ES2587507T3 - Fracción de Plectranthus amboinicus con actividad antiartrítica - Google Patents

Fracción de Plectranthus amboinicus con actividad antiartrítica Download PDF

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Publication number
ES2587507T3
ES2587507T3 ES12401234.5T ES12401234T ES2587507T3 ES 2587507 T3 ES2587507 T3 ES 2587507T3 ES 12401234 T ES12401234 T ES 12401234T ES 2587507 T3 ES2587507 T3 ES 2587507T3
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Spain
Prior art keywords
plectranthus amboinicus
fraction
solvent
antiarthritic activity
extract
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Active
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ES12401234.5T
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English (en)
Inventor
Feng-Nien Ko
Jen-Wei Chen
Wen-Ling Yang
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ONENESS BIOTECH Co
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ONENESS BIOTECH Co
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Publication of ES2587507T3 publication Critical patent/ES2587507T3/es
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

Un extracto de Plectranthus amboinicus (Lour.) Spreng con enriquecimiento de la actividad antiartrítica preparado por un procedimiento que comprende los pasos siguientes: (a) extraer Plectranthus amboinicus (Lour.) Spreng con una solución alcohólica para obtener un extracto bruto; (b) eluir el extracto bruto por una cromatografía de fase normal usando hexano como un primer disolvente y hexano/acetato de etilo como un segundo disolvente para obtener un eluato del segundo disolvente.

Description

imagen1
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Tabla 8 Inhibición de diversos extractos a la liberación de IL-5 de PBMCs inducida por PHA
Concentración de la muestra (ug/ml)
Muestra
5 10 20 40
Ejemplo 2_ON-022
155,3 156,0 127,6 78,9
Ejemplo 2_ON-023
168,5 156,7 115,8 37,0
Ejemplo 1_ON-024
147,7 140,8 117,9 37,0
Ejemplo 1_ON-025
183,1 184,5 228,4 109,5
Ejemplo 3_ON-065
140,8 112,3 74,0 37,0
Ejemplo 3_ON-065
54,4 163,7 185,2 58,6
14

Claims (1)

  1. imagen1
ES12401234.5T 2011-11-22 2012-11-20 Fracción de Plectranthus amboinicus con actividad antiartrítica Active ES2587507T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TW100142840 2011-11-22
TW100142840A TWI501772B (zh) 2011-11-22 2011-11-22 具抗關節炎活性的到手香精萃物

Publications (1)

Publication Number Publication Date
ES2587507T3 true ES2587507T3 (es) 2016-10-25

Family

ID=47355988

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12401234.5T Active ES2587507T3 (es) 2011-11-22 2012-11-20 Fracción de Plectranthus amboinicus con actividad antiartrítica

Country Status (7)

Country Link
US (3) US20130131159A1 (es)
EP (1) EP2596798B1 (es)
JP (1) JP6290531B2 (es)
KR (1) KR101759751B1 (es)
CN (1) CN103127215B (es)
ES (1) ES2587507T3 (es)
TW (1) TWI501772B (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI663982B (zh) * 2013-09-03 2019-07-01 合一生技股份有限公司 到手香萃取物用於製備具抗微生物功效組合物之用途
US10390720B2 (en) 2014-07-17 2019-08-27 Medtronic, Inc. Leadless pacing system including sensing extension
US9399140B2 (en) 2014-07-25 2016-07-26 Medtronic, Inc. Atrial contraction detection by a ventricular leadless pacing device for atrio-synchronous ventricular pacing
US10376488B2 (en) * 2014-09-05 2019-08-13 ONENESS BIOTECH CO., Ltd Use of flavonoids in manufacturing compositions for wound healing
US9492668B2 (en) 2014-11-11 2016-11-15 Medtronic, Inc. Mode switching by a ventricular leadless pacing device
US9623234B2 (en) 2014-11-11 2017-04-18 Medtronic, Inc. Leadless pacing device implantation
US9492669B2 (en) 2014-11-11 2016-11-15 Medtronic, Inc. Mode switching by a ventricular leadless pacing device
US9724519B2 (en) 2014-11-11 2017-08-08 Medtronic, Inc. Ventricular leadless pacing device mode switching
US9289612B1 (en) 2014-12-11 2016-03-22 Medtronic Inc. Coordination of ventricular pacing in a leadless pacing system
US11207527B2 (en) 2016-07-06 2021-12-28 Cardiac Pacemakers, Inc. Method and system for determining an atrial contraction timing fiducial in a leadless cardiac pacemaker system
FI3484457T3 (fi) * 2016-07-17 2023-07-07 Oneness Biotech Co Ltd Topikaalinen formulaatio edistämään haavan paranemista
CN107739306B (zh) * 2017-09-11 2021-02-09 湖南鑫利生物科技有限公司 一种制备精制迷迭香提取物的加工方法
EP4362937A1 (en) 2021-06-28 2024-05-08 Oneness Biotech Co., Ltd. Methods for preparation of plectranthus amboinicus extracts
TW202408482A (zh) * 2022-05-27 2024-03-01 合一生技股份有限公司 用於抑制免疫反應的到手香提取物
US11839636B1 (en) * 2022-07-27 2023-12-12 Babry Oren Pharmaceutical composition based on plant raw materials: #2.1

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1781235B1 (en) 2004-07-23 2013-12-25 Wholesome Life Science Co., Ltd. Anti-allergy activities of zingiber zerumbet (l.) smith
CN101632625B (zh) * 2004-08-30 2011-05-11 花王株式会社 皱纹改善剂及皮肤外用组合物
US20070036873A1 (en) 2005-07-27 2007-02-15 Shibnath Ghosal Method of treatment or management of stress
TWI361074B (en) * 2005-12-22 2012-04-01 Dev Center Biotechnology Plant extracts for enhancing healing of wounds,and the preparation process and use thereof
TWI320714B (en) * 2006-09-15 2010-02-21 Dev Center Biotechnology Plant extracts for the treatment of rheumatoid arthritis
EP1925310B1 (en) * 2006-11-24 2015-03-25 Development Center For Biotechnology Plant extracts from Plectranthus and Centella for treating skin disorders and accelerating wound healing in diabetic patients
EP2025340A1 (en) * 2007-08-14 2009-02-18 Development Center For Biotechnology Plant extracts for the treatment of rheumatoid arthritis
JP4606444B2 (ja) * 2007-08-21 2011-01-05 アピ株式会社 アントシアニン含有経口投与用組成物及びその製造方法
US8449924B2 (en) * 2007-08-29 2013-05-28 Development Center For Biotechnology Process for the preparation of plant extracts for treating skin disorders and enhancing healing of wounds
CN101854944A (zh) * 2007-09-17 2010-10-06 梁启铭 以左手香萃取物治疗发炎及发炎相关疾病之组合物及方法
WO2009106125A1 (en) * 2008-02-25 2009-09-03 Nestec S.A. Polyphenols for the treatment of cartilage disorders
JP2011079800A (ja) * 2009-10-09 2011-04-21 Kitasato Institute 抗インフルエンザウイルス剤

Also Published As

Publication number Publication date
CN103127215B (zh) 2017-11-14
US11517604B2 (en) 2022-12-06
TWI501772B (zh) 2015-10-01
KR20130056842A (ko) 2013-05-30
CN103127215A (zh) 2013-06-05
JP2013107888A (ja) 2013-06-06
JP6290531B2 (ja) 2018-03-07
US20170354701A1 (en) 2017-12-14
EP2596798A1 (en) 2013-05-29
EP2596798B1 (en) 2016-06-01
US20140322365A1 (en) 2014-10-30
KR101759751B1 (ko) 2017-07-31
US20130131159A1 (en) 2013-05-23
TW201321010A (zh) 2013-06-01

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