ES2588010T3 - Polipéptidos de Yersinia spp. y métodos de uso - Google Patents
Polipéptidos de Yersinia spp. y métodos de uso Download PDFInfo
- Publication number
- ES2588010T3 ES2588010T3 ES06719369.8T ES06719369T ES2588010T3 ES 2588010 T3 ES2588010 T3 ES 2588010T3 ES 06719369 T ES06719369 T ES 06719369T ES 2588010 T3 ES2588010 T3 ES 2588010T3
- Authority
- ES
- Spain
- Prior art keywords
- seq
- kda
- polypeptides
- polypeptide
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract description 123
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract description 119
- 229920001184 polypeptide Polymers 0.000 title abstract description 118
- 238000000034 method Methods 0.000 title abstract description 11
- 241000607734 Yersinia <bacteria> Species 0.000 title description 12
- 239000000203 mixture Substances 0.000 abstract description 45
- 241000607447 Yersinia enterocolitica Species 0.000 abstract description 32
- 229940098232 yersinia enterocolitica Drugs 0.000 abstract description 12
- 102000004169 proteins and genes Human genes 0.000 abstract description 10
- 108090000623 proteins and genes Proteins 0.000 abstract description 10
- 238000002360 preparation method Methods 0.000 abstract description 6
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical group N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 abstract description 4
- 239000003599 detergent Substances 0.000 abstract description 4
- 210000000170 cell membrane Anatomy 0.000 abstract description 3
- 241000607479 Yersinia pestis Species 0.000 description 29
- OEUUFNIKLCFNLN-LLVKDONJSA-N chembl432481 Chemical compound OC(=O)[C@@]1(C)CSC(C=2C(=CC(O)=CC=2)O)=N1 OEUUFNIKLCFNLN-LLVKDONJSA-N 0.000 description 21
- 239000012634 fragment Substances 0.000 description 17
- 230000003647 oxidation Effects 0.000 description 11
- 238000007254 oxidation reaction Methods 0.000 description 11
- 238000001962 electrophoresis Methods 0.000 description 8
- 239000002609 medium Substances 0.000 description 8
- 229920002401 polyacrylamide Polymers 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 6
- 229910052708 sodium Inorganic materials 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 4
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 4
- 229930182817 methionine Natural products 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 102000004142 Trypsin Human genes 0.000 description 3
- 108090000631 Trypsin Proteins 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- 230000002163 immunogen Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 239000012588 trypsin Substances 0.000 description 3
- 239000001974 tryptic soy broth Substances 0.000 description 3
- 108010050327 trypticase-soy broth Proteins 0.000 description 3
- 241000251468 Actinopterygii Species 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 102100034392 Trypsin-2 Human genes 0.000 description 2
- 101710119666 Trypsin-2 Proteins 0.000 description 2
- 241001148129 Yersinia ruckeri Species 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 102000006240 membrane receptors Human genes 0.000 description 2
- 108020004084 membrane receptors Proteins 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 102000006303 Chaperonin 60 Human genes 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 241000588921 Enterobacteriaceae Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 102000007390 Glycogen Phosphorylase Human genes 0.000 description 1
- 108010046163 Glycogen Phosphorylase Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 108090000862 Ion Channels Proteins 0.000 description 1
- 102000004310 Ion Channels Human genes 0.000 description 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
- 101710137186 LPS-assembly protein LptD Proteins 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 101710168275 Outer membrane protein X Proteins 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000010562 Peptide Elongation Factor G Human genes 0.000 description 1
- 108010077742 Peptide Elongation Factor G Proteins 0.000 description 1
- 102000008153 Peptide Elongation Factor Tu Human genes 0.000 description 1
- 108010049977 Peptide Elongation Factor Tu Proteins 0.000 description 1
- 206010035148 Plague Diseases 0.000 description 1
- 108010013381 Porins Proteins 0.000 description 1
- 102000017033 Porins Human genes 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 241000607477 Yersinia pseudotuberculosis Species 0.000 description 1
- 208000025087 Yersinia pseudotuberculosis infectious disease Diseases 0.000 description 1
- JHYVWAMMAMCUIR-UHFFFAOYSA-N Yersiniabactin Natural products CC(C)(C(O)C1CSC(N1)C1CSC(=N1)c1ccccc1O)C1=NC(C)(CS1)C(O)=O JHYVWAMMAMCUIR-UHFFFAOYSA-N 0.000 description 1
- 108010081577 aldehyde dehydrogenase (NAD(P)+) Proteins 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 229940043264 dodecyl sulfate Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 108010037896 heparin-binding hemagglutinin Proteins 0.000 description 1
- 230000004957 immunoregulator effect Effects 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 108010089727 siderophore receptors Proteins 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- JHYVWAMMAMCUIR-VQNLDRKJSA-N yersiniabactin Chemical compound C([C@@H](N=1)C2SC[C@H](N2)[C@@H](O)C(C)(C)C=2SC[C@@](C)(N=2)C(O)=O)SC=1C1=CC=CC=C1O JHYVWAMMAMCUIR-VQNLDRKJSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0291—Yersinia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64610605P | 2005-01-21 | 2005-01-21 | |
| US646106P | 2005-01-21 | ||
| PCT/US2006/002474 WO2006079076A2 (en) | 2005-01-21 | 2006-01-20 | Yersinia spp. polypeptides and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2588010T3 true ES2588010T3 (es) | 2016-10-28 |
Family
ID=36649588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06719369.8T Active ES2588010T3 (es) | 2005-01-21 | 2006-01-20 | Polipéptidos de Yersinia spp. y métodos de uso |
Country Status (12)
| Country | Link |
|---|---|
| US (8) | US8563004B2 (enExample) |
| EP (3) | EP1848732B1 (enExample) |
| JP (3) | JP2008528512A (enExample) |
| CN (1) | CN101142230A (enExample) |
| AU (1) | AU2006206234B2 (enExample) |
| BR (1) | BRPI0606506A2 (enExample) |
| CA (1) | CA2595163A1 (enExample) |
| DK (1) | DK1848732T3 (enExample) |
| ES (1) | ES2588010T3 (enExample) |
| MX (1) | MX2007008723A (enExample) |
| NZ (1) | NZ556651A (enExample) |
| WO (1) | WO2006079076A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5830479A (en) * | 1994-02-09 | 1998-11-03 | Willmar Poultry Company, Inc. | Active immunization using a siderophore receptor protein |
| ES2279511T3 (es) * | 1994-02-09 | 2007-08-16 | Epitopix Llc | Inmunizacion activa utilizando una proteina receptor de sideroforo. |
| MXPA03006038A (es) * | 2001-01-03 | 2005-02-14 | Willmar Poultry Co Inc | Composiciones inmunizantes y metodos de uso. |
| US8119147B2 (en) | 2003-09-19 | 2012-02-21 | Epitopix, Llc | Compositions produced using enteric pathogens and methods of use |
| JP2008528512A (ja) | 2005-01-21 | 2008-07-31 | エピトピックス，リミティド ライアビリティ カンパニー | エルシニアｓｐｐ．ポリペプチド及び使用方法 |
| CN107325165A (zh) | 2011-05-31 | 2017-11-07 | 和黄生物膜医疗解决方案有限公司 | 细胞聚集体的分散和脱离 |
| US9631221B1 (en) * | 2011-09-02 | 2017-04-25 | Becton, Dickinson And Company | Identification of microorganisms using MALDI-TOF-MS on-plate extraction |
| KR101948400B1 (ko) * | 2011-12-29 | 2019-02-14 | 타오 헬스 라이프 파마 가부시키가이샤 | 아밀로스페로이드가 결합하여 성숙 신경 세포사를 유발하는 표적 분자, 아밀로스페로이드가 유도하는 신경 세포사를 억제하는 방법 및 물질, 및 그들의 이용 |
| JP6141205B2 (ja) * | 2012-02-13 | 2017-06-07 | 国立大学法人京都工芸繊維大学 | 窒化ケイ素（Ｓｉ３Ｎ４）親和性ペプチド、及びその利用 |
| US8753643B1 (en) | 2012-04-11 | 2014-06-17 | Life-Science Innovations, Llc | Spray dried compositions and methods of use |
| US9017953B2 (en) * | 2012-05-18 | 2015-04-28 | Washington University | Biomarker and therapeutic for urinary tract infection |
| RU2549712C1 (ru) * | 2013-11-26 | 2015-04-27 | Федеральное казенное учреждение здравоохранения "Ростовский-на-Дону ордена Трудового Красного Знамени научно-исследовательский противочумный институт" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека | CПОСОБ ВЫДЕЛЕНИЯ ИНГИБИТОРА СЕКРЕЦИИ СИДЕРОФОРОВ, СИНТЕЗИРУЕМОГО pgm- ШТАММАМИ Y. pestis И ВЫДЕЛЕННЫЙ ИНГИБИТОР |
| FR3024903A1 (fr) | 2014-08-14 | 2016-02-19 | Biomerieux Sa | Procede de quantification d'au moins un groupe de microorganismes par spectrometrie de masse |
| AU2015329723A1 (en) * | 2014-10-10 | 2017-04-27 | Rare Element Resources, Ltd. | Processing for the extraction of rare earth elements |
| IL308212A (en) | 2015-01-20 | 2024-01-01 | Igm Biosciences Inc | Tumor necrosis factor-α receptor binding molecules and their uses |
| US11235049B2 (en) | 2015-11-09 | 2022-02-01 | Epitopix, Llc | Polypeptides of fusobacterium and methods of use |
| US10166280B2 (en) | 2016-06-08 | 2019-01-01 | Epitopix, Llc | Polypeptides and immunizing compositions containing Bacillus polypeptides and methods of use |
| JP7183168B2 (ja) | 2017-02-10 | 2022-12-05 | エピトピックス， エルエルシー | タンパク質、及びＰａｓｔｅｕｒｅｌｌａタンパク質を含有する免疫化組成物、ならびに使用方法 |
| EP4045087A4 (en) | 2019-10-18 | 2024-03-27 | University of Utah Research Foundation | Polymeric drug delivery conjugates and methods of making and using thereof |
| CN113679829B (zh) * | 2020-05-18 | 2024-01-02 | 北京繁易纳维科技有限公司 | 一种预防癌症术后复发的肿瘤疫苗及其制备方法和应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5420253A (en) | 1993-09-09 | 1995-05-30 | Willmar Poultry Company, Inc. | Method for purifying egg yolk immunoglobulins |
| US5830479A (en) | 1994-02-09 | 1998-11-03 | Willmar Poultry Company, Inc. | Active immunization using a siderophore receptor protein |
| ES2279511T3 (es) | 1994-02-09 | 2007-08-16 | Epitopix Llc | Inmunizacion activa utilizando una proteina receptor de sideroforo. |
| WO1995025742A1 (en) | 1994-03-22 | 1995-09-28 | Pfizer Inc. | Pasteurellaceae antigens and related vaccines |
| US5538733A (en) | 1994-07-07 | 1996-07-23 | Willmar Poultry Company, Inc. | Method of priming an immune response in a one-day old animal |
| AU5597998A (en) * | 1996-12-04 | 1998-06-29 | Heska Corporation | Recombinant plague vaccine |
| US6248329B1 (en) * | 1998-06-01 | 2001-06-19 | Ramaswamy Chandrashekar | Parasitic helminth cuticlin nucleic acid molecules and uses thereof |
| US6610836B1 (en) | 1999-01-29 | 2003-08-26 | Genome Therapeutics Corporation | Nucleic acid amino acid sequences relating to Klebsiella pneumoniae for diagnostics and therapeutics |
| US6682754B2 (en) | 1999-11-24 | 2004-01-27 | Willmar Poultry Company, Inc. | Ovo delivery of an immunogen containing implant |
| WO2001070955A2 (en) | 2000-03-21 | 2001-09-27 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in prokaryotes |
| MXPA03006038A (es) | 2001-01-03 | 2005-02-14 | Willmar Poultry Co Inc | Composiciones inmunizantes y metodos de uso. |
| AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
| GB0127657D0 (en) * | 2001-11-19 | 2002-01-09 | Microscience Ltd | Virulence genes and proteins and their use |
| DE20321889U1 (de) * | 2002-08-02 | 2012-03-12 | Glaxosmithkline Biologicals S.A. | Impfstoffzusammensetzung |
| US8119147B2 (en) | 2003-09-19 | 2012-02-21 | Epitopix, Llc | Compositions produced using enteric pathogens and methods of use |
| ATE493437T1 (de) | 2004-07-23 | 2011-01-15 | Novartis Vaccines & Diagnostic | Polypeptide für die oligomerisierung von antigenen |
| EP1784417B1 (en) | 2004-08-25 | 2016-05-18 | Epitopix, LLC | Fusobacterium polypeptides and methods of use |
| JP2008528512A (ja) | 2005-01-21 | 2008-07-31 | エピトピックス，リミティド ライアビリティ カンパニー | エルシニアｓｐｐ．ポリペプチド及び使用方法 |
| NZ560929A (en) * | 2005-02-18 | 2009-12-24 | Novartis Vaccines & Diagnostic | Immunogens from uropathogenic escherichia coli |
| WO2006113907A2 (en) * | 2005-04-20 | 2006-10-26 | The General Hospital Corporation | Escherichia coli o157:h7 proteins and uses thereof |
-
2006
- 2006-01-20 JP JP2007552375A patent/JP2008528512A/ja not_active Withdrawn
- 2006-01-20 ES ES06719369.8T patent/ES2588010T3/es active Active
- 2006-01-20 EP EP06719369.8A patent/EP1848732B1/en active Active
- 2006-01-20 EP EP11007570A patent/EP2431382A1/en not_active Withdrawn
- 2006-01-20 US US11/336,706 patent/US8563004B2/en active Active
- 2006-01-20 BR BRPI0606506-6A patent/BRPI0606506A2/pt not_active Application Discontinuation
- 2006-01-20 WO PCT/US2006/002474 patent/WO2006079076A2/en not_active Ceased
- 2006-01-20 MX MX2007008723A patent/MX2007008723A/es active IP Right Grant
- 2006-01-20 AU AU2006206234A patent/AU2006206234B2/en not_active Ceased
- 2006-01-20 NZ NZ556651A patent/NZ556651A/en not_active IP Right Cessation
- 2006-01-20 DK DK06719369.8T patent/DK1848732T3/en active
- 2006-01-20 CA CA002595163A patent/CA2595163A1/en not_active Abandoned
- 2006-01-20 EP EP11075020A patent/EP2361926A3/en not_active Withdrawn
- 2006-01-20 CN CNA2006800028566A patent/CN101142230A/zh active Pending
-
2011
- 2011-01-31 US US13/018,292 patent/US20110206674A1/en not_active Abandoned
-
2012
- 2012-09-24 JP JP2012209231A patent/JP6178059B2/ja active Active
-
2013
- 2013-10-08 US US14/048,640 patent/US9085612B2/en active Active
- 2013-10-08 US US14/048,649 patent/US9085613B2/en active Active
- 2013-10-08 US US14/048,643 patent/US9109018B2/en active Active
-
2015
- 2015-07-07 US US14/793,494 patent/US9221899B2/en active Active
- 2015-07-10 JP JP2015139060A patent/JP6224655B2/ja active Active
- 2015-11-05 US US14/933,899 patent/US9352029B2/en active Active
-
2016
- 2016-04-28 US US15/140,767 patent/US9801932B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2588010T3 (es) | Polipéptidos de Yersinia spp. y métodos de uso | |
| Walton | The cyclic peptide toxins of amanitaand other poisonous mushrooms | |
| Conlon et al. | Isolation of peptides of the brevinin‐1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii | |
| Vialás et al. | Cell surface shaving of C andida albicans biofilms, hyphae, and yeast form cells | |
| Pastorino et al. | Identification of cellular proteome modifications in response to West Nile virus infection | |
| Wasinpiyamongkol et al. | Blood‐feeding and immunogenic Aedes aegypti saliva proteins | |
| FR2794865A1 (fr) | Methode de detection precoce des flavivirus et ses applications | |
| Wang et al. | A novel protein isolated from the serum of rabbitfish (Siganus oramin) is lethal to Cryptocaryon irritans | |
| CN106421772A (zh) | 新的人轮状病毒株和疫苗 | |
| Orsborn et al. | Protein expression profiling of Coccidioides posadasii by two-dimensional differential in-gel electrophoresis and evaluation of a newly recognized peroxisomal matrix protein as a recombinant vaccine candidate | |
| CN106810602A (zh) | 弓形虫感染小鼠脑组织差异表达蛋白质、与大脑发育调节蛋白相互作用的蛋白质及其应用 | |
| Piras et al. | Identification of immunoreactive proteins of Mycobacterium avium subsp. paratuberculosis | |
| Almeras et al. | Salivary gland protein repertoire from Aedes aegypti mosquitoes | |
| Hernychova et al. | Detection and identification of Coxiella burnetii based on the mass spectrometric analyses of the extracted proteins | |
| Tan et al. | Involvement of Urm1, a ubiquitin-like protein, in the regulation of oxidative stress response of toxoplasma gondii | |
| Hernández-González et al. | Proteomic analysis of in vitro newly excysted juveniles from Fasciola hepatica | |
| Wüllner et al. | Interspecies comparison of the bacterial response to allicin reveals species‐specific defense strategies | |
| Di Maggio et al. | Comparative proteomics of adult Paragonimus kellicotti excretion/secretion products released in vitro or present in the lung cyst nodule | |
| Cruz-Mirón et al. | Proteomic characterization of the pellicle of Toxoplasma gondii | |
| CN110156875B (zh) | 抗菌肽H5-p5及其制备方法和应用 | |
| Biswas et al. | Infection with Campylobacter jejuni Induces Tyrosine‐Phosphorylated Proteins into INT‐407 Cells | |
| Schreiber et al. | Proteolytic activity of Candida albicans and other yeasts | |
| FR2676068A1 (fr) | Souches recombinantes immunogenes de b. anthracis - compositions immunogenes les contenant. | |
| Haines et al. | The major protein in the midgut of teneral Glossina morsitans morsitans is a molecular chaperone from the endosymbiotic bacterium Wigglesworthia glossinidia | |
| Aivaliotis et al. | Membrane proteome analysis of the green‐sulfur bacterium Chlorobium tepidum |