ES2592204T3 - Vacunas mejoradas para el virus del papiloma humano y métodos para usarlas - Google Patents
Vacunas mejoradas para el virus del papiloma humano y métodos para usarlas Download PDFInfo
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- ES2592204T3 ES2592204T3 ES10733940.0T ES10733940T ES2592204T3 ES 2592204 T3 ES2592204 T3 ES 2592204T3 ES 10733940 T ES10733940 T ES 10733940T ES 2592204 T3 ES2592204 T3 ES 2592204T3
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| US8298820B2 (en) | 2010-01-26 | 2012-10-30 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
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| EP2836505B1 (en) * | 2012-04-10 | 2019-01-23 | The Trustees Of The University Of Pennsylvania | Human respiratory syncytial virus concensus antigens, nucleic acid constructs and vaccines made thereform, and methods of using same |
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| US5338683A (en) * | 1981-12-24 | 1994-08-16 | Health Research Incorporated | Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins |
| US4510245A (en) * | 1982-11-18 | 1985-04-09 | Chiron Corporation | Adenovirus promoter system |
| ZA858044B (en) * | 1984-11-01 | 1987-05-27 | American Home Prod | Oral vaccines |
| US5643579A (en) * | 1984-11-01 | 1997-07-01 | American Home Products Corporation | Oral vaccines |
| US5036006A (en) * | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US4945050A (en) * | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US4797368A (en) * | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| GB8508845D0 (en) * | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
| US5223424A (en) * | 1985-09-06 | 1993-06-29 | Prutech Research And Development | Attenuated herpesviruses and herpesviruses which include foreign DNA encoding an amino acid sequence |
| US4790987A (en) * | 1985-11-15 | 1988-12-13 | Research Corporation | Viral glycoprotein subunit vaccine |
| US5310668A (en) * | 1986-06-20 | 1994-05-10 | Merck & Co., Inc. | Varicella-zoster virus as a live recombinant vaccine |
| US5242829A (en) * | 1986-09-23 | 1993-09-07 | Therion Biologics Corporation | Recombinant pseudorabies virus |
| US5387744A (en) * | 1987-06-04 | 1995-02-07 | Washington University | Avirulent microbes and uses therefor: Salmonella typhi |
| US5294441A (en) * | 1987-06-04 | 1994-03-15 | Washington University | Avirulent microbes and uses therefor: salmonella typhi |
| IL86583A0 (en) * | 1987-06-04 | 1988-11-15 | Molecular Eng Ass | Vaccine containing a derivative of a microbe and method for the production thereof |
| US5112749A (en) * | 1987-10-02 | 1992-05-12 | Praxis Biologics, Inc. | Vaccines for the malaria circumsporozoite protein |
| CH682669A5 (fr) * | 1989-03-08 | 1993-10-29 | Health Research Inc | Virus recombinant modifié pour exprimer un produit de gènes chez un hôte, procédés et vaccin correspondants. |
| US5225336A (en) * | 1989-03-08 | 1993-07-06 | Health Research Incorporated | Recombinant poxvirus host range selection system |
| US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5591439A (en) * | 1989-03-24 | 1997-01-07 | The Wistar Institute Of Anatomy And Biology | Recombinant cytomegalovirus vaccine |
| JP3004049B2 (ja) * | 1989-03-31 | 2000-01-31 | ワシントン ユニバーシティー | 病原性のないphoP型微生物を含有するワクチン |
| DE69016956T2 (de) * | 1989-12-04 | 1995-07-20 | Akzo Nobel Nv | Rekombinantes Truthahn-Herpesvirus und davon abgeleiteter Lebendimpfstoffvektor. |
| US5294548A (en) * | 1990-04-02 | 1994-03-15 | American Biogenetic Sciences, Inc | Recombianant Hepatitis a virus |
| AU7906691A (en) * | 1990-05-23 | 1991-12-10 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Adeno-associated virus (aav)-based eucaryotic vectors |
| US5462734A (en) * | 1990-11-02 | 1995-10-31 | Wisconsin Alumni Research Foundation | Bovine herpesvirus vaccine and method of using same |
| US5240703A (en) * | 1991-03-01 | 1993-08-31 | Syntro Corporation | Attenuated, genetically-engineered pseudorabies virus s-prv-155 and uses thereof |
| US6034298A (en) * | 1991-08-26 | 2000-03-07 | Prodigene, Inc. | Vaccines expressed in plants |
| US5955088A (en) * | 1992-02-03 | 1999-09-21 | Cedars-Sinai Medical Center | Pharmaceutical compsition of herpes simplex virus type-1 (HSV-1), glycoproteins |
| US5981505A (en) * | 1993-01-26 | 1999-11-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of genetic material |
| DE69434469T2 (de) | 1993-01-26 | 2006-06-14 | Univ Pennsylvania | Zusammensetzungen und verfahren zur verabreichung von genetischem material |
| US5593972A (en) * | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| EP0708659A4 (en) * | 1993-06-07 | 2000-08-23 | Genentech Inc | HIV ENVELOPE POLYPEPTIDE |
| US5739118A (en) * | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| US6156319A (en) * | 1994-07-25 | 2000-12-05 | The Trustees Of The University Of Pennsylvania | Soluble herpesvirus glycoprotein complex vaccine |
| NL9401820A (nl) * | 1994-11-02 | 1996-06-03 | Meyn Maschf | Inrichting voor het bewerken van aan zijn poten opgehangen gevogelte. |
| US5962428A (en) * | 1995-03-30 | 1999-10-05 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| US5650309A (en) * | 1995-05-16 | 1997-07-22 | The Regents Of The University Of California | Viral vectors |
| US5698202A (en) * | 1995-06-05 | 1997-12-16 | The Wistar Institute Of Anatomy & Biology | Replication-defective adenovirus human type 5 recombinant as a rabies vaccine carrier |
| AUPN443995A0 (en) * | 1995-07-27 | 1995-08-17 | Csl Limited | Papillomavirus polyprotein |
| GB9717953D0 (en) * | 1997-08-22 | 1997-10-29 | Smithkline Beecham Biolog | Vaccine |
| GB9727262D0 (en) * | 1997-12-24 | 1998-02-25 | Smithkline Beecham Biolog | Vaccine |
| US20050031638A1 (en) * | 1997-12-24 | 2005-02-10 | Smithkline Beecham Biologicals S.A. | Vaccine |
| US6589529B1 (en) * | 1998-10-30 | 2003-07-08 | Children's Hospital Medical Center | Rotavirus subunit vaccine |
| US8209006B2 (en) * | 2002-03-07 | 2012-06-26 | Vgx Pharmaceuticals, Inc. | Constant current electroporation device and methods of use |
| US7245963B2 (en) * | 2002-03-07 | 2007-07-17 | Advisys, Inc. | Electrode assembly for constant-current electroporation and use |
| WO2005033333A2 (en) * | 2003-10-07 | 2005-04-14 | Dako Denmark A/S | Methods and compositions for the diagnosis of cancer |
| JP5345053B2 (ja) | 2006-04-19 | 2013-11-20 | 浦項工科大學校 産學協力團 | 子宮頸癌の予防及び治療のためのヒトパピローマウイルスポリペプチドと免疫増強剤を含む組成物 |
| JP2009534331A (ja) | 2006-04-21 | 2009-09-24 | トランジェーヌ、ソシエテ、アノニム | Hpv‐18を主体とするパピローマウイルスワクチン |
| CN101679475B (zh) | 2006-07-28 | 2015-08-12 | 宾夕法尼亚大学托管会 | 改进的疫苗及其使用方法 |
| KR20140137679A (ko) | 2013-05-23 | 2014-12-03 | 삼성전자주식회사 | 카드 소켓 장치 |
-
2009
- 2009-01-30 CA CA2653478A patent/CA2653478A1/en not_active Abandoned
-
2010
- 2010-01-21 US US12/691,588 patent/US8389706B2/en active Active
- 2010-01-22 CN CN2010800055837A patent/CN102292089A/zh active Pending
- 2010-01-22 ES ES10733940.0T patent/ES2592204T3/es active Active
- 2010-01-22 AU AU2010206611A patent/AU2010206611B2/en active Active
- 2010-01-22 PL PL10733940T patent/PL2393496T3/pl unknown
- 2010-01-22 JP JP2011548155A patent/JP5996191B2/ja active Active
- 2010-01-22 EP EP10733940.0A patent/EP2393496B1/en active Active
- 2010-01-22 EA EA201170965A patent/EA023892B1/ru not_active IP Right Cessation
- 2010-01-22 CA CA2749120A patent/CA2749120C/en active Active
- 2010-01-22 PT PT107339400T patent/PT2393496T/pt unknown
- 2010-01-22 CN CN201710280349.9A patent/CN107267530A/zh active Pending
- 2010-01-22 WO PCT/US2010/021869 patent/WO2010085697A1/en not_active Ceased
- 2010-01-22 KR KR1020117017259A patent/KR101652764B1/ko active Active
- 2010-01-22 MX MX2011007692A patent/MX2011007692A/es active IP Right Grant
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2015
- 2015-07-31 JP JP2015151495A patent/JP2015192673A/ja not_active Withdrawn
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2018
- 2018-04-17 HK HK18104980.4A patent/HK1245334A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5996191B2 (ja) | 2016-09-21 |
| WO2010085697A1 (en) | 2010-07-29 |
| EP2393496A1 (en) | 2011-12-14 |
| US20100189730A1 (en) | 2010-07-29 |
| CN107267530A (zh) | 2017-10-20 |
| AU2010206611B2 (en) | 2015-09-17 |
| PT2393496T (pt) | 2016-11-10 |
| CA2653478A1 (en) | 2010-07-23 |
| JP2015192673A (ja) | 2015-11-05 |
| KR20110106901A (ko) | 2011-09-29 |
| EA201170965A1 (ru) | 2012-01-30 |
| CA2749120C (en) | 2019-09-17 |
| CA2749120A1 (en) | 2010-07-29 |
| JP2012515557A (ja) | 2012-07-12 |
| EA023892B1 (ru) | 2016-07-29 |
| EP2393496A4 (en) | 2012-08-29 |
| US8389706B2 (en) | 2013-03-05 |
| AU2010206611A1 (en) | 2011-07-21 |
| MX2011007692A (es) | 2011-08-12 |
| EP2393496B1 (en) | 2016-08-03 |
| HK1245334A1 (zh) | 2018-08-24 |
| PL2393496T3 (pl) | 2017-02-28 |
| KR101652764B1 (ko) | 2016-08-31 |
| CN102292089A (zh) | 2011-12-21 |
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