ES2587507T3 - Fracción de Plectranthus amboinicus con actividad antiartrítica - Google Patents
Fracción de Plectranthus amboinicus con actividad antiartrítica Download PDFInfo
- Publication number
- ES2587507T3 ES2587507T3 ES12401234.5T ES12401234T ES2587507T3 ES 2587507 T3 ES2587507 T3 ES 2587507T3 ES 12401234 T ES12401234 T ES 12401234T ES 2587507 T3 ES2587507 T3 ES 2587507T3
- Authority
- ES
- Spain
- Prior art keywords
- plectranthus amboinicus
- fraction
- solvent
- antiarthritic activity
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
Un extracto de Plectranthus amboinicus (Lour.) Spreng con enriquecimiento de la actividad antiartrítica preparado por un procedimiento que comprende los pasos siguientes: (a) extraer Plectranthus amboinicus (Lour.) Spreng con una solución alcohólica para obtener un extracto bruto; (b) eluir el extracto bruto por una cromatografía de fase normal usando hexano como un primer disolvente y hexano/acetato de etilo como un segundo disolvente para obtener un eluato del segundo disolvente.
Description
Tabla 8 Inhibición de diversos extractos a la liberación de IL-5 de PBMCs inducida por PHA
- Concentración de la muestra (ug/ml)
- Muestra
- 5 10 20 40
- Ejemplo 2_ON-022
- 155,3 156,0 127,6 78,9
- Ejemplo 2_ON-023
- 168,5 156,7 115,8 37,0
- Ejemplo 1_ON-024
- 147,7 140,8 117,9 37,0
- Ejemplo 1_ON-025
- 183,1 184,5 228,4 109,5
- Ejemplo 3_ON-065
- 140,8 112,3 74,0 37,0
- Ejemplo 3_ON-065
- 54,4 163,7 185,2 58,6
14
Claims (1)
-
imagen1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TW100142840 | 2011-11-22 | ||
TW100142840A TWI501772B (zh) | 2011-11-22 | 2011-11-22 | 具抗關節炎活性的到手香精萃物 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2587507T3 true ES2587507T3 (es) | 2016-10-25 |
Family
ID=47355988
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES12401234.5T Active ES2587507T3 (es) | 2011-11-22 | 2012-11-20 | Fracción de Plectranthus amboinicus con actividad antiartrítica |
Country Status (7)
Country | Link |
---|---|
US (3) | US20130131159A1 (es) |
EP (1) | EP2596798B1 (es) |
JP (1) | JP6290531B2 (es) |
KR (1) | KR101759751B1 (es) |
CN (1) | CN103127215B (es) |
ES (1) | ES2587507T3 (es) |
TW (1) | TWI501772B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI663982B (zh) * | 2013-09-03 | 2019-07-01 | 合一生技股份有限公司 | 到手香萃取物用於製備具抗微生物功效組合物之用途 |
US10390720B2 (en) | 2014-07-17 | 2019-08-27 | Medtronic, Inc. | Leadless pacing system including sensing extension |
US9399140B2 (en) | 2014-07-25 | 2016-07-26 | Medtronic, Inc. | Atrial contraction detection by a ventricular leadless pacing device for atrio-synchronous ventricular pacing |
US10376488B2 (en) * | 2014-09-05 | 2019-08-13 | ONENESS BIOTECH CO., Ltd | Use of flavonoids in manufacturing compositions for wound healing |
US9492668B2 (en) | 2014-11-11 | 2016-11-15 | Medtronic, Inc. | Mode switching by a ventricular leadless pacing device |
US9623234B2 (en) | 2014-11-11 | 2017-04-18 | Medtronic, Inc. | Leadless pacing device implantation |
US9492669B2 (en) | 2014-11-11 | 2016-11-15 | Medtronic, Inc. | Mode switching by a ventricular leadless pacing device |
US9724519B2 (en) | 2014-11-11 | 2017-08-08 | Medtronic, Inc. | Ventricular leadless pacing device mode switching |
US9289612B1 (en) | 2014-12-11 | 2016-03-22 | Medtronic Inc. | Coordination of ventricular pacing in a leadless pacing system |
US11207527B2 (en) | 2016-07-06 | 2021-12-28 | Cardiac Pacemakers, Inc. | Method and system for determining an atrial contraction timing fiducial in a leadless cardiac pacemaker system |
FI3484457T3 (fi) * | 2016-07-17 | 2023-07-07 | Oneness Biotech Co Ltd | Topikaalinen formulaatio edistämään haavan paranemista |
CN107739306B (zh) * | 2017-09-11 | 2021-02-09 | 湖南鑫利生物科技有限公司 | 一种制备精制迷迭香提取物的加工方法 |
EP4362937A1 (en) | 2021-06-28 | 2024-05-08 | Oneness Biotech Co., Ltd. | Methods for preparation of plectranthus amboinicus extracts |
TW202408482A (zh) * | 2022-05-27 | 2024-03-01 | 合一生技股份有限公司 | 用於抑制免疫反應的到手香提取物 |
US11839636B1 (en) * | 2022-07-27 | 2023-12-12 | Babry Oren | Pharmaceutical composition based on plant raw materials: #2.1 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1781235B1 (en) | 2004-07-23 | 2013-12-25 | Wholesome Life Science Co., Ltd. | Anti-allergy activities of zingiber zerumbet (l.) smith |
CN101632625B (zh) * | 2004-08-30 | 2011-05-11 | 花王株式会社 | 皱纹改善剂及皮肤外用组合物 |
US20070036873A1 (en) | 2005-07-27 | 2007-02-15 | Shibnath Ghosal | Method of treatment or management of stress |
TWI361074B (en) * | 2005-12-22 | 2012-04-01 | Dev Center Biotechnology | Plant extracts for enhancing healing of wounds,and the preparation process and use thereof |
TWI320714B (en) * | 2006-09-15 | 2010-02-21 | Dev Center Biotechnology | Plant extracts for the treatment of rheumatoid arthritis |
EP1925310B1 (en) * | 2006-11-24 | 2015-03-25 | Development Center For Biotechnology | Plant extracts from Plectranthus and Centella for treating skin disorders and accelerating wound healing in diabetic patients |
EP2025340A1 (en) * | 2007-08-14 | 2009-02-18 | Development Center For Biotechnology | Plant extracts for the treatment of rheumatoid arthritis |
JP4606444B2 (ja) * | 2007-08-21 | 2011-01-05 | アピ株式会社 | アントシアニン含有経口投与用組成物及びその製造方法 |
US8449924B2 (en) * | 2007-08-29 | 2013-05-28 | Development Center For Biotechnology | Process for the preparation of plant extracts for treating skin disorders and enhancing healing of wounds |
CN101854944A (zh) * | 2007-09-17 | 2010-10-06 | 梁启铭 | 以左手香萃取物治疗发炎及发炎相关疾病之组合物及方法 |
WO2009106125A1 (en) * | 2008-02-25 | 2009-09-03 | Nestec S.A. | Polyphenols for the treatment of cartilage disorders |
JP2011079800A (ja) * | 2009-10-09 | 2011-04-21 | Kitasato Institute | 抗インフルエンザウイルス剤 |
-
2011
- 2011-11-22 TW TW100142840A patent/TWI501772B/zh active
-
2012
- 2012-04-27 CN CN201210128422.8A patent/CN103127215B/zh active Active
- 2012-11-19 US US13/680,689 patent/US20130131159A1/en not_active Abandoned
- 2012-11-20 ES ES12401234.5T patent/ES2587507T3/es active Active
- 2012-11-20 EP EP12401234.5A patent/EP2596798B1/en active Active
- 2012-11-21 JP JP2012255528A patent/JP6290531B2/ja active Active
- 2012-11-22 KR KR1020120133118A patent/KR101759751B1/ko active IP Right Grant
-
2014
- 2014-07-10 US US14/328,475 patent/US20140322365A1/en not_active Abandoned
-
2017
- 2017-04-25 US US15/496,521 patent/US11517604B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN103127215B (zh) | 2017-11-14 |
US11517604B2 (en) | 2022-12-06 |
TWI501772B (zh) | 2015-10-01 |
KR20130056842A (ko) | 2013-05-30 |
CN103127215A (zh) | 2013-06-05 |
JP2013107888A (ja) | 2013-06-06 |
JP6290531B2 (ja) | 2018-03-07 |
US20170354701A1 (en) | 2017-12-14 |
EP2596798A1 (en) | 2013-05-29 |
EP2596798B1 (en) | 2016-06-01 |
US20140322365A1 (en) | 2014-10-30 |
KR101759751B1 (ko) | 2017-07-31 |
US20130131159A1 (en) | 2013-05-23 |
TW201321010A (zh) | 2013-06-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2587507T3 (es) | Fracción de Plectranthus amboinicus con actividad antiartrítica | |
WO2015134317A8 (en) | Chromatographic materials for the separation of unsaturated molecules | |
ES2691070T3 (es) | Péptidos antiinflamatorios y composición que comprende los mismos | |
ES2693321T3 (es) | Péptidos antiinflamatorios y composición que comprende los mismos | |
ECSP13012668A (es) | Ácidos 1-bencilcicloalquilcarboxílicos sustituidos y su uso | |
WO2012155050A3 (en) | Electromagnetic tracking system and methods of using same | |
CU20140081A7 (es) | Nuevos derivados de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
Wu et al. | In vivo and in vitro anti-inflammatory effects of a novel derivative of icariin | |
BR112016011170A8 (pt) | derivados de heteroaril ácido butanoico, seus usos, combinação e composição farmacêutica | |
CL2010001587A1 (es) | Proceso de preparacion de un concentrado de etil esteres de acidos grasos omega-3 que comprende sobre el 80% en peso de dichos esteres en configuracion cis y sus dobles enlaces separados por una unidad metilenica. | |
JP2011136976A5 (es) | ||
ES2403549R1 (es) | Co-cristales de agomelatina con formadores de co-cristales | |
BR112012019277A2 (pt) | processo para produção de um solvente de acetato de etila e coprodução de etanol | |
WO2012093919A3 (ko) | 백혈병 치료용 조성물 및 몰약 추출물의 제조방법 | |
Yi | Relationship between floral scent of the major nectar source plants and their flower visitors in Changbai Mountain region | |
IN2015CH04779A (es) | ||
RU2012152178A (ru) | Способ получения средства, обладающего антиокислительной и противовоспалительной активностью | |
Zlotnikova | Creative Person and Power: Creator as a Leader | |
MX364272B (es) | PROCESO DE OBTENCION DEL EUDESMANO SESQUITERPENO 4A-CINNAMOILOXI-1ß,3A-DIHIDROXIEUDESM-7,8-ENO(4CDE). | |
Ruina et al. | Active components of Ligustrum lucidum inhibiting hepatitis C virus replicase activity | |
EP2210593A3 (en) | Tablettable formulations of vitamin A and derivatives thereof | |
TH168092A (th) | องค์ประกอบเครื่องสำอางที่ประกอบด้วยน้ำส้มสายชูมินท์ดังส่วนประกอบออกฤทธิ์ | |
PL413953A1 (pl) | Sposób wytwarzania czystego optycznie (+)-(R)-7-hydroksyflawanonu | |
PL404783A1 (pl) | Sposób enzymatycznego rozdziału racemicznej pochodnej α-etyloseryny | |
PL413950A1 (pl) | Sposób wytwarzania czystego optycznie (+)-(R)-7-hydroksyflawanonu |