ES2570982T3 - Un proceso para la preparación de cristales de xantofila - Google Patents

Un proceso para la preparación de cristales de xantofila

Info

Publication number
ES2570982T3
ES2570982T3 ES02783513T ES02783513T ES2570982T3 ES 2570982 T3 ES2570982 T3 ES 2570982T3 ES 02783513 T ES02783513 T ES 02783513T ES 02783513 T ES02783513 T ES 02783513T ES 2570982 T3 ES2570982 T3 ES 2570982T3
Authority
ES
Spain
Prior art keywords
lutein
extract
xanthophyll
resulting
xanthophylls
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02783513T
Other languages
English (en)
Inventor
Krishna Das Sunil Thattaruparambil
Padintaravattom Abdul Sherena
Sebastin Sajoy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OmniActive Health Technologies Ltd
Original Assignee
OmniActive Health Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31972128&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2570982(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by OmniActive Health Technologies Ltd filed Critical OmniActive Health Technologies Ltd
Application granted granted Critical
Publication of ES2570982T3 publication Critical patent/ES2570982T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un proceso para la preparación de cristales de xantofila que contienen al menos 85% de xantofilas totales con al menos 90% de trans-luteína y/o zeaxantina, cantidades muy pequeñas de cis-luteína y otros carotenoides, que comprende (a) saponificar ésteres de xantofila presentes en un extracto/oleorresina de un material vegetal adecuado mezclando el extracto/oleorresina con una disolución alcohólica de álcali sin adición de agua y calentando la disolución resultante a una temperatura en el intervalo de 65 a 80 °C; (b) separar el alcohol de la mezcla resultante bajo presión reducida para obtener un concentrado crudo saponificado; (c) mezclar el concentrado crudo saponificado resultante, obtenido en la operación (b), con agua para formar una mezcla oleosa diluida; y (d) someter la mezcla oleosa diluida, obtenida en la operación (c), a extracción con acetato de etilo para obtener un extracto que contiene xantofilas y recuperar cristales de xantofila que contienen al menos 85% de xantofilas totales con al menos 90% de trans-luteína y/o zeaxantina, cantidades muy pequeñas de cis-luteína y otros carotenoides mediante métodos convencionales.
ES02783513T 2002-08-26 2002-11-13 Un proceso para la preparación de cristales de xantofila Expired - Lifetime ES2570982T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN622MA2002 2002-08-26
PCT/IN2002/000219 WO2004018417A1 (en) 2002-08-26 2002-11-13 An improved process for the preparation of xanthophyll crystals

Publications (1)

Publication Number Publication Date
ES2570982T3 true ES2570982T3 (es) 2016-05-23

Family

ID=31972128

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02783513T Expired - Lifetime ES2570982T3 (es) 2002-08-26 2002-11-13 Un proceso para la preparación de cristales de xantofila

Country Status (8)

Country Link
US (1) US6743953B2 (es)
EP (2) EP1534673B1 (es)
JP (1) JP4252535B2 (es)
AU (1) AU2002347590B2 (es)
CA (1) CA2496495C (es)
DK (1) DK1534673T3 (es)
ES (1) ES2570982T3 (es)
WO (1) WO2004018417A1 (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5382714A (en) * 1994-03-17 1995-01-17 The Catholic University Of America Process for isolation, purification, and recrystallization of lutein from saponified marigold oleoresin and uses thereof
US7691406B2 (en) * 2000-10-27 2010-04-06 ZeaVision LLC. Zeaxanthin formulations for human ingestion
ATE382340T1 (de) * 2002-01-30 2008-01-15 Dsm Ip Assets Bv Lutein/zeaxanthin gegen blendung
PE20050398A1 (es) * 2003-09-22 2005-06-03 Rosales Jose Antonio Socla Proceso y purificacion de las xantofilas de marigold
KR20040074642A (ko) * 2004-07-12 2004-08-25 (주)에취제이시 Purified lutein의 제조공정에서 건조조건
US7351424B2 (en) * 2004-07-22 2008-04-01 Bio Lut S.A. De C.V. Enhanced purity trans-lutein-ester compositions and methods of making same
GB0501365D0 (en) * 2005-01-21 2005-03-02 Promar As Compositions
US8481769B2 (en) * 2005-04-25 2013-07-09 Katra Phytochem (India) Private Limited Isolation and purification of cartenoids from marigold flowers
PL1877371T3 (pl) * 2005-04-25 2011-07-29 Katra Phytochem India Private Ltd Izolacja i oczyszczanie karotenoidów z nagietków
CN1332947C (zh) * 2005-08-03 2007-08-22 浙江医药股份有限公司新昌制药厂 一种从植物油树脂中分离提纯叶黄素晶体的方法
CN1793123B (zh) * 2005-12-27 2010-10-27 成都枫澜科技有限公司 一种由万寿菊干花制备叶黄素晶体的方法
ES2281276B1 (es) * 2005-12-29 2008-06-16 Investigaciones Quimicas Y Farmaceuticas, S.A. Procedimiento para la preparacion de concentrados de xantofilas.
ES2281277B1 (es) * 2005-12-29 2008-06-16 Investigaciones Quimicas Y Farmaceuticas, S.A. Procedimiento para la preparacion de xantofilas de origen natural de elevada pureza.
AT503329A1 (de) * 2006-03-02 2007-09-15 Omnica Gmbh Verfahren zur herstellung einer zusammensetzung, welche zumindest ein xantophyll enthält
JP4615470B2 (ja) * 2006-03-29 2011-01-19 卓郎 簑和田 大脳の認知力を用いた疾患治療・予防の方法および医薬
US8212063B2 (en) * 2006-05-10 2012-07-03 Omniactive Health Technologies Limited Xanthophyll composition containing trans, meso-zeaxanthin, trans, R, R-zeaxanthin and trans, R, R-lutein useful for nutrition and health care and a process for its preparation
ES2318992B1 (es) * 2006-09-18 2009-12-28 Carotenoid Technologies, S.A. Procedimiento para la preparacion de luteina esencialmente pura a partir de extractos de marigold.
US8034983B2 (en) 2007-06-06 2011-10-11 Multi-Tech Specialty Chemicals, Co., Ltd. Process for the preparation of xanthophyll crystals
WO2009019712A1 (en) * 2007-08-03 2009-02-12 Omniactive Health Technologies Pvt Ltd. Novel xanthophyll composition contaning (trans, meso) - zeaxanthin, and a process for its preparation
CN101402597A (zh) * 2008-10-31 2009-04-08 南京泛成生物化工有限公司 叶黄素提取工艺
EP2196207B1 (en) 2008-12-12 2012-09-05 Allied Biotech Corporation Method for the purification of carotenoids from plant extracts and the products so obtained
US8344255B2 (en) * 2009-01-16 2013-01-01 Adc Telecommunications, Inc. Cable with jacket including a spacer
WO2010094986A1 (en) * 2009-02-18 2010-08-26 Innova Andina S.A Micronized carotenoid preparation as immunostimulant for crustaceans
AU2010200636B2 (en) * 2009-04-27 2015-05-28 Katra Phytochem (India) Private Limited A process for isolation of carotenoids from plant sources
US8247615B2 (en) 2010-05-14 2012-08-21 Kalamazoo Holdings, Inc. Process of converting esterified xanthophylls from Capsicum to non-esterified xanthophylls in high yields and purities
US8716533B2 (en) 2009-05-29 2014-05-06 Kalamazoo Holdings, Inc. Methods of saponifying xanthophyll esters and isolating xanthophylls
PT2473065E (pt) * 2009-09-02 2016-06-03 Omniactive Health Tech Ltd Uma composição de xantofila contendo pigmentos maculares e um processo para a sua preparação
US9109120B2 (en) 2010-05-17 2015-08-18 Dynadis Biotech India Private Limited Process for isolation and purification of carotenoids
UA111979C2 (uk) * 2011-08-26 2016-07-11 Птт Глобал Кемікал Паблік Компані Лімітед Спосіб екстракції лютеїну з природних матеріалів
CN103402956B (zh) 2011-12-31 2015-06-17 晨光生物科技集团股份有限公司 一种制备叶黄素晶体的方法
CN102887848A (zh) * 2012-10-30 2013-01-23 长沙芬康生物科技有限公司 一种催化皂化万寿菊油膏制备叶黄素晶体的方法
CN102964284B (zh) * 2012-11-16 2014-06-18 广州立达尔生物科技股份有限公司 一种高纯度叶黄素晶体的制备方法
PE20151085A1 (es) 2012-12-19 2015-07-25 Novus Int Inc Composicion de xantofilas
CN103936643B (zh) * 2014-03-20 2016-07-06 江苏大学 一种提取分离万寿菊中叶黄素和黄酮的方法
SG11201607996SA (en) 2014-03-28 2016-11-29 Omniactive Health Technologies Ltd Effect of lipophilic nutrients on diabetic eye diseases
CN109232345B (zh) 2018-07-10 2021-03-09 浙江医药股份有限公司新昌制药厂 一种从含叶黄素二酯的植物油树脂中提取分离叶黄素晶体的方法
CA3114066A1 (en) * 2018-09-26 2020-04-02 Omniactive Health Technologies Limited Purified xanthophyll composition comprising (trans,r,r)- lutein and(trans,r,r)- zeaxanthin and process for the preparation thereof
CN109134254B (zh) * 2018-09-28 2021-06-01 晨光生物科技集团股份有限公司 一种制备高纯度叶黄素酯的工业化方法
CN110663953A (zh) * 2019-10-29 2020-01-10 内江金瑞莫生物科技有限公司 一种极性分散叶黄素、利用叶黄素得到虾青素的制备工艺

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES272387A1 (es) 1961-08-01 1962-03-16 Lackey George Dewey Jr Procedimiento para la obtención de agentes de pigmentación para aves y sus productos
US3523138A (en) * 1965-03-01 1970-08-04 Eastman Kodak Co Treatment of marigold petal meal to obtain a xanthophyll product
US3539686A (en) 1967-04-10 1970-11-10 Ralph Rosenberg Pigmentation in poultry husbandry
US4048203A (en) 1976-12-06 1977-09-13 Thomas Philip Purification of lutein-fatty acid esters from plant materials
US5382714A (en) 1994-03-17 1995-01-17 The Catholic University Of America Process for isolation, purification, and recrystallization of lutein from saponified marigold oleoresin and uses thereof
US5602286A (en) * 1995-06-07 1997-02-11 Cargill, Incorporated Process for recovering xanthophylls from corn gluten
US5648564A (en) 1995-12-21 1997-07-15 Kemin Industries, Inc. Process for the formation, isolation and purification of comestible xanthophyll crystals from plants
WO1998045241A2 (en) 1997-04-04 1998-10-15 Henkel Corporation Lutein esters having high bioavailability
US6221417B1 (en) 1997-05-14 2001-04-24 Kemin Industries, Inc. Conversion of xanthophylls in plant material for use as a food colorant
US5876782A (en) * 1997-05-14 1999-03-02 Kemin Industries, Inc. Method for the conversion of xanthophylls in plant material
US5973211A (en) * 1997-07-18 1999-10-26 Prodemex, S.A. De C.V. Pigmenting efficiency of a natural xanthophyll by isomerization
WO1999020587A1 (en) 1997-10-21 1999-04-29 Office Of Technology Liaison Process for extraction and purification of lutein, zeaxanthin and rare carotenoids from marigold flowers and plants
IN189750B (es) * 1997-10-31 2003-04-19 Bioquimex Reka S A De C V
US6191293B1 (en) 1998-04-20 2001-02-20 Inexa, Industria Extractora C.A. Trans-xanthophyll ester concentrates of enhanced purity and methods of making same
US6262284B1 (en) 1998-10-21 2001-07-17 University Of Maryland Process for extraction and purification of lutein, zeaxanthin and rare carotenoids from marigold flowers and plants
US6504067B1 (en) * 1999-11-24 2003-01-07 Industrial Organica S.A. De C.V. Process to obtain xanthophyll concentrates of high purity
US6329557B1 (en) 2000-06-09 2001-12-11 Prodemex, S.A. De C.V. Purification of xanthophylls from marigold extracts that contain high levels of chlorophylls
US6380442B1 (en) 2001-10-10 2002-04-30 Bioactives, Llc Process for the isolation of mixed carotenoids from plants
JP2003201497A (ja) 2002-01-08 2003-07-18 Riken Vitamin Co Ltd ルテイン脂肪酸エステル濃縮物の製造方法

Also Published As

Publication number Publication date
AU2002347590B8 (en) 2004-03-11
DK1534673T3 (en) 2016-06-27
US6743953B2 (en) 2004-06-01
JP4252535B2 (ja) 2009-04-08
EP2292598B1 (en) 2017-06-28
CA2496495A1 (en) 2004-03-04
JP2005536547A (ja) 2005-12-02
AU2002347590A1 (en) 2004-03-11
WO2004018417A1 (en) 2004-03-04
AU2002347590B2 (en) 2008-01-03
EP1534673A1 (en) 2005-06-01
EP1534673B1 (en) 2016-03-30
CA2496495C (en) 2008-08-26
EP2292598A2 (en) 2011-03-09
US20040044085A1 (en) 2004-03-04
EP2292598A3 (en) 2012-04-25

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