal feedstuffs.
ES0259408A 1959-07-10 1960-07-04 Improved tetracycline antibiotic compositions Expired ES259408A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82611059A 1959-07-10 1959-07-10

Publications (1)

Publication Number Publication Date
ES259408A1 true ES259408A1 (en) 1960-12-16

Family

ID=25245736

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0259408A Expired ES259408A1 (en) 1959-07-10 1960-07-04 Improved tetracycline antibiotic compositions

Country Status (6)

Country Link
BE (1) BE592795A (en)
ES (1) ES259408A1 (en)
FR (1) FR17M (en)
GB (1) GB905092A (en)
GT (1) GT196000211A (en)
LU (1) LU38938A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU541247B2 (en) * 1979-12-20 1985-01-03 R.P. Scherer Corporation Adjuvants for rectal delivery of drug substances
NZ196349A (en) * 1980-03-07 1984-08-24 Interx Research Corp Enhancement of absorption rate of orally administered polar bioactive agents

Also Published As

Publication number Publication date
BE592795A (en) 1960-10-31
GB905092A (en) 1962-09-05
GT196000211A (en) 1961-12-30
LU38938A1 (en) 1960-10-12
FR17M (en) 1961-01-06

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