ES8202003A1 - Ergoline derivatives, process for their preparation, and pharmaceutical compositions - Google Patents

Ergoline derivatives, process for their preparation, and pharmaceutical compositions

Info

Publication number
ES8202003A1
ES8202003A1 ES500911A ES500911A ES8202003A1 ES 8202003 A1 ES8202003 A1 ES 8202003A1 ES 500911 A ES500911 A ES 500911A ES 500911 A ES500911 A ES 500911A ES 8202003 A1 ES8202003 A1 ES 8202003A1
Authority
ES
Spain
Prior art keywords
atoms
compounds
pharmaceutical compositions
group
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500911A
Other languages
Spanish (es)
Other versions
ES500911A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of ES8202003A1 publication Critical patent/ES8202003A1/en
Publication of ES500911A0 publication Critical patent/ES500911A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides

Abstract

The invention relates to compounds of the general formula < IMAGE > in which R1 denotes hydrogen or methyl R2 represents hydrogen, halogen, methyl, formyl or a group of the formula S-R7 or SO-R7, where R7 is alkyl having 1 to 4 C atoms or phenyl R3 denotes hydrogen or methoxy R4 is a hydrocarbon group having 1 to 4 C atoms, benzyl or phenethyl and R5 and R6 independently of one another in each case represent alkyl having 1 to 4 C atoms, cyclohexyl or optionally substituted phenyl or an acid- and water-soluble group, such as (CH2)nN(CH3)2, where n is an integer, with the proviso that R5 and R6 do not simultaneously denote the acid- and water-soluble group, and their pharmaceutically acceptable acid addition salts with organic or inorganic acids, which can be used as antihypertensive agents and exhibit both antiprolactin activity and an activity against tumours. A process whereby the abovementioned compounds are prepared from carboxyergolines and carbodiimides, and pharmaceutical compositions which contain these compounds, are additionally described.
ES500911A 1980-04-03 1981-03-31 A PROCEDURE FOR THE PREPARATION OF ERGOLI-NA DERIVATIVES Granted ES500911A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8011234 1980-04-03
GB8040575 1980-12-18

Publications (2)

Publication Number Publication Date
ES8202003A1 true ES8202003A1 (en) 1982-01-16
ES500911A0 ES500911A0 (en) 1982-01-16

Family

ID=26275073

Family Applications (1)

Application Number Title Priority Date Filing Date
ES500911A Granted ES500911A0 (en) 1980-04-03 1981-03-31 A PROCEDURE FOR THE PREPARATION OF ERGOLI-NA DERIVATIVES

Country Status (20)

Country Link
AT (1) AT375076B (en)
AU (1) AU540621B2 (en)
CA (1) CA1156648A (en)
CH (1) CH645896A5 (en)
CS (1) CS415291A3 (en)
DE (1) DE3112861A1 (en)
DK (1) DK148686C (en)
ES (1) ES500911A0 (en)
FI (1) FI70412C (en)
FR (1) FR2479829B1 (en)
GR (1) GR74806B (en)
HK (1) HK67287A (en)
IE (1) IE51130B1 (en)
IL (1) IL62519A (en)
IT (2) IT1210473B (en)
NL (3) NL189462C (en)
NZ (1) NZ196670A (en)
PT (1) PT72785B (en)
SE (1) SE442637B (en)
YU (1) YU43011B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2173189B (en) * 1985-02-21 1988-04-27 Maruko Pharmaceutical Co Ergoline derivatives and salts thereof and pharmaceutical compositions thereof
GB0409785D0 (en) 2004-04-30 2004-06-09 Resolution Chemicals Ltd Preparation of cabergoline
US7339060B2 (en) 2005-03-23 2008-03-04 Resolution Chemicals, Ltd. Preparation of cabergoline
GB0505965D0 (en) 2005-03-23 2005-04-27 Resolution Chemicals Ltd Preparation of cabergoline
US7939665B2 (en) 2007-05-04 2011-05-10 Apotex Pharmachem Inc. Efficient process for the preparation of cabergoline and its intermediates
EP2067780A1 (en) * 2007-12-07 2009-06-10 Axxonis Pharma AG Ergoline derivatives as selective radical scavengers for neurons

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE396753B (en) * 1970-05-18 1977-10-03 Richter Gedeon Vegyeszet ANALOGICAL PROCEDURE FOR PREPARING AN ASSOCIATION OF THE DIHYDROLYSERG ACID SERIES

Also Published As

Publication number Publication date
FI70412B (en) 1986-03-27
IE810754L (en) 1981-10-03
DK148686B (en) 1985-09-02
IL62519A0 (en) 1981-05-20
NL189462B (en) 1992-11-16
YU85181A (en) 1984-02-29
IT8120866A0 (en) 1981-04-01
IL62519A (en) 1984-01-31
AT375076B (en) 1984-06-25
NL189462C (en) 1993-04-16
DE3112861C2 (en) 1989-06-01
ATA148481A (en) 1983-11-15
HK67287A (en) 1987-09-25
YU43011B (en) 1989-02-28
SE8102131L (en) 1981-10-04
NL930091I1 (en) 1993-10-01
PT72785A (en) 1981-05-01
NL930091I2 (en) 1995-01-02
NL8101509A (en) 1981-11-02
FR2479829B1 (en) 1987-07-24
NZ196670A (en) 1982-12-07
FI70412C (en) 1986-09-19
FR2479829A1 (en) 1981-10-09
CA1156648A (en) 1983-11-08
DE3112861A1 (en) 1982-01-07
IT8120865A0 (en) 1981-04-01
FI811025L (en) 1981-10-04
IT1205241B (en) 1989-03-15
ES500911A0 (en) 1982-01-16
DK150781A (en) 1981-10-04
AU6893781A (en) 1981-10-08
DK148686C (en) 1986-03-10
PT72785B (en) 1982-07-26
GR74806B (en) 1984-07-12
SE442637B (en) 1986-01-20
IE51130B1 (en) 1986-10-15
CS415291A3 (en) 1992-06-17
NL930092I1 (en) 1993-10-01
CH645896A5 (en) 1984-10-31
AU540621B2 (en) 1984-11-29
IT1210473B (en) 1989-09-14

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Legal Events

Date Code Title Description
PC1A Transfer granted